Browsing by Subject "deferiprone"

Article

Competition studies of L1-deferiprone with copper and iron. Possible implications on efficacy, toxicity and new therapeutic applications

Pashalidis, Ioannis; Kontoghiorghes, G. J. (2000)

Article

Effective complex formation in the interaction of 1,2-dimethyl-3-hydroxypyrid-4-one (Deferiprone or L1) with uranium(VI)

Pashalidis, Ioannis; Kontoghiorghes, G. J. (1999)

In an effort to develop new chelating agents for the decorporation of uranium and other actinides, the interaction of the clinically used 1,2-dimethyl-3-hydroxypyrid-4-one (Deferiprone or LI) with hexavalent uranium was ...

Article

Interaction between 1,2-dimethyl-3-hydroxypyrid-4-one and europium(III)

Hadjiloizou, P.; Pashalidis, Ioannis (2007)

The interaction of the clinically used 1,2-dimethyl-3-hydroxypyrid-4-one with trivalent europium Eu(III), was investigated by using potentiometric and spectroscopic methods. The stability constants of the EuLn (3-n)+ ...

Article

Interactions of hydroxycarbamide (Hydroxyurea) with Iron and copper: Implications on toxicity and therapeutic strategies

Konstantinou, E.; Pashalidis, Ioannis; Kolnagou, A.; Kontoghiorghes, G. J. (2011)

Presented at the 19th International Conference on Chelation, London, UK, 13-16 November 2009Preliminary spectrophotometric and potentiometric studies have shown that hydroxycarbamide or hydroxyurea (HU) can interact with ...

Article

Molecular factors affecting the complex formation between deferiprone (L1) and Cu(II): Possible implications on efficacy and toxicity

Pashalidis, Ioannis; Kontoghiorghes, G. J. (2001)

Deferiprone (1,2-dimethyl-3-hydroxypyrid-4-one, L1, CAS 30652-11-0) is a new chelating drug used worldwide for the treatment of iron overloading conditions. Spectrophotometric and potentiometric measurements were carried ...