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Browsing by Subject "dna topoisomerase (atp hydrolysing)"

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    • Article  

      Commitment to erythroid differentiation in mouse erythroleukemia cells is controlled by alterations in topoisomerase IIα phosphorylation 

      Constantinou, Andreas I.; Vaughan, A. T. M.; Yamasaki, H.; Kamath, N. (1996)
      To explore the program of cell differentiation in Friend murine erythroleukemia (MEL) cells, we used three clonal variants: phorbol 12- myristate 13-acetate (PMA)-hypersensitive TS-19-101, PMA-resistant TR19-9, and ...

    • Article  

      Effect of the calmodulin inhibitor trifluoperazine on phosphorylation of P-glycoprotein and topoisomerase II: Relationship to modulation of subcellular distribution, DNA damage and cytotoxicity of doxorubicin in multidrug resistant L1210 mouse leukemia cells 

      Ganapathi, R.; Kamath, N.; Constantinou, Andreas I.; Grabowski, D.; Ford, J.; Anderson, A. (1991)

    • Article  

      The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells 

      Constantinou, Andreas I.; Grdina, D.; Kiguchi, K.; Huberman, E. (1992)
      Treatment of human K-562-J leukemia cells for 1 h with the topoisomerase II-reactive drugs VP-16, VM-26, or mAMSA resulted in a dose-dependent inhibition of proliferation and in an increase in the percentage of cells ...

    • Article  

      Flavonoids as DNA topoisomerase antagonists and poisons: Structure-activity relationships 

      Constantinou, Andreas I.; Mehta, R.; Runyan, C.; Rao, K.; Vaughan, A.; Moon, R. (1995)
      Selected flavonoids were tested for their ability to inhibit the catalytic activity of DNA topoisomerase (topo) I and II. Myricetin, quercetin, fisetin, and morin were found to inhibit both enzymes, while phloretin, ...

    • Article  

      Induction of Differentiation and DNA Strand Breakage in Human HL-60 and K-562 Leukemia Cells by Genistein 

      Constantinou, Andreas I.; Kiguchi, K.; Huberman, E. (1990)
      Genistein, an in vitro inhibitor of topoisomerase II and tyrosine kinases, suppressed growth and induced differentiation in HL-205 cells, a clonal population of the human promyelocytic HL-60 leukemia cells, and in K-562-J ...

    • Article  

      Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones 

      Constantinou, Andreas I.; Mehta, R. G.; Vaughan, A. (1996)
      Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against breast and prostate cancer. Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against ...

    • Article  

      Inhibition of topoisomerase IIα activity in CHO K1 cells by 2- [(aminopropyl)amino]ethanethiol (WR-1065) 

      Grdina, D. J.; Constantinou, Andreas I.; Shigematsu, N.; Murley, J. S. (1994)
      The aminothiol 2-[(aminopropyl)amino]ethanethiol (WR-1065) is the active thiol of the clinically studied radioprotective agent S-2-(3- aminopropylamino)ethylphosphorothioic acid (WR-2721). WR-1065 is an effective radiation ...

    • Article  

      Involvement of host DNA gyrase in growth of bacteriophage T5 

      Constantinou, Andreas I.; Voelkel-Meiman, K.; Sternglanz, R.; McCorquodale, M. M.; McCorquodale, D. J. (1986)
      Bacteriophage T5 did not grow at the nonpermissive temperature of 42°C in Escherichia coli carrying a temperature-sensitive mutation in gyrB [gyrB(Ts)], but it did grow in gyrA(Ts) mutants at 42°C. These findings indicate ...

    • Article  

      Novobiocin- and Phorbol-12-myristate-13-acetate-induced Differentiation of Human Leukemia Cells Associated with a Reduction in Topoisomerase II Activity 

      Constantinou, Andreas I.; Henning-Chubb, C.; Huberman, E. (1989)
      Studies were conducted to determine the possible involvement of DNA topoisomerase II (Topo II) in the induction of differentiation in two human promyelocytic HL-60 leukemia cell variants that are either susceptible or ...

    • Article  

      Resistance to etoposide in human leukemia HL-60 cells: Reduction in drug-induced DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides 

      Ganapathi, R.; Constantinou, Andreas I.; Kamath, N.; Dubyak, G.; Grabowski, D.; Krivacic, K. (1996)
      Tumor cell resistance to anthracyclines and epipodophyllotoxins can be due to reduced drug accumulation and/or alterations in the activity of topoisomerase II (TOPO II). HL-60 cells selected in 0.05 μg/ml doxorubicin (DOX) ...

    • Article  

      WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells 

      Murley, J. S.; Constantinou, Andreas I.; Kamath, N. S.; Grdina, D. J. (1997)
      The effects of WR-1065 (2-((aminopropyl)amino)ethanethiol) on cell cycle progression, topoisomerase (topo) IIα activity, and topo IIα phosphorylation in Chinese hamster ovary (CHO) cells have been investigated. Exposure ...

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