Browsing by Subject "genistein"

Article

Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats

Constantinou, Andreas I.; Lantvit, D.; Hawthorne, M.; Xu, X.; Van Breemen, R. B.; Pezzuto, J. M. (2001)

There are conflicting reports on the effect of soy and its components on mammary carcinogenesis in adult female rats, mainly because of different rodent models that are used in chemoprevention studies. The present study ...

Article

The effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D/PKCα

Tonetti, D. A.; Zhang, Y.; Zhao, H.; Lim, S. -B; Constantinou, Andreas I. (2007)

Soy supplements are often consumed by women for alleviating menopausal symptoms or for the perceived protective effects against breast cancer. More concerning is the concurrent consumption of soy isoflavones with tamoxifen ...

Article

Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms

Liu, J.; Burdette, J. E.; Xu, H.; Gu, C.; Van Breemen, R. B.; Bhat, K. P. L.; Booth, N.; Constantinou, Andreas I.; Pezzuto, J. M.; Fong, H. H. S.; Farnsworth, N. R.; Bolton, J. L. (2001)

Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus ...

Article

Flavonoids as DNA topoisomerase antagonists and poisons: Structure-activity relationships

Constantinou, Andreas I.; Mehta, R.; Runyan, C.; Rao, K.; Vaughan, A.; Moon, R. (1995)

Selected flavonoids were tested for their ability to inhibit the catalytic activity of DNA topoisomerase (topo) I and II. Myricetin, quercetin, fisetin, and morin were found to inhibit both enzymes, while phloretin, ...

Article

Genistein as an Inducer of Tumor Cell Differentiation: Possible Mechanisms of Action

Constantinou, Andreas I.; Huberman, E. (1995)

Decreased activity of either topoisomerases or tyrosine kinases has been implicated in the differentiation of a number of cell types. It is therefore conceivable that genistein, because of its reported ability to inhibit ...

Article

Genistein-induced cell differentiation and protein-linked DNA strand breakage in human melanoma cells

Kiguchi, K.; Constantinou, Andreas I.; Huberman, E. (1990)

Article

Induction of Differentiation and DNA Strand Breakage in Human HL-60 and K-562 Leukemia Cells by Genistein

Constantinou, Andreas I.; Kiguchi, K.; Huberman, E. (1990)

Genistein, an in vitro inhibitor of topoisomerase II and tyrosine kinases, suppressed growth and induced differentiation in HL-205 cells, a clonal population of the human promyelocytic HL-60 leukemia cells, and in K-562-J ...

Article

Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones

Constantinou, Andreas I.; Mehta, R. G.; Vaughan, A. (1996)

Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against breast and prostate cancer. Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against ...

Article

Isolation of isoflavones from soy-based fermentations of the erythromycin-producing bacterium Saccharopolyspora erythraea

Hessler, P. E.; Larsen, P. E.; Constantinou, Andreas I.; Schram, K. H.; Weber, J. M. (1997)

A search for an abundant and economical source of isoflavones, particularly genistein, led to the discovery that the erythromycin-producing organism Saccharopolyspora erythraea also produces this promising new cancer-prevention ...

Article

Point-counterpoint: Soy intake for breast cancer patients

Block, K. I.; Constantinou, Andreas I.; Hilakivi-Clarke, L.; Hughes, C.; Tripathy, D.; Tice, J. A. (2002)

Article

Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity

Cho, K. H.; Pezzuto, J. M.; Bolton, J. L.; Steele, V. E.; Kelloff, G. J.; Lee, S. K.; Constantinou, Andreas I. (2000)

The present study was undertaken to determine if in vitro inhibition of one or both of the two most dominant mammalian DNA topoisomerases (topos) is common among chemopreventive agents. To determine if an agent was a topo ...

Article

Targeting colon cancer cells with genistein-17.1A immunoconjugate.

Gentile, M. S.; Vasu, C.; Green, A.; Murillo, G.; Das Gupta, T. K.; Constantinou, Andreas I.; Prabhakar, B. S.; Salti, G. I. (2003)

We have shown that genistein, a major component of soy, has anti-colon cancer effects in vitro. These effects are attainable at high concentrations that are difficult to achieve in the serum. The purpose of this study was ...