Browsing by Subject "cell differentiation"

Article

Commitment to erythroid differentiation in mouse erythroleukemia cells is controlled by alterations in topoisomerase IIα phosphorylation

Constantinou, Andreas I.; Vaughan, A. T. M.; Yamasaki, H.; Kamath, N. (1996)

To explore the program of cell differentiation in Friend murine erythroleukemia (MEL) cells, we used three clonal variants: phorbol 12- myristate 13-acetate (PMA)-hypersensitive TS-19-101, PMA-resistant TR19-9, and ...

Article

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

Kuzmichev, A.; Margueron, R.; Vaquero, A.; Preissner, T. S.; Scher, M.; Kirmizis, Antonis; Ouyang, X.; Brockdorff, N.; Abate-Shen, C.; Farnham, P.; Reinberg, D. (2005)

Changes in the substrate specificities of factors that irreversibly modify the histone components of chromatin are expected to have a profound effect on gene expression through epigenetics. Ezh2 is a histone-lysine ...

Article

CXCR4 mediates entry and productive infection of syncytia-inducing (x4) hiv-1 strains in primary macrophages

Valentin, A.; Trivedi, H.; Lu, W.; Kostrikis, Leontios G.; Pavlakis, G. N. (2000)

CCR5 and CXCR4 are the main coreceptors for non-syncytia-inducing (NSI) and syncytia-inducing (SI) HIV-1 strains, respectively. NSI HIV-1 isolates do not infect either human lymphoid or monocytoid cell lines, and this ...

Article

Developmental biology: Our fly cousins' gut

Pitsouli, Chrysoula; Perrimon, N. (2008)

What do we humans have in common with flies? Quite a lot, at least at the cellular and molecular levels. Our intestine, for instance, is similar to that of the fly, not only in function but also in its development and ...

Article

Differential expression of the rat retinoid X receptor γ gene during skeletal muscle differentiation suggests a role in myogenesis

Georgiades, Pantelis; Brickell, P. M. (1997)

Even though previous studies have shown that transcripts encoding the murine retinoid X receptor γ (RXRγ) are present in skeletal muscle of mouse embryos and that cultured myoblasts are induced to differentiate upon retinoid ...

Article

Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes

Iacovides, D.; Rizki, G.; Lapathitis, Georgios; Strati, Katerina (2016)

The insufficient ability of specialized cells such as neurons, cardiac myocytes, and epidermal cells to regenerate after tissue damage poses a great challenge to treat devastating injuries and ailments. Recent studies ...

Article

Drosophila melanogaster as a model for human intestinal infection and pathology

Apidianakis, Yiorgos; Rahme, L. G. (2011)

Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this model is well suited for the study of intestinal stem cell physiology during aging, stress and infection. Despite the physiological ...

Article

The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells

Constantinou, Andreas I.; Grdina, D.; Kiguchi, K.; Huberman, E. (1992)

Treatment of human K-562-J leukemia cells for 1 h with the topoisomerase II-reactive drugs VP-16, VM-26, or mAMSA resulted in a dose-dependent inhibition of proliferation and in an increase in the percentage of cells ...

Article

Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis

Pitsouli, Chrysoula; Perrimon, N. (2010)

Adult structures in holometabolous insects such as Drosophila are generated by groups of imaginal cells dedicated to the formation of different organs. Imaginal cells are specified in the embryo and remain quiescent until ...

Article

Evidence for activation of the unfolded protein response in collagen iv nephropathies

Pieri, Myrtani; Stefanou, Charalambos; Zaravinos, Apostolos; Erguler, K.; Stylianou, Konstantinos G.; Lapathitis, Georgios; Karaiskos, Christos; Savva, Isavella; Paraskeva, Revekka; Dweep, H.; Sticht, C.; Anastasiadou, Natassa; Zouvani, Ioanna; Goumenos, Dimitrios S.; Felekkis, Kyriacos N.; Saleem, M.; Voskarides, Konstantinos; Gretz, N.; Constantinou-Deltas, Constantinos D. (2014)

Thin-basement-membrane nephropathy (TBMN) and Alport syndrome (AS) are progressive collagen IV nephropathies caused by mutations in COL4A3/A4/A5 genes. These nephropathies invariably present with microscopic hematuria and ...

