Browsing by Subject "drug delivery system"
Now showing items 1-20 of 26
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Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model
(2013)Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...
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Combining two strategies to improve perfusion and drug delivery in solid tumors
(2013)Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a ...
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Delivering nanomedicine to solid tumors
(2010)Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using nanoparticles to treat ...
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Delivery of molecular and nanoscale medicine to tumors: Transport barriers and strategies
(2011)Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport ...
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Design considerations for nanotherapeutics in oncology
(2015)Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing the adverse effects of chemotherapeutic agents, but improvements in overall survival are modest. This is in large part due to the ...
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Electrohydrodynamic methods for the development of pulmonary drug delivery systems
(2018)Electrospinning and electrospraying are two highly versatile and scalable electrohydrodynamic methods, which have attracted considerable attention during the last years towards the fabrication of polymer-based drug delivery ...
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Fabrication, characterization, and evaluation in drug release properties of magnetoactive poly(ethylene oxide)-poly(l -lactide) electrospun membranes
(2013)The fabrication of electrospun magnetoactive fibrous nanocomposite membranes based on the water-soluble and biocompatible poly(ethylene oxide) (PEO), the biocompatible and biodegradable poly(l-lactide) (PLLA) and preformed ...
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In silico assessment of mouth-throat effects on regional deposition in the upper tracheobronchial airways
(2018)Regional deposition of inhaled medicines is a valuable metric of effectiveness in drug delivery applications to the lung. In silico methods are now emerging as a valuable tool for the detailed description of localized ...
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Multiresponsive polymer conetworks capable of responding to changes in pH, temperature, and magnetic field: Synthesis, characterization, and evaluation of their ability for controlled uptake and release of solutes
(2012)This study deals with the preparation of novel multiresponsive (magnetoresponsive, thermoresponsive and pH-responsive) nanocomposite conetworks consisting of oleic acid-coated magnetite nanoparticles (OA•Fe 3O 4), ...
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Multistage nanoparticle delivery system for deep penetration into tumor tissue
(2011)Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...
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Multistage nanoparticles for improved delivery into tumor tissue
(2012)The enhanced permeability and retention (EPR) effect has been a key rationale for the development of nanoscale carriers to solid tumors. As a consequence of EPR, nanotherapeutics are expected to improve drug and detection ...
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Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
(2012)The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic ...
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Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy
(2018)[Figure presented] A solid tumor is like an aberrant organ – comprised of cancer cells and a variety of host cells embedded in an extracellular matrix – nourished by blood vessels and drained by lymphatic vessels. In its ...
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Regional aerosol deposition in the human airways: The SimInhale benchmark case and a critical assessment of in silico methods
(2018)Regional deposition effects are important in the pulmonary delivery of drugs intended for the topical treatment of respiratory ailments. They also play a critical role in the systemic delivery of drugs with limited lung ...
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The role of mechanical forces in tumor growth and therapy
(2014)Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...
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Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review)
(2015)Deregulation of cell signaling homeostasis is a predominant feature of cancer initiation and progression. Transforming growth factor β (TGFβ) is a pleiotropic cytokine, which regulates numerous biological processes of ...
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Scaling rules for diffusive drug delivery in tumor and normal tissues
(2011)Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that ...
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The Solid Mechanics of Cancer and Strategies for Improved Therapy
(2017)Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...