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Browsing by Subject "focal adhesion kinase"

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    • Article  

      Activation of endogenous FAK via expression of its amino terminal domain in xenopus embryos 

      Petridou, Nicoletta I.; Stylianou, Panayiota; Christodoulou, Neophytos; Rhoads, Daniel S.; Guan, Junlin; Skourides, Paris A. (2012)
      Background: The Focal Adhesion Kinase is a well studied tyrosine kinase involved in a wide number of cellular processes including cell adhesion and migration. It has also been shown to play important roles during embryonic ...

    • Article  

      Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways 

      Koupepidou, P.; Felekkis, Kyriacos N.; Kränzlin, B.; Sticht, C.; Gretz, N.; Constantinou-Deltas, Constantinos D. (2010)
      Background: Polycystic Kidney Disease is characterized by the formation of large fluid-filled cysts that eventually destroy the renal parenchyma leading to end-stage renal failure. Although remarkable progress has been ...

    • Article  

      A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis 

      Petridou, Nicoletta I.; Stylianou, Panayiota; Skourides, Paris A. (2013)
      FAK is a non-receptor tyrosine kinase involved in a wide variety of biological processes and crucial for embryonic development. In this manuscript, we report the generation of a new FAK dominant negative (FF), composed of ...

    • Article  

      FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis 

      Petridou, Nicoletta I.; Skourides, Paris A. (2014)
      Spindle orientation is critical for proper morphogenesis of organs and tissues as well as for the maintenance of tissue morphology. Although significant progress has been made in understanding the mechanisms linking the ...

    • Article  

      Imaging morphogenesis, in Xenopus with Quantum Dot nanocrystals 

      Stylianou, Panayiota; Skourides, Paris A. (2009)
      Mesoderm migration is a well studied morphogenetic movement that takes place during Xenopus gastrulation. The study of mesoderm migration and other morphogenetic movements has been primarily based on in vitro assays due ...

    • Article  

      Making the Connection: Ciliary Adhesion Complexes Anchor Basal Bodies to the Actin Cytoskeleton 

      Antoniades, Ioanna; Stylianou, Panayiota; Skourides, Paris A. (2014)
      Cilia have been associated with diverse developmental and physiological processes, and defects in cilia underlie a number of genetic conditions. Several lines of evidence support a critical role of the actin cytoskeleton ...

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