Browsing by Subject "focal adhesion kinase"

Article

Activation of endogenous FAK via expression of its amino terminal domain in xenopus embryos

Petridou, Nicoletta I.; Stylianou, Panayiota; Christodoulou, Neophytos; Rhoads, Daniel S.; Guan, Junlin; Skourides, Paris A. (2012)

Background: The Focal Adhesion Kinase is a well studied tyrosine kinase involved in a wide number of cellular processes including cell adhesion and migration. It has also been shown to play important roles during embryonic ...

Article

Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways

Koupepidou, P.; Felekkis, Kyriacos N.; Kränzlin, B.; Sticht, C.; Gretz, N.; Constantinou-Deltas, Constantinos D. (2010)

Background: Polycystic Kidney Disease is characterized by the formation of large fluid-filled cysts that eventually destroy the renal parenchyma leading to end-stage renal failure. Although remarkable progress has been ...

Article

A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis

Petridou, Nicoletta I.; Stylianou, Panayiota; Skourides, Paris A. (2013)

FAK is a non-receptor tyrosine kinase involved in a wide variety of biological processes and crucial for embryonic development. In this manuscript, we report the generation of a new FAK dominant negative (FF), composed of ...

Article

FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis

Petridou, Nicoletta I.; Skourides, Paris A. (2014)

Spindle orientation is critical for proper morphogenesis of organs and tissues as well as for the maintenance of tissue morphology. Although significant progress has been made in understanding the mechanisms linking the ...

Article

Imaging morphogenesis, in Xenopus with Quantum Dot nanocrystals

Stylianou, Panayiota; Skourides, Paris A. (2009)

Mesoderm migration is a well studied morphogenetic movement that takes place during Xenopus gastrulation. The study of mesoderm migration and other morphogenetic movements has been primarily based on in vitro assays due ...

Article

Making the Connection: Ciliary Adhesion Complexes Anchor Basal Bodies to the Actin Cytoskeleton

Antoniades, Ioanna; Stylianou, Panayiota; Skourides, Paris A. (2014)

Cilia have been associated with diverse developmental and physiological processes, and defects in cilia underlie a number of genetic conditions. Several lines of evidence support a critical role of the actin cytoskeleton ...