Browsing by Subject "gene expression regulation"

Article

Beyond the histone tail: acetylation at the nucleosome dyad commands transcription.

Molina-Serrano, D.; Kirmizis, Antonis (2013)

Post-translational modifications (PTMs) of histones have been implicated in cellular processes such as transcription, replication and DNA repair. These processes normally involve dynamic changes in chromatin structure and ...

Article

Comparative developmental anatomy of the murine and human definitive placentae

Georgiades, Pantelis; Fergyson-Smith, A. C.; Burton, G. J. (2002)

The placenta of eutherian mammals is a remarkable biological structure. It is composed of both zygote-derived and maternal cells, and mediates the complex interactions between the mother and the fetus that are necessary ...

Article

Delta-like and Gtl2 are reciprocally expressed differentially methylated linked imprinted genes on mouse chromosome 12

Takada, S.; Tevendale, M.; Baker, J.; Georgiades, Pantelis; Campbell, E.; Freeman, T.; Johnson, M. H.; Paulsen, M.; Ferguson-Smith, A. C. (2000)

The distal portion of mouse chromosome 12 is imprinted. To date, however, Gtl2 is the only imprinted gene identified on chromosome 12. Gtl2 encodes multiple alternatively spliced transcripts with no apparent open reading ...

Article

Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes

Iacovides, D.; Rizki, G.; Lapathitis, Georgios; Strati, K. (2016)

The insufficient ability of specialized cells such as neurons, cardiac myocytes, and epidermal cells to regenerate after tissue damage poses a great challenge to treat devastating injuries and ailments. Recent studies ...

Article

Genomic approaches that aid in the identification of transcription factor target genes

Kirmizis, Antonis; Farnham, P. J. (2004)

It is well-established that deregulation of the transcriptional activity of many different genes has been causatively linked to human diseases. In cancer, altered patterns of gene expression are often the result of the ...

Article

Homeostatic interplay between bacterial cell-cell signaling and iron in virulence

Hazan, R.; He, J.; Xiao, G.; Dekimpe, V.; Apidianakis, Yiorgos; Lesic, B.; Astrakas, C.; Déziel, Eric; Lépine, F.; Rahme, L. G. (2010)

Pathogenic bacteria use interconnected multi-layered regulatory networks, such as quorum sensing (QS) networks to sense and respond to environmental cues and external and internal bacterial cell signals, and thereby adapt ...

Article

Identification of Ras suppressor-1 (RSU-1) as a potential breast cancer metastasis biomarker using a three-dimensional in vitro approach

Gkretsi, V.; Stylianou, A.; Louca, M.; Stylianopoulos, T. (2017)

Breast cancer (BC) is the most common malignant disease in women, with most patients dying from metastasis to distant organs, making discovery of novel metastasis biomarkers and therapeutic targets imperative. Extracellular ...

Article

Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma

Apidianakis, Yiorgos; Mindrinos, M. N.; Xiao, W.; Tegos, G. P.; Papisov, M. I.; Hamblin, M. R.; Davis, R. W.; Tompkins, R. G.; Rahme, L. G. (2007)

Despite recent advances in our understanding the pathophysiology of trauma, the basis of the predisposition of trauma patients to infection remains unclear. A Drosophila melanogaster/Pseudomonas aeruginosa injury and ...

Article

KIF2β, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation

Santama, Niovi; Krijnse-Ĺocker, J.; Griffiths, G.; Noda, Y.; Hirokawa, N.; Dotti, C. G. (1998)

Lysosomes concentrate juxtanuclearly in the region around the microtubule-organizing center by interaction with microtubules. Different experimental and physiological conditions can induce these organelles to move to the ...

Article

Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity

Molina-Serrano, D.; Schiza, V.; Demosthenous, Christis; Stavrou, Emmanouil; Oppelt, J.; Kyriakou, DImitris; Liu, W.; Zisser, G.; Bergler, H.; Dang, W.; Kirmizis, Antonis (2016)

Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary interventions with ...

