Browsing by Subject "human"

Article

The 1.76 Å resolution crystal structure of glycogen phosphorylase b complexed with glucose, and CP320626, a potential antidiabetic drug

Oikonomakos, Nikos G.; Zographos, Spyros E.; Skamnaki, Vicky T.; Archontis, Georgios Z. (2002)

CP320626, a potential antidiabetic drug, inhibits glycogen phosphorylase in synergism with glucose. To elucidate the structural basis of synergistic inhibition, we determined the structure of muscle glycogen phosphorylase ...

Article

2nd combined working group and management committee meeting of urine and kidney proteomics COST action 29-30 March 2009, Nafplio, Greece

Vlahou, Antonia; Allmaier, G.; Attwood, T.; Bongcam-Rudloff, E.; Charonis, Aristidis S.; Frokiaer, J.; Mischak, H.; Schanstra, J.; Spasovski, G.; Aasberg, A.; Allory, Y.; Arthur, J.; Attwood, T.; Banks, R.; Baumann, M.; Benigni, A.; Bezerianos, Anastasios; Campistol, J. M.; Candiano, G.; Capasso, G.; Carpentier, S.; Dadlez, M.; Constantinou-Deltas, Constantinos D.; Dijilianov, D.; De Zeeuw, D.; Decramer, S.; Dihazi, H.; Domon, B.; Endlich, N.; d'Alche-Buc, F.; D'Haese, P.; Edelman, A.; Egido, J.; El Nahas, M.; Farinazzo, A.; Fernandez-Llama, P.; Feldt-Rasmussen, B.; Frokiaer, J.; Gansevoort, R.; Garbis, S.; Garin, J.; Ghiggeri, G. M.; Gimenez, I.; Granier, C.; Goumenos, Dimitrios S.; Haylor, J. L.; Hilario, M.; Holthofer, H.; Kalousis, Alexandros; Kaski, S.; Knepper, M.; Korneti, P.; Kossida, Sophia A.; Langham, R.; Loftheim, H.; Lopez-Novoa, J.; Luider, T.; Magni, F.; Malats, N.; Martin, J. L.; Mayrhofer, C.; Monsarrat, B.; Mueller, G.; Nielsen, S.; Norling, M.; O'Connell, S.; Ortiz, A.; Perunicic-Pekovic, G.; Planelles, G.; Polenakovic, M.; Promponas, Vasilis J.; Rasic-Milutinovic, Z.; Rehulka, P.; Peter, K.; Righetti, P. G.; Ronco, P.; Ryan, M.; Sánchez-Carbayo, M.; Schanstra, J.; Semmes, J.; Sheehan, D.; Stenman, U. -H; Stodkilde-Jorgensen, L.; Tasic, V.; Theodorescu, D.; Thongboonkerd, V.; Toncheva, D.; Tsillibari, E.; Tsiotis, Georgios; Unwin, R.; Vanholder, R.; Vassilev, D.; Vickers, M. E.; Verhulst, A.; Vilasi, Annalisa; Vlahakos, D.; Vonk, R.; Wright, P. C.; Yamamoto, Tadashi; Yutaka, Y.; Zielenkiewicz, P. (2009)

EuroKUP (Urine and Kidney Proteomics

Article

The A and B fragments of normal type I procollagen have a similar thermal stability to proteinase digestion but are selectively destabilized by structural mutations

Constantinou-Deltas, Constantinos D.; VOGEL, B. E.; JEFFREY, J. J.; PROCKOP, D. J. (1987)

Previous studies demonstrated that the thermal stability of the procollagen triple helix can be assayed by digesting the protein for short periods with high concentrations of trypsin and chymotrypsin. Here we cleaved human ...

Article

A ligand-independent integrin β1 mechanosensory complex guides spindle orientation

Petridou, Nicoletta I.; Skourides, Paris A. (2016)

Control of spindle orientation is a fundamental process for embryonic development, morphogenesis and tissue homeostasis, while defects are associated with tumorigenesis and other diseases. Force sensing is one of the ...

Conference Object

Adaptive emergency scenery video communications using HEVC for responsive decision support in disaster incidents

Antoniou, Zinonas C.; Panayides, Andreas S.; Pattichis, Marios S.; Stavrou, S.; Kyriacou, Efthyvoulos C.; Spanias, Andreas S.; Constantinides, Anthony G.; Pattichis, Constantinos S. (Institute of Electrical and Electronics Engineers Inc., 2015)

This study proposes a unifying framework for m-Health video communication systems that provides for the joint optimization of video quality, bitrate demands, and encoding time. The framework is video modality and infrastructure ...

Article

Algorithmic mechanisms for reliable crowdsourcing computation under collusion

Fernández Anta, Antonio; Georgiou, Chryssis; Mosteiro, Miguel A.; Pareja, D. (2015)

We consider a computing system where a master processor assigns a task for execution to worker processors that may collude. We model the workers' decision of whether to comply (compute the task) or not (return a bogus ...

Article

Allele distribution of 15 STR loci used for human identity purposes in the Greek Cypriot population of the island of Cyprus

Cariolou, Marios A.; Manoli, Panayiotis; Demetriou, Neophytos; Bashiardes, Evy; Karagrigoriou, Alex; Budowle, Bruce (2006)

Allele frequencies for 15 STRs (D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, THO1, Penta E, D16S539, CSF1PO, Penta D and TPOX) in the PowerPlex®-16 System (Promega Corporation) were derived from a ...

Article

Alport syndrome from bench to bedside: The potential of current treatment beyond RAAS blockade and the horizon of future therapies

Gross, O.; Perin, L.; Constantinou-Deltas, Constantinos D. (2014)

The hereditary type IV collagen disease Alport syndrome (AS) always leads to end-stage renal failure. Yesterday, for the past 90 years, this course was described as 'inevitable'. Today, RAAS blockade has changed the ...

