Browsing by Subject "genomics"
Now showing items 1-4 of 4
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Article
1,2,3-Dithiazoles-new reversible melanin synthesis inhibitors: A chemical genomics study
(2015)A chemical genomic screen of an in-house library of small molecule heterocycles was carried out using Xenopus laevis embryos. This led to the identification of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methoxyaniline ...
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Article
DNA variant databases improve test accuracy and phenotype prediction in Alport syndrome
(2014)X-linked Alport syndrome is a form of progressive renal failure caused by pathogenic variants in the COL4A5 gene. More than 700 variants have been described and a further 400 are estimated to be known to individual ...
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Genomic approaches that aid in the identification of transcription factor target genes
(2004)It is well-established that deregulation of the transcriptional activity of many different genes has been causatively linked to human diseases. In cancer, altered patterns of gene expression are often the result of the ...
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A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
(2009)The reprogramming of differentiated cells to pluripotent cells (induced pluripotent stem (iPS) cells) is known to be an inefficient process. We recently reported that cells with short telomeres cannot be reprogrammed to ...