Browsing by Subject "disease course"

Article

Carriers of Autosomal Recessive Alport Syndrome with Thin Basement Membrane Nephropathy Presenting as Focal Segmental Glomerulosclerosis in Later Life

Constantinou-Deltas, Constantinos D.; Savva, Isavella; Voskarides, Konstantinos; Papazachariou, Louiza; Pierides, Alkis M. (2015)

Collagen IV nephropathies (COL4Ns) comprise benign familial microscopic hematuria, thin basement membrane nephropathy (TBMN), X-linked Alport syndrome (AS) and also autosomal recessive and dominant AS. Apart from the ...

Article

Cellular HIV type 1 DNA levels are equivalent among drug-sensitive and drug-resistant strains in newly diagnosed and antiretroviral naive patients

Antoniadou, Zoi Anna; Hezka, Johana; Kousiappa, Ioanna; Mamais, Ioannis A.; Skoura, Lemonia G.; Pilalas, Dimitrios; Metallidis, Simeon A.; Nicolaidis, Pavlos; Malisiovas, Nikolaos; Kostrikis, Leontios G. (2014)

The emergence of resistance against current antiretroviral drugs to human immunodeficiency virus type 1 (HIV-1) is an increasingly important concern to the continuous success of antiretroviral therapy to HIV-1-infected ...

Article

Changes in T Cell Receptor Excision DNA Circle (TREC) Levels in HIV Type 1-Infected Subjects Pre- and Post-Highly Active Antiretroviral Therapy

Touloumi, G.; Pantazis, N.; Karafoulidou, A.; Mandalaki, T.; Goedert, J. J.; Kostrikis, Leontios G.; Hatzakis, Angelos E. (2004)

The T cell receptor excision DNA circle (TREC) level is an independent predictor of HIV-1 disease prognosis. We studied the temporal changes in TREC levels prior to and after highly active antiretroviral therapy (HAART) ...

Article

A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation

Deutsch, L.; Kostrikis, Leontios G.; Huang, Y.; Moore, J. P.; Wolinsky, S. M.; Zhang, L.; Guo, Y.; Phair, J.; Neumann, A. U.; Ho, David D. (1998)

Viral and host factors influence the rate of HIV-1 disease progression. For HIV-1 to fuse, a CD4+ cell must express a co-receptor that the virus can use. The chemokine receptors CCR5 and CXCR4 are used by R5 and X4 viruses, ...

Article

Clinico-pathological correlations in 127 patients in 11 large pedigrees, segregating one of three heterozygous mutations in the COL4A3 COL4A4 genes associated with familial haematuria and significant late progression to proteinuria and chronic kidney disease from focal segmental glomerulosclerosis

Pierides, Alkis M.; Voskarides, Konstantinos; Athanasiou, Yiannis; Ioannou, Kyriakos; Damianou, Loukas; Arsali, Maria; Zavros, Michalis; Pierides, M.; Vargemezis, V.; Patsias, Charalambos; Zouvani, Ioanna; Elia, Avraam; Kyriacou, Kyriacos C.; Constantinou-Deltas, Constantinos D. (2009)

Background. Heterozygous mutations in the COL4A3 COL4A4 genes are currently thought to be responsible for familial benign microscopic haematuria and maintenance of normal long-term kidney function.Methods. We report on 11 ...

Article

Co-Inheritance of Functional Podocin Variants with Heterozygous Collagen IV Mutations Predisposes to Renal Failure

Stefanou, Charalambos; Pieri, Myrtani; Savva, Isavella; Georgiou, Georgios C.; Pierides, Alkis M.; Voskarides, Konstantinos; Constantinou-Deltas, Constantinos D. (2015)

BACKGROUND/AIMS: A subset of patients who present with proteinuria and are diagnosed with focal segmental glomerulosclerosis (FSGS) have inherited heterozygous COL4A3/A4 mutations and are also diagnosed with thin basement ...

Article

Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways

Koupepidou, P.; Felekkis, Kyriacos N.; Kränzlin, B.; Sticht, C.; Gretz, N.; Constantinou-Deltas, Constantinos D. (2010)

Background: Polycystic Kidney Disease is characterized by the formation of large fluid-filled cysts that eventually destroy the renal parenchyma leading to end-stage renal failure. Although remarkable progress has been ...

Article

Cystic fibrosis patients from the black sea region: The 1677delTA mutation

Angelicheva, D.; Boteva, Kalina; Jordanova, A.; Savov, A.; Kufardjieva, A.; Tolun, A.; Telatar, M.; Akarsubaşi, A.; Köprübaşi, F.; Aydoǧdu, S.; Demirkol, M.; Kurdoǧlu, G.; Constantinou-Deltas, Constantinos D.; Georgiou, Christina; Dean, M.; Ivaschenko, T.; Baranov, V.; Kalaydjieva, L. (1994)

A 2 bp deletion in exon 10 of the CFTR gene, 1677delTA, which is very rare among CF chromosomes worldwide, was found to be a relatively common cause of cystic fibrosis in countries located in the region of the Black Sea. ...

Article

Effect of recent thymic emigrants on progression of HIV-1 disease

Hatzakis, Angelos E.; Touloumi, G.; Karanicolas, R.; Karafoulidou, A.; Mandalaki, T.; Anastassopoulou, C. G.; Zhang, L.; Goedert, J. J.; Ho, David D.; Kostrikis, Leontios G. (2000)

Background. The concentration of T-cell receptor-rearrangement excision DNA circles (TREC) in peripheral-blood T cells is a marker of recent thymic emigrant αβ T cells. We studied the predictive ability of measurements of ...

