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Browsing by Subject "animal experiment"

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    • Article  

      Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells 

      Antoniades, Ioanna; Stylianou, Panayiota; Christodoulou, Neophytos; Skourides, Paris A. (2017)
      We previously identified focal adhesion kinase (FAK) as an important regulator of ciliogenesis in multiciliated cells. FAK and other focal adhesion (FA) proteins associate with the basal bodies and their striated rootlets ...

    • Article  

      Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels 

      Chauhan, V. P.; Martin, J. D.; Liu, H.; Lacorre, D. A.; Jain, S. R.; Kozin, S. V.; Stylianopoulos, T.; Mousa, A. S.; Han, X.; Adstamongkonkul, P.; Popovic, Z.; Huang, P.; Bawendi, M. G.; Boucher, Y.; Jain, R. K. (2013)
      Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...

    • Article  

      Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer 

      Punj, V.; Bhattacharyya, S.; Saint-Dic, D.; Vasu, C.; Cunningham, E. A.; Graves, J.; Yamada, T.; Constantinou, Andreas I.; Christov, K.; White, B.; Li, G.; Majumdar, D.; Chakrabarty, A. M.; Das Gupta, T. K. (2004)
      Azurin, a copper-containing redox protein released by the pathogenic bacterium Pseudomonas aeruginosa, is highly cytotoxic to the human breast cancer cell line MCF-7, but is less cytotoxic toward p53-negative (MDA-MB-157) ...

    • Article  

      Beneficial effects of a vanadium complex with cysteine, administered at low doses on benzo(α) pyrene-induced leiomyosarcomas in wistar rats 

      Liasko, Roman; Kabanos, Themistoklis A.; Karkabounas, Spyridon Ch; Malamas, Michael Ph; Tasiopoulos, Anastasios J.; Stefanou, Dimitrios G.; Collery, P.; Evangelou, Angelos M. (1998)
      Background: Vanadium is a potent environmental and body metal, possessing remarkable antitumor and antidiabetic properties. Vanadium salts and complexes have been widely investigated for their anticarcinogenic properties ...

    • Article  

      Calpain2 protease: A new member of the Wnt/Ca2+ pathway modulating convergent extension movements in Xenopus 

      Zanardelli, Sara; Christodoulou, Neophytos; Skourides, Paris A. (2013)
      Calpains are a family of calcium-dependent intracellular cysteine proteases that regulate several physiological processes by limited cleavage of different substrates. The role of Calpain2 in embryogenesis is not clear with ...

    • Article  

      Character displacement of song and morphology in African tinkerbirds 

      Kirschel, A. N. G.; Blumstein, Daniel T.; Smith, T. B. (2009)
      Divergence in acoustic signals between populations of animals can lead to species recognition failure, reproductive isolation, and speciation. Character displacement may facilitate coexistence of species in natural ...

    • Article  

      Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats 

      Constantinou, Andreas I.; Lantvit, D.; Hawthorne, M.; Xu, X.; Van Breemen, R. B.; Pezzuto, J. M. (2001)
      There are conflicting reports on the effect of soy and its components on mammary carcinogenesis in adult female rats, mainly because of different rodent models that are used in chemoprevention studies. The present study ...

    • Article  

      Combined chemical and optical methods for monitoring the early decay stages of surrogate human models 

      Statheropoulos, Miltiades K.; Agapiou, Agapios; Zorba, Eleni; Mikedi, Katerina; Karma, Sofia; Pallis, George C.; Eliopoulos, C.; Spiliopoulou, C. (2011)
      As the body decays shortly after death, a variety of gases and volatile organic compounds (VOCs) constantly emanate. Ethical and practical reasons limit the use of human corpses in controlled, time-dependent, intervening ...

    • Article  

      Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways 

      Koupepidou, P.; Felekkis, Kyriacos N.; Kränzlin, B.; Sticht, C.; Gretz, N.; Constantinou-Deltas, Constantinos D. (2010)
      Background: Polycystic Kidney Disease is characterized by the formation of large fluid-filled cysts that eventually destroy the renal parenchyma leading to end-stage renal failure. Although remarkable progress has been ...

    • Article  

      Deficiencies in the Fanconi Anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer 

      Park, J. W.; Pitot, H. C.; Strati, K.; Spardy, N.; Duensing, S.; Grompe, M.; Lambert, P. F. (2010)
      Patients with the rare genetic disease, Fanconi anemia (FA), are highly susceptible to squamous cell carcinomas arising at multiple anatomic sites including the head and neck region. Human papillomaviruses (HPVs), particularly ...