Article

Genistein as an Inducer of Tumor Cell Differentiation: Possible Mechanisms of Action

Constantinou, Andreas I.; Huberman, E. (1995)

Decreased activity of either topoisomerases or tyrosine kinases has been implicated in the differentiation of a number of cell types. It is therefore conceivable that genistein, because of its reported ability to inhibit ...

Article

Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice

Constantinou, Andreas I.; Krygier, A. E.; Mehta, R. R. (1998)

Results of recent studies in animal models of mammary carcinogenesis showed that the soybean isoflavone genistein is a chemopreventive agent. The objective of the present study was to determine whether soybean isoflavones ...

Article

Genistein-induced cell differentiation and protein-linked DNA strand breakage in human melanoma cells

Kiguchi, K.; Constantinou, Andreas I.; Huberman, E. (1990)

Article

The homeobox transcription factor cut coordinates patterning and growth during drosophila airway remodeling

Pitsouli, Chrysoula; Perrimon, N. (2013)

A fundamental question in developmental biology is how tissue growth and patterning are coordinately regulated to generate complex organs with characteristic shapes and sizes. We showed that in the developing primordium ...

Article

Homeostasis in Infected Epithelia: Stem Cells Take the Lead

Pitsouli, Chrysoula; Apidianakis, Yiorgos; Perrimon, N. (2009)

To maintain tissue homeostasis and avoid disease, epithelial cells damaged by pathogens need to be readily replenished, and this is mainly achieved by the activation of stem cells. In this Short Review, we discuss recent ...

Article

Induction of Differentiation and DNA Strand Breakage in Human HL-60 and K-562 Leukemia Cells by Genistein

Constantinou, Andreas I.; Kiguchi, K.; Huberman, E. (1990)

Genistein, an in vitro inhibitor of topoisomerase II and tyrosine kinases, suppressed growth and induced differentiation in HL-205 cells, a clonal population of the human promyelocytic HL-60 leukemia cells, and in K-562-J ...

Article

Induction of human adenocarcinoma cell differentiation by the phytoestrogen genistein is independent of its antiestrogenic function

Krygier, A. E.; Murley, J. S.; Mehta, R. R.; Constantinou, Andreas I. (1997)

The objective of the present study was to determine if genistein can induce human breast adenocarcinoma cell maturation. To gain understanding on its mechanism of action, we used estrogen receptor-positive (ER+) MCF-7, and ...

Article

The Ink4/Arf locus is a barrier for iPS cell reprogramming

Li, H.; Collado, M.; Villasante, A.; Strati, Katerina; Ortega, S.; Cãamero, M.; Blasco, M. A.; Serrano, M. (2009)

The mechanisms involved in the reprogramming of differentiated cells into induced pluripotent stem (iPS) cells by the three transcription factors Oct4 (also known as Pou5f1), Klf4 and Sox2 remain poorly understood. The ...

Article

Insulin-mimetic action of vanadium compounds on osteoblast-like cells in culture

Etcheverry, S. B.; Crans, D. C.; Keramidas, Anastasios D.; Cortizo, A. M. (1997)

Vanadium compounds mimic insulin actions in different cell types. The present study concerns the insulin-like effects of three vanadium(V) derivatives and one vanadium(IV) complex on osteoblast-like (UMR106 and MC3T3E1) ...

Article

KIF2β, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation

Santama, Niovi; Krijnse-Ĺocker, J.; Griffiths, G.; Noda, Y.; Hirokawa, N.; Dotti, C. G. (1998)

Lysosomes concentrate juxtanuclearly in the region around the microtubule-organizing center by interaction with microtubules. Different experimental and physiological conditions can induce these organelles to move to the ...