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Browsing by Subject "cancer cell culture"

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    • Article  

      Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer 

      Punj, V.; Bhattacharyya, S.; Saint-Dic, D.; Vasu, C.; Cunningham, E. A.; Graves, J.; Yamada, T.; Constantinou, Andreas I.; Christov, K.; White, B.; Li, G.; Majumdar, D.; Chakrabarty, A. M.; Das Gupta, T. K. (2004)
      Azurin, a copper-containing redox protein released by the pathogenic bacterium Pseudomonas aeruginosa, is highly cytotoxic to the human breast cancer cell line MCF-7, but is less cytotoxic toward p53-negative (MDA-MB-157) ...

    • Article  

      Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: Bioassay-directed isolation and characterization of active principles 

      Burdette, J. E.; Chen, S. -N; Lu, Z. -Z; Xu, H.; White, B. E. P.; Fabricant, D. S.; Liu, J.; Fong, H. H. S.; Farnsworth, N. R.; Constantinou, Andreas I.; Van Breemen, R. B.; Pezzuto, J. M.; Bolton, J. L. (2002)
      The roots/rhizomes of Cimicifuga racemosa L. (Nutt.) (black cohosh) have traditionally been used to treat menopausal symptoms through an unknown mechanism of action. In an effort to determine if black cohosh had additional ...

    • Article  

      D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells 

      Neophytou, Christiana M.; Constantinou, Constantina; Papageorgis, P.; Constantinou, Andreas I. (2014)
      d-alpha-tocopheryl polyethylene glycol succinate (TPGS) is a vitamin E derivative that has been intensively applied as a vehicle for drug delivery systems to enhance drug solubility and increase the oral bioavailability ...

    • Article  

      Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms 

      Liu, J.; Burdette, J. E.; Xu, H.; Gu, C.; Van Breemen, R. B.; Bhat, K. P. L.; Booth, N.; Constantinou, Andreas I.; Pezzuto, J. M.; Fong, H. H. S.; Farnsworth, N. R.; Bolton, J. L. (2001)
      Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus ...

    • Article  

      Genistein as an Inducer of Tumor Cell Differentiation: Possible Mechanisms of Action 

      Constantinou, Andreas I.; Huberman, E. (1995)
      Decreased activity of either topoisomerases or tyrosine kinases has been implicated in the differentiation of a number of cell types. It is therefore conceivable that genistein, because of its reported ability to inhibit ...

    • Article  

      Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice 

      Constantinou, Andreas I.; Krygier, A. E.; Mehta, R. R. (1998)
      Results of recent studies in animal models of mammary carcinogenesis showed that the soybean isoflavone genistein is a chemopreventive agent. The objective of the present study was to determine whether soybean isoflavones ...

    • Article  

      Induction of DNA damage and caspase-independent programmed cell death by vitamin e 

      Constantinou, Constantina; Neophytou, Christiana M.; Vraka, Panayiota S.; Hyatt, John Anthony; Papas, Konstantinos A.; Constantinou, Andreas I. (2012)
      Vitamin E comprises 8 functionally unique isoforms and may be a suitable candidate for the adjuvant treatment of prostate cancer. In this study, we examined the ability of 2 vitamin E isoforms [α-tocotrienol (γ-TT) and ...

    • Article  

      Insulin-mimetic action of vanadium compounds on osteoblast-like cells in culture 

      Etcheverry, S. B.; Crans, D. C.; Keramidas, Anastasios D.; Cortizo, A. M. (1997)
      Vanadium compounds mimic insulin actions in different cell types. The present study concerns the insulin-like effects of three vanadium(V) derivatives and one vanadium(IV) complex on osteoblast-like (UMR106 and MC3T3E1) ...

    • Article  

      A novel use for the comet assay: Detection of topoisomerase II inhibitors 

      Salti, G. I.; Das Gupta, T. K.; Constantinou, Andreas I. (2000)
      Background: The simple and quick comet assay can quantitatively detect DNA cleavage in cells. This study aimed to determine whether the comet assay could be used to detect topoisomerase (topo) II inhibitors. Materials and ...

    • Article  

      Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer 

      Strati, Katerina; Lambert, P. F. (2007)
      Infection with high-risk human papillomaviruses (HPV) and in particular the expression of the viral proteins E6 and E7 have been associated with the etiology of a subset of head and neck squamous cell cancer (HNSCC). ...

    • Article  

      Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27 

      Kirmizis, Antonis; Bartley, S. M.; Kuzmichev, A.; Margueron, R.; Reinberg, D.; Green, R.; Farnham, P. J. (2004)
      Polycomb group (PcG) complexes 2 and 3 are involved in transcriptional silencing. These complexes contain a histone lysine methyltransferase (HKMT) activity that targets different lysine residues on histones H1 or H3 in ...

    • Article  

      Synthesis and study of the cancer cell growth inhibitory properties of α-, γ-tocopheryl and γ-tocotrienyl 2-phenylselenyl succinates 

      Vraka, Panayiota S.; Drouza, Chryssoula; Rikkou, Maria P.; Odysseos, Andreani D.; Keramidas, Anastasios D. (2006)
      Vitamin E succinate selenium-conjugated molecules were synthesized and their apoptogenic properties were evaluated. 4-Methyl-2-phenylselenyl succinate (4) was prepared by the reaction of sodium benzeneselenolate with ...

    • Article  

      Synthesis, characterization, and evaluation as transfection reagents of ampholytic star copolymers: Effect of star architecture 

      Georgiou, Theoni K.; Phylactou, Leonidas A.; Patrickios, Costas S. (2006)
      Five star polymers based on the positively ionizable hydrophilic 2-(dimethylamino)ethyl methacrylate (DMAEMA) and the hydrophobic but hydrolyzable tetrahydropyranyl methacrylate (THPMA) were prepared by group-transfer ...

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