Article

A miR-1207-5p binding site polymorphism abolishes regulation of HBEGF and is associated with disease severity in CFHR5 nephropathy

Papagregoriou, Gregory N.; Erguler, K.; Dweep, H.; Voskarides, Konstantinos; Koupepidou, P.; Athanasiou, Yiannis; Pierides, Alkis M.; Gretz, N.; Felekkis, Kyriacos N.; Constantinou-Deltas, Constantinos D. (2012)

Heparin binding epidermal growth factor (HBEGF) is expressed in podocytes and was shown to play a role in glomerular physiology. MicroRNA binding sites on the 3′UTR of HBEGF were predicted using miRWalk algorithm and ...

Article

The mouse Foxi3 transcription factor is necessary for the development of posterior placodes

Birol, O.; Ohyama, T.; Edlund, R. K.; Drakou, Katerina; Georgiades, Pantelis; Groves, A. K. (2016)

The inner ear develops from the otic placode, one of the cranial placodes that arise from a region of ectoderm adjacent to the anterior neural plate called the pre-placodal domain. We have identified a Forkhead family ...

Article

Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2

Felekkis, Kyriacos N.; Koupepidou, P.; Kastanos, E.; Witzgall, R.; Bai, C. -X; Li, L.; Tsiokas, L.; Gretz, N.; Constantinou-Deltas, Constantinos D. (2008)

Background. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in genes ...

Article

New Insights for Ets2 Function in Trophoblast using Lentivirus-Mediated Gene Knockdown in Trophoblast Stem Cells

Odiatis, C.; Georgiades, Pantelis (2010)

Mouse trophoblast stem (TS) cells represent a unique in vitro system that provides an unlimited supply of TS cells for the study of trophoblast differentiation and TS cell self-renewal. Although the mouse transcription ...

Article

New miRNA profiles accurately distinguish renal cell carcinomas and upper tract urothelial carcinomas from the normal kidney

Zaravinos, Apostolos; Lambrou, George I.; Mourmouras, Nikos; Katafygiotis, Patroklos; Papagregoriou, Gregory N.; Giannikou, Krinio; Delakas, Dimitrios S.; Constantinou-Deltas, Constantinos D. (2014)

Background: Upper tract urothelial carcinomas (UT-UC) can invade the pelvicalyceal system making differential diagnosis of the various histologically distinct renal cell carcinoma (RCC) subtypes and UT-UC, difficult. Correct ...

Article

Overexpression of the m4 and mα genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition

Apidianakis, Yiorgos; Nagel, A. C.; Chalkiadaki, Angeliki; Preiss, A.; Delidakis, Christos (1999)

Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and ...

Article

The pathogenic properties of a novel and conserved gene product, KerV, in proteobacteria

An, D.; Apidianakis, Yiorgos; Boechat, A. L.; Baldini, R. L.; Goumnerov, B. C.; Rahme, L. G. (2009)

Identification of novel virulence factors is essential for understanding bacterial pathogenesis and designing antibacterial strategies. In this study, we uncover such a factor, termed KerV, in Proteobacteria. Experiments ...

Article

Pirfenidone normalizes the tumor microenvironment to improve chemotherapy

Polydorou, C.; Mpekris, F.; Papageorgis, P.; Voutouri, C.; Stylianopoulos, T. (2017)

Normalization of the tumor microenvironment by selectively targeting components of the tumor extracellular matrix has been recently proposed to have the potential to decompress tumor blood vessels, increase vessel perfusion ...

Article

Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimocrobial peptide gene expression

Apidianakis, Yiorgos; Mindrinos, M. N.; Xiao, W.; Lau, G. W.; Baldini, R. L.; Davis, R. W.; Rahme, L. G. (2005)

Insights into the host factors and mechanisms mediating the primary host responses after pathogen presentation remain limited, due in part to the complexity and genetic intractability of host systems. Here, we employ the ...

Article

A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes

Kesarwani, M.; Hazan, R.; He, J.; Que, Y.; Apidianakis, Yiorgos; Lesic, B.; Xiao, G.; Dekimpe, V.; Milot, S.; Déziel, Eric; Lépine, F.; Rahme, L. G. (2011)

A significant number of environmental microorganisms can cause serious, even fatal, acute and chronic infections in humans. The severity and outcome of each type of infection depends on the expression of specific bacterial ...