Browsing by Subject "embryonic stem cell"
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Alport syndrome from bench to bedside: The potential of current treatment beyond RAAS blockade and the horizon of future therapies
(2014)The hereditary type IV collagen disease Alport syndrome (AS) always leads to end-stage renal failure. Yesterday, for the past 90 years, this course was described as 'inevitable'. Today, RAAS blockade has changed the ...
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Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes
(2016)The insufficient ability of specialized cells such as neurons, cardiac myocytes, and epidermal cells to regenerate after tissue damage poses a great challenge to treat devastating injuries and ailments. Recent studies ...
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Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis
(2010)Adult structures in holometabolous insects such as Drosophila are generated by groups of imaginal cells dedicated to the formation of different organs. Imaginal cells are specified in the embryo and remain quiescent until ...
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The Polycomb Group Protein SUZ12 regulates histone H3 lysine 9 methylation and HP1α distribution
(2007)Regulation of histone methylation is critical for proper gene expression and chromosome function. Suppressor of Zeste 12 (SUZ12) is a requisite member of the EED/EZH2 histone methyltransferase complexes, and is required ...
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Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells
(2009)Telomere shortening is associated with organismal aging. iPS cells have been recently derived from old patients