Browsing by Subject "glioblastoma"
Now showing items 1-4 of 4
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Article
Combining two strategies to improve perfusion and drug delivery in solid tumors
(2013)Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a ...
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Article
Defining the role of solid stress and matrix stiffness in cancer cell proliferation and metastasis
(2018)Solid tumors are characterized by an abnormal stroma that contributes to the development of biomechanical abnormalities in the tumor microenvironment. In particular, these abnormalities include an increase in matrix stiffness ...
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Article
Remodeling components of the tumor microenvironment to enhance cancer therapy
(2015)Solid tumor pathophysiology is characterized by an abnormal microenvironment that guides tumor progression and poses barriers to the efficacy of cancer therapies. Most common among tumor types are abnormalities in the ...
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Article
The role of mechanical forces in tumor growth and therapy
(2014)Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...