Browsing by Subject "chromatin"
Now showing items 1-8 of 8
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Beyond the histone tail: acetylation at the nucleosome dyad commands transcription.
(2013)Post-translational modifications (PTMs) of histones have been implicated in cellular processes such as transcription, replication and DNA repair. These processes normally involve dynamic changes in chromatin structure and ...
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Cross-talk among epigenetic modifications: Lessons from histone arginine methylation
(2013)Epigenetic modifications, including those occurring on DNA and on histone proteins, control gene expression by establishing and maintaining different chromatin states. In recent years, it has become apparent that epigenetic ...
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Genomic approaches that aid in the identification of transcription factor target genes
(2004)It is well-established that deregulation of the transcriptional activity of many different genes has been causatively linked to human diseases. In cancer, altered patterns of gene expression are often the result of the ...
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Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy
(2003)We have previously identified SU(Z)12 as an E2F target gene. Because many E2F target genes encode proteins that are critical for the control of cell proliferation, we have further characterized the regulation and expression ...
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The Ink4/Arf locus is a barrier for iPS cell reprogramming
(2009)The mechanisms involved in the reprogramming of differentiated cells into induced pluripotent stem (iPS) cells by the three transcription factors Oct4 (also known as Pou5f1), Klf4 and Sox2 remain poorly understood. The ...
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Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity
(2016)Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary interventions with ...
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N-alpha-terminal Acetylation of Histone H4 Regulates Arginine Methylation and Ribosomal DNA Silencing
(2013)Post-translational modifications of histones play a key role in DNA-based processes, like transcription, by modulating chromatin structure. N-terminal acetylation is unique among the numerous histone modifications because ...