Article

Effects of CCR5-Δ32, CCR2-64I, and SDF-1 3′ a alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data

Ioannidis, J. P. A.; Rosenberg, P. S.; Goedert, J. J.; Ashton, L. J.; Benfield, T. L.; Buchbinder, S. P.; Coutinho, R. A.; Eugen-Olsen, J.; Gallart, T.; Katzenstein, T. L.; Kostrikis, Leontios G.; Kuipers, H.; Louie, L. G.; Mallal, S. A.; Margolick, J. B.; Martinez, O. P.; Meyer, L.; Michael, N. L.; Operskalski, E.; Pantaleo, G.; Rizzardi, G. P.; Schuitemaker, H.; Sheppard, H. W.; Stewart, G. J.; Theodorou, I. D.; Ullum, H.; Vicenzi, E.; Vlahov, D.; Wilkinson, D.; Workman, C.; Zagury, J. -F; O'Brien, T. R. (2001)

Background: Studies relating certain chemokine and chemokine receptor gene alleles with the outcome of HIV-1 infection have yielded inconsistent results. Objective: To examine postulated associations of genetic alleles ...

Article

Evidence for association of endothelial cell nitric oxide synthase gene polymorphism with earlier progression to end-stage renal disease in a cohort of Hellens from Greece and Cyprus

Lamnissou, Klea; Zirogiannis, P.; Trygonis, S.; Demetriou, Kyproula; Pierides, Alkis M.; Koptides, Michael; Constantinou-Deltas, Constantinos D. (2004)

Nitric oxide (NO) is thought to be an important factor in the deterioration of renal function. A variable-number tandem 27-bp repeat in intron 4 of the endothelial cell nitric oxide synthase (NOS3) gene has been found to ...

Article

Evidence that NPHS2-R229Q predisposes to proteinuria and renal failure in familial hematuria

Voskarides, Konstantinos; Arsali, Maria; Athanasiou, Yiannis; Elia, Avraam; Pierides, Alkis M.; Constantinou-Deltas, Constantinos D. (2012)

Background Familial hematuria (FH) is associated with at least two pathological entities: Thin basement membrane nephropathy (TBMN), caused by heterozygous COL4A3/ COL4A4 mutations, and C3 nephropathy caused by CFHR5 ...

Article

Evolution of osmotic pressure in solid tumors

Voutouri, C.; Stylianopoulos, T. (2014)

The mechanical microenvironment of solid tumors includes both fluid and solid stresses. These stresses play a crucial role in cancer progression and treatment and have been analyzed rigorously both mathematically and ...

Article

Genetic evidence for a trans-heterozygous model for cystogenesis in autosomal dominant polycystic kidney disease

Koptides, Michael; Mean, R.; Demetriou, Kyproula; Pierides, Alkis M.; Constantinou-Deltas, Constantinos D. (2000)

Polycystic kidney disease (ADPKD) is a condition with an autosomal dominant mode of inheritance and adult onset. Two forms of the disease, ADPKD1 and ADPKD2, caused by mutations in PKD1 and PKD2, respectively, are very ...

Article

HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 Δ32-negative female sex workers in Chiang Rai, northern Thailand

Sriwanthana, B.; Hodge, T.; Mastro, T. D.; Dezzutti, C. S.; Bond, K.; Stephens, H. A. F.; Kostrikis, Leontios G.; Limpakarnjanarat, K.; Young, N. L.; Qari, S. H.; Lal, R. B.; Chandanayingyong, D.; McNicholl, J. M. (2001)

Understanding how highly HIV-exposed individuals remain HIV uninfected may be useful for HIV vaccine design and development of new HIV prevention strategies. To elucidate mechanisms associated with resistance to HIV ...

Article

The impact of human allelic variation on HIV-1 disease.

Anastassopoulou, C. G.; Kostrikis, Leontios G. (2003)

Human allelic variants influence the susceptibility to HIV-1 infection and/or the subsequent rates of disease progression towards AIDS that average ten years, although they vary greatly among infected subjects. In this ...

Article

Medical diagnostic systems: A case for neural networks

Schizas, Christos N.; Pattichis, Constantinos S.; Bonsett, C. A. (1994)

Recent advances in computer technology offer to the medical profession specialized tools for gathering medical data, processing power, as well as fast storing and retrieving capabilities. Artificial intelligence (AI), an ...

Article

Meet the editorial board members

Kostrikis, Leontios G.; Koka, P. (2015)

Article

A miR-1207-5p binding site polymorphism abolishes regulation of HBEGF and is associated with disease severity in CFHR5 nephropathy

Papagregoriou, Gregory N.; Erguler, K.; Dweep, H.; Voskarides, Konstantinos; Koupepidou, P.; Athanasiou, Yiannis; Pierides, Alkis M.; Gretz, N.; Felekkis, Kyriacos N.; Constantinou-Deltas, Constantinos D. (2012)

Heparin binding epidermal growth factor (HBEGF) is expressed in podocytes and was shown to play a role in glomerular physiology. MicroRNA binding sites on the 3′UTR of HBEGF were predicted using miRWalk algorithm and ...

Article

Modeling hologenome imbalances in inflammation and cancer

Apidianakis, Yiorgos; Ferrandon, D. (2014)