Article

Altered Phosphorylation, Biosynthesis and Degradation of the 170 kDa Isoform of Topoisomerase II in Amsacrine-Resistant Human Leukemia Cells

Ganapathi, R.; Zwelling, L.; Constantinou, Andreas I.; Ford, J.; Grabowski, D. (1993)

Resistance to amsacrine in HL-60/AMSA is 50-100 fold compared to the parental HL-60/S cells. Synthesis and phosphorylation of topoisomerase II (TOPO II) were 2-3 fold lower in HL-60/AMSA compared to HL-60/S cells metabolically ...

Article

AM-FM texture segmentation in electron microscopic muscle imaging

Pattichis, Marios S.; Pattichis, Constantinos S.; Avraam, Maria; Bovik, Alan Conrad; Kyriacou, Kyriacos C. (2000)

This paper describes the application of an amplitude modulation-frequency modulation (AM-FM) image representation in segmenting electron micrographs of skeletal muscle for the recognition of: 1) normal sarcomere ultrastructural ...

Article

Analysis of expired air of fasting male monks at Mount Athos

Statheropoulos, Miltiades K.; Agapiou, Agapios; Georgiadou, A. (2006)

Expired air chemical analysis is investigated as a search and locate method for the early detection of entrapped people under the ruins of collapsed buildings after an earthquake. Fasting individuals were examined as a ...

Article

Analysis of published PKD1 gene sequence variants [3]

Gout, A. M.; Ravine, D.; Harris, Peter C.; Rossetti, S.; Peters, D.; Breuning, M.; Henske, E. P.; Koizumi, A.; Inoue, S.; Shimizu, Y.; Thongnoppakhun, W.; Yenchitsomanus, P. -T; Constantinou-Deltas, Constantinos D.; Sandford, R.; Torra, R.; Turco, A. E.; Jeffery, S.; Fontes, M.; Somlo, Stefan; Furu, L. M.; Smulders, Y. M.; Mercier, B.; Ferec, C.; Burtey, S.; Pei, Y.; Kalaydjieva, L.; Bogdanova, N.; McCluskey, M.; Geon, L. J.; Wouters, C. H.; Reiterova, J.; Stekrová, J.; San Millan, J. L.; Aguiari, G.; Senno, L. D. (2007)

Article

Analysis of volatile organic compounds released from the decay of surrogate human models simulating victims of collapsed buildings by thermal desorption-comprehensive two-dimensional gas chromatography-time of flight mass spectrometry

Agapiou, Agapios; Zorba, Eleni; Mikedi, Katerina; McGregor, L.; Spiliopoulou, C.; Statheropoulos, Miltiades K. (2015)

Field experiments were devised to mimic the entrapment conditions under the rubble of collapsed buildings aiming to investigate the evolution of volatile organic compounds (VOCs) during the early dead body decomposition ...

Article

Application of ion mobility spectrometry for the detection of human urine

Rudnicka, J.; Mochalski, Paweł; Agapiou, Agapios; Statheropoulos, Miltiades K.; Amann, Anton; Buszewski, B. (2010)

The aim of the present study was to evaluate the suitability of ion mobility spectrometry (IMS) for the detection of human urine as an indication of human presence during urban search and rescue operations in collapsed ...

Article

Architectural insight into inovirus-associated vectors (IAVs) and development of IAV-based vaccines inducing humoral and cellular responses: Implications in HIV-1 vaccines

Hassapis, K. A.; Stylianou, Dora C.; Kostrikis, Leontios G. (2014)

Inovirus-associated vectors (IAVs) are engineered, non-lytic, filamentous bacteriophages that are assembled primarily from thousands of copies of the major coat protein gp8 and just five copies of each of the four minor ...

Article

Assessment of the risk factors of coronary heart events based on data mining with decision trees

Karaolis, Minas A.; Moutiris, Joseph Antoniou; Hadjipanayi, Demetra; Pattichis, Constantinos S. (2010)

Coronary heart disease (CHD) is one of the major causes of disability in adults as well as one of the main causes of death in the developed countries. Although significant progress has been made in the diagnosis and treatment ...

Article

Association rule analysis for the assessment of the risk of coronary heart events.

Karaolis, Minas A.; Moutiris, Joseph Antoniou; Papaconstantinou, L.; Pattichis, Constantinos S. (2009)

Although significant progress has been made in the diagnosis and treatment of coronary heart disease (CHD), further investigation is still needed. The objective of this study was to develop a data mining system using ...

Article

Atherosclerotic plaque ultrasound video encoding, wireless transmission, and quality assessment using H.264

Panayides, Andreas S.; Pattichis, Marios S.; Pattichis, Constantinos S.; Loizou, Christos P.; Pantzaris, Marios C.; Pitsillides, Andreas (2011)

We propose a unifying framework for efficient encoding, transmission, and quality assessment of atherosclerotic plaque ultrasound video. The approach is based on a spatially varying encoding scheme, where video-slice ...

Article

Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIα

Aoyama, M.; Grabowski, D. R.; Dubyak, G. R.; Constantinou, Andreas I.; Rybicki, L. A.; Bukowski, R. M.; Ganapathi, M. K.; Hickson, I. D.; Ganapathi, R. (1998)

Topoisomerase II (topo II), an essential enzyme for cell viability, is also the target for clinically important anti-neoplastic agents that stimulate topo II-mediated DNA scission. The role of alterations in topo IIα ...

Article

Authors' reply

Constantinou-Deltas, Constantinos D.; Voskarides, Konstantinos (2010)