    • Article  

      Dietary retinoids and carotenoids in rodent models of mammary tumorigenesis 

      Moon, R. C.; Constantinou, Andreas I. (1997)
      In this review of the scientific literature the relationship between retinoids, carotenoids, and mammary carcinogenesis is examined. Several retinoids have shown promise as chemopreventive agents against chemically induced ...

    • Article  

      Dietary Soy Isoflavones and Estrone Protect Ovariectomized ERαKO and Wild-Type Mice from Carcinogen-Induced Colon Cancer 

      Guo, J. -Y; Li, X.; Browning Jr., J. D.; Rottinghaus, G. E.; Lubahn, D. B.; Constantinou, Andreas I.; Bennink, M.; MacDonald, R. S. (2004)
      Consumption of soy foods has been weakly associated with reduced colon cancer risk. Colon cancer risk is influenced by estrogen exposure, although the mechanism through which this occurs is not defined. Conversion of ...

    • Article  

      Distribution of epidermal growth factor receptors in normal and neoplastic mammary tissues 

      Mehta, R. G.; Mehta, R. R.; Constantinou, Andreas I.; Moon, R. C. (1995)
      Epidermal growth factor (EGF) is considered to be mitogenic for proliferation of mammary glands in animals. The action of EGF is mediated by specific EGF receptors (EGF-R). In the present study, we investigated distribution ...

    • Article  

      Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection 

      Apidianakis, Yiorgos; Que, Y. -A; Xu, W.; Tegos, G. P.; Zimniak, P.; Hamblin, M. R.; Tompkins, R. G.; Xiao, W.; Rahme, L. G. (2012)
      Patients with severe burns are highly susceptible to bacterial infection. While immunosuppression facilitates infection, the contribution of soft tissues to infection beyond providing a portal for bacterial entry remains ...

    • Article  

      Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques 

      Jin, X.; Bauer, D. E.; Tuttleton, S. E.; Lewin, S.; Gettie, A.; Blanchard, J.; Irwin, C. E.; Safrit, J. T.; Mittler, J.; Weinberger, L.; Kostrikis, Leontios G.; Zhang, L.; Perelson, A. S.; Ho, David D. (1999)
      To determine the role of CD8+ T cells in controlling simian immunodeficiency virus (SIV) replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 monoclonal antibody, OKT8F. There was ...

    • Article  

      Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection 

      Apidianakis, Yiorgos; Rahme, L. G. (2009)
      Conservation of host signaling pathways and tissue physiology between Drosophila melanogaster and mammals allows for the modeling of human host-pathogen interactions in Drosophila. Here we present the use of genetically ...

    • Article  

      The effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D/PKCα 

      Tonetti, D. A.; Zhang, Y.; Zhao, H.; Lim, S. -B; Constantinou, Andreas I. (2007)
      Soy supplements are often consumed by women for alleviating menopausal symptoms or for the perceived protective effects against breast cancer. More concerning is the concurrent consumption of soy isoflavones with tamoxifen ...

    • Article  

      Effects of in Vivo CD8+ T cell depletion on virus replication in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine 

      Metzner, K. J.; Jin, X.; Lee, F. V.; Gettie, A.; Bauer, D. E.; Di Mascio, M.; Perelson, A. S.; Marx, P. A.; Ho, David D.; Kostrikis, Leontios G.; Connor, R. I. (2000)
      The role of CD8+ T lymphocytes in controlling replication of live, attenuated simian immunodeficiency virus (SIV) was investigated as part of a vaccine study to examine the correlates of protection in the SIV/rhesus macaque ...

    • Article  

      Effects of sol-gel synthesis on 5Fe-15Mn-40Zn-40Ti-O mixed oxide structure and its H2S removal efficiency from industrial gas streams 

      Polychronopoulou, Kyriaki; Efstathiou, Angelos M. (2009)
      A novel Fe-Mn-Zn-Ti-O mixed metal oxide has been developed for efficient low-temperature (25-50°C) removal of H2S from a gas mixture containing 600 ppm H2S, 25 vol% H2, 7.5 vol % CO 2, and 1-3 vol% H2O that simulates typical ...

    • Article  

      FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases 

      Mojsilovic-Petrovic, J.; Nedelsky, N.; Boccitto, M.; Mano, I.; Georgiades, Savvas N.; Zhou, W.; Liu, Y.; Neve, R. L.; Taylor, J. P.; Driscoll, M.; Clardy, J.; Merry, D.; Kalb, R. G. (2009)
      Aging is a risk factor for the development of adult-onset neurodegenerative diseases. Although some of the molecular pathways regulating longevity and stress resistance in lower organisms are defined (i.e., those activating ...

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