Browsing by Subject "antidiabetic agent"

Now showing items 1-4 of 4

Article

The 1.76 Å resolution crystal structure of glycogen phosphorylase b complexed with glucose, and CP320626, a potential antidiabetic drug

Oikonomakos, Nikos G.; Zographos, Spyros E.; Skamnaki, Vicky T.; Archontis, Georgios Z. (2002)

CP320626, a potential antidiabetic drug, inhibits glycogen phosphorylase in synergism with glucose. To elucidate the structural basis of synergistic inhibition, we determined the structure of muscle glycogen phosphorylase ...
Article

Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes

Georgiades, Savvas N.; Mak, L. H.; Angurell, I.; Rosivatz, E.; Firouz Mohd Mustapa, M.; Polychroni, Christoulla; Woscholski, R.; Vilar, R. (2011)

The discovery of small-molecule modulators of signaling pathways is currently a particularly active area of research. We aimed at developing unprecedented metal-based activators of Akt signaling which can potentially find ...
Article

Synthesis, structure, and biological activity of a new insulinomimetic peroxovanadium compound: Bisperoxovanadium imidazole monoanion [3]

Crans, D. C.; Keramidas, Anastasios D.; Hoover-Litty, H.; Anderson, O. P.; Miller, M. M.; Lemoine, L. M.; Pleasic-Williams, S.; Vandenberg, M.; Rossomando, A. J.; Sweet, L. J. (1997)
Article

Vanadium chemistry and biochemistry of relevance for use of vanadium compounds as antidiabetic agents

Crans, D. C.; Mahroof-Tahir, M.; Keramidas, Anastasios D. (1995)

The stability of 11 vanadium compounds is tested under physiological conditions and in administration fluids. Several compounds including those currently used as insulin-mimetic agents in animal and human studies are stable ...

Browsing by Subject "antidiabetic agent"

The 1.76 Å resolution crystal structure of glycogen phosphorylase b complexed with glucose, and CP320626, a potential antidiabetic drug ﻿

Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes ﻿

Synthesis, structure, and biological activity of a new insulinomimetic peroxovanadium compound: Bisperoxovanadium imidazole monoanion [3] ﻿

Vanadium chemistry and biochemistry of relevance for use of vanadium compounds as antidiabetic agents ﻿

The 1.76 Å resolution crystal structure of glycogen phosphorylase b complexed with glucose, and CP320626, a potential antidiabetic drug

Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes

Synthesis, structure, and biological activity of a new insulinomimetic peroxovanadium compound: Bisperoxovanadium imidazole monoanion [3]

Vanadium chemistry and biochemistry of relevance for use of vanadium compounds as antidiabetic agents