Browsing by Subject "biological model"

Article

Assessment of the risk factors of coronary heart events based on data mining with decision trees

Karaolis, Minas A.; Moutiris, Joseph Antoniou; Hadjipanayi, Demetra; Pattichis, Constantinos S. (2010)

Coronary heart disease (CHD) is one of the major causes of disability in adults as well as one of the main causes of death in the developed countries. Although significant progress has been made in the diagnosis and treatment ...

Article

Balanced translocations for the analysis of imprinted regions of the mouse genome.

Ferguson-Smith, A. C.; Tevendale, M.; Georgiades, Pantelis; Grandjean, V. (2001)

Experimental studies that investigate the functional and mechanistic properties of an imprinted locus require material in which the two parental chromosome homologs can be easily distinguished. The use of animals with ...

Article

Biphasic modeling of brain tumor biomechanics and response to radiation treatment

Angeli, S.; Stylianopoulos, T. (2016)

Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical ...

Article

Classification capacity of a modular neural network implementing neurally inspired architecture and training rules

Poirazi, Panayiota; Neocleous, Costas K.; Pattichis, Constantinos S.; Schizas, Christos N. (2004)

A three-layer neural network (NN) with novel adaptive architecture has been developed. The hidden layer of the network consists of slabs of single neuron models, where neurons within a slab-but not between slabs- have the ...

Article

Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis

Van Heemst, J.; Jansen, D. T. S. L.; Polydorides, Savvas; Moustakas, Antonis K.; Bax, M.; Feitsma, A. L.; Bontrop-Elferink, D. G.; Baarse, M.; Van Der Woude, D.; Wolbink, G. -J; Rispens, T.; Koning, F.; De Vries, R. R. P.; Papadopoulos, George K.; Archontis, Georgios Z.; Huizinga, T. W.; Toes, R. E. (2015)

The HLA locus is the strongest risk factor for anti-citrullinated protein antibody (ACPA) + rheumatoid arthritis (RA). Despite considerable efforts in the last 35 years, this association is poorly understood. Here we ...

Article

Distinguishing the causes of firing with themembrane potential slope

Koutsou, Achilleas; Christodoulou, Chris C.; Bugmann, G.; Kanev, J. (2012)

In this letter, we aim to measure the relative contribution of coincidence detection and temporal integration to the firing of spikes of a simple neuron model. To this end, we develop a method to infer the degree of synchrony ...

Article

Drosophila and the hallmarks of cancer

Christofi, T.; Apidianakis, Yiorgos (2013)

: Cancer was the disease of the twentieth century. Today it is still a leading cause of death worldwide despite being intensively investigated. Abundant knowledge exists regarding the pathological and molecular mechanisms ...

Article

Editorial

Lucas, P.; Rospars, J. -P; Christodoulou, Chris C. (2015)

Article

The Effect of Head Rotation on the Geometry and Hemodynamics of Healthy Vertebral Arteries

Aristokleous, Nicolas; Seimenis, Ioannis; Georgiou, Georgios C.; Nicolaïdes, Andrew N.; Anayiotos, Andreas S. (2015)

The geometric and hemodynamic characteristics of the left and right vertebral arteries (LVA, RVA) of six healthy volunteers were investigated for the supine (S) and the prone position (P) a common sleeping posture with ...

Article

Effect of posture change on the geometric features of the healthy carotid bifurcation

Aristokleous, Nicolas; Seimenis, Ioannis; Papaharilaou, Yannis; Georgiou, Georgios C.; Brott, B. C.; Eracleous, Eleni A.; Anayiotos, Andreas S. (2011)

Segmented cross-sectional MRI images were used to construct 3-D virtual models of the carotid bifurcation in ten healthy volunteers. Geometric features, such as bifurcation angle, internal carotid artery (ICA) angle, ...

Article

Evolution of osmotic pressure in solid tumors

Voutouri, C.; Stylianopoulos, T. (2014)

The mechanical microenvironment of solid tumors includes both fluid and solid stresses. These stresses play a crucial role in cancer progression and treatment and have been analyzed rigorously both mathematically and ...

Article

Hemodynamics in stenotic vessels of small diameter under steady state conditions: Effect of viscoelasticity and migration of red blood cells

Dimakopoulos, Yannis; Kelesidis, G.; Tsouka, S.; Georgiou, Georgios C.; Tsamopoulos, J. (2015)

BACKGROUND: In microcirculation, the non-Newtonian behavior of blood and the complexity of the microvessel network are responsible for the high flow resistance and the large reduction of the blood pressure. Red blood cell ...

Article

Impact of head rotation on the individualized common carotid flow and carotid bifurcation hemodynamics

Aristokleous, Nicolas; Seimenis, Ioannis; Georgiou, Georgios C.; Papaharilaou, Yannis; Brott, B. C.; Nicolaïdes, Andrew N.; Anayiotos, Andreas S. (2014)

This paper aims at evaluating the changes that head rotation poses on morphological and flow characteristics of the carotid bifurcation (CB) and on the distribution of parameters that are regarded as important in atherosclerosis ...

Article

A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis

Erguler, K.; Pieri, Myrtani; Constantinou-Deltas, Constantinos D. (2013)

Background: The unfolded protein response (UPR) is a major signalling cascade acting in the quality control of protein folding in the endoplasmic reticulum (ER). The cascade is known to play an accessory role in a range ...

Article

Multiagent reinforcement learning: Spiking and nonspiking agents in the Iterated Prisoner's Dilemma

Vassiliades, Vassilis; Cleanthous, A.; Christodoulou, Chris C. (2011)

This paper investigates multiagent reinforcement learning (MARL) in a general-sum game where the payoffs' structure is such that the agents are required to exploit each other in a way that benefits all agents. The contradictory ...

Article

Multiscale biphasic modelling of peritumoural collagen microstructure: The effect of tumour growth on permeability and fluid flow

Wijeratne, P. A.; Hipwell, J. H.; Hawkes, D. J.; Stylianopoulos, T.; Vavourakis, V. (2017)

We present an in-silico model of avascular poroelastic tumour growth coupled with a multiscale biphasic description of the tumour–host environment. The model is specified to in-vitro data, facilitating biophysically realistic ...

Article

Multiscale modelling of solid tumour growth: the effect of collagen micromechanics

Wijeratne, P. A.; Vavourakis, V.; Hipwell, J. H.; Voutouri, C.; Papageorgis, P.; Stylianopoulos, T.; Evans, A.; Hawkes, D. J. (2016)

Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...

Article

On learning time delays between the spikes from different input neurons in a biophysical model of a pyramidal neuron

Koutsou, Achilleas; Bugmann, G.; Christodoulou, Chris C. (2015)

Biological systems are able to recognise temporal sequences of stimuli or compute in the temporal domain. In this paper we are exploring whether a biophysical model of a pyramidal neuron can detect and learn systematic ...

Article

Particle deposition in a realistic geometry of the human conducting airways: Effects of inlet velocity profile, inhalation flowrate and electrostatic charge

Koullapis, P. G.; Kassinos, Stavros C.; Bivolarova, M. P.; Melikov, A. K. (2016)

Understanding the multitude of factors that control pulmonary deposition is important in assessing the therapeutic or toxic effects of inhaled particles. The use of increasingly sophisticated in silico models has improved ...

Article

Pathogenesis of intestinal Pseudomonas aeruginosa infection in patients with cancer

Markou, P.; Apidianakis, Yiorgos (2014)