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Browsing by Subject "cell survival"

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    • Article  

      Biphasic modeling of brain tumor biomechanics and response to radiation treatment 

      Angeli, S.; Stylianopoulos, T. (2016)
      Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical ...

    • Article  

      Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway 

      Pavlou, Demos; Kirmizis, Antonis (2016)
      Protein N-terminal acetylation is an abundant post-translational modification in eukaryotes implicated in various fundamental cellular and biochemical processes. This modification is catalysed by evolutionarily conserved ...

    • Article  

      Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis 

      Pitsouli, Chrysoula; Perrimon, N. (2010)
      Adult structures in holometabolous insects such as Drosophila are generated by groups of imaginal cells dedicated to the formation of different organs. Imaginal cells are specified in the embryo and remain quiescent until ...

    • Article  

      Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity 

      Molina-Serrano, D.; Schiza, V.; Demosthenous, Christis; Stavrou, Emmanouil; Oppelt, J.; Kyriakou, DImitris; Liu, W.; Zisser, G.; Bergler, H.; Dang, W.; Kirmizis, Antonis (2016)
      Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary interventions with ...

    • Article  

      New antimony(III) halide complexes with dithiocarbamate ligands derived from thiuram degradation: The effect of the molecule's close contacts on in vitro cytotoxic activity 

      Urgut, O. S.; Ozturk, I. I.; Banti, Christina N.; Kourkoumelis, Nikolaos; Manoli, Maria; Tasiopoulos, Anastasios J.; Hadjikakou, Sotiris K. (2016)
      Antimony(III) halide complexes of the formulae {[SbBr(Me2DTC)2]n} (1), {[SbI(Me2DTC)2]n} (2) and {[(Me2DTC)2Sb(μ2-I)Sb(Me2DTC)2]+.I3-} (3) (Me2DTC = dimethyldithiocarbomate) were synthesized from SbX3, (X = Br or I) and ...

    • Article  

      Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo 

      Georgaki, Sylvianna; Skopeliti, Margarita; Tsiatas, Marinos L.; Nicolaou, Katerina A.; Ioannou, Kyriaki; Husband, A.; Bamias, Aristotelis T.; Dimopoulos, Meletios A.; Constantinou, Andreas I.; Tsitsilonis, Ourania E. (2009)
      Phenoxodiol (PXD) is a synthetic analogue of the plant isoflavone genistein with improved anticancer efficacy. Various properties and mechanisms of action have been attributed to the drug, the most important being its ...

    • Article  

      Structural motifs and biological studies of new antimony(iii) iodide complexes with thiones 

      Ozturk, I.; Filimonova, S.; Hadjikakou, Sotiris K.; Kourkoumelis, Nikolaos; Dokorou, Vaso N.; Manos, Manolis J.; Tasiopoulos, Anastasios J.; Barsan, M. M.; Butler, I. S.; Milaeva, E. R.; Balzarini, J.; Hadjiliadis, Nick (2010)
      Eight new antimony(III) iodide complexes of the heterocyclic thioamides, 2-mercapto-1-methylimidazole (MMI), 2-mercaptobenzlmidazole (MBZIM), 5-ethoxy-2-mercaptobenzimldazole (EtMBZIM), 2-mercaptothiazolidine (MTZD), ...

    • Article  

      Synthesis, structural characterization and in vitro inhibitory studies against human breast cancer of the bis-(2,6-di-tert-butylphenol)tin(iv) dichloride and its complexes 

      Shpakovsky, D. B.; Banti, Christina N.; Beaulieu-Houle, G.; Kourkoumelis, Nikolaos; Manoli, Maria; Manos, Manolis J.; Tasiopoulos, Anastasios J.; Hadjikakou, Sotiris K.; Milaeva, E. R.; Charalabopoulos, Konstantinos A.; Bakas, Thomas V.; Butler, I. S.; Hadjiliadis, Nick (2012)
      Four new organotin(iv) complexes of bis-(2,6-di-tert-butylphenol)tin(iv) dichloride [(tert-Bu-)2(HO-Ph)]2SnCl2 (1) with the heterocyclic thioamides 2-mercapto-pyrimidine (PMTH), 2-mercapto-4-methyl- pyrimidine (MPMTH), ...

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