Browsing by Subject "genetic transcription"

Article

Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation

Kirmizis, Antonis; Santos-Rosa, H.; Penkett, C. J.; Singer, M. A.; Vermeulen, M.; Mann, M.; Bähler, J.; Green, R. D.; Kouzarides, T. (2007)

Modifications on histones control important biological processes through their effects on chromatin structure. Methylation at lysine 4 on histone H3 (H3K4) is found at the 5′ end of active genes and contributes to ...

Article

Differential expression of the rat retinoid X receptor γ gene during skeletal muscle differentiation suggests a role in myogenesis

Georgiades, Pantelis; Brickell, P. M. (1997)

Even though previous studies have shown that transcripts encoding the murine retinoid X receptor γ (RXRγ) are present in skeletal muscle of mouse embryos and that cultured myoblasts are induced to differentiate upon retinoid ...

Article

Histone H3 tail clipping regulates gene expression

Santos-Rosa, H.; Kirmizis, Antonis; Nelson, C.; Bartke, T.; Saksouk, N.; Cote, J.; Kouzarides, T. (2009)

Induction of gene expression in yeast and human cells involves changes in the histone modifications associated with promoters. Here we identify a histone H3 endopeptidase activity in Saccharomyces cerevisiae that may ...

Article

Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy

Kirmizis, Antonis; Bartley, S. M.; Farnham, P. J. (2003)

We have previously identified SU(Z)12 as an E2F target gene. Because many E2F target genes encode proteins that are critical for the control of cell proliferation, we have further characterized the regulation and expression ...

Article

MicroRNAs: A newly described class of encoded molecules that play a role in health and disease

Felekkis, Kyriacos N.; Touvana, Evi; Stefanou, Charalambos; Constantinou-Deltas, Constantinos D. (2010)

14(4): 236-240.

Article

Overexpression of the m4 and mα genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition

Apidianakis, Yiorgos; Nagel, A. C.; Chalkiadaki, Angeliki; Preiss, A.; Delidakis, Christos (1999)

Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and ...

Article

Regulation of Lactate Dehydrogenase Gene Expression by AMP‐dependent Protein Kinase Subunits

JUNGMANN, R. A.; Constantinou, Andreas I.; SQUINTO, S. P.; KWAST‐WELFELD, J.; SCHWEPPE, J. S. (1986)

Article

Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis

Papageorgis, P.; Ozturk, S.; Lambert, A. W.; Neophytou, Christiana M.; Tzatsos, Alexandros; Wong, C. K.; Thiagalingam, S.; Constantinou, Andreas I. (2015)

Introduction: Basal-like breast cancer (BLBC) is an aggressive subtype often characterized by distant metastasis, poor patient prognosis, and limited treatment options. Therefore, the discovery of alternative targets to ...