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    • Article  

      The 1.76 Å resolution crystal structure of glycogen phosphorylase b complexed with glucose, and CP320626, a potential antidiabetic drug 

      Oikonomakos, Nikos G.; Zographos, Spyros E.; Skamnaki, Vicky T.; Archontis, Georgios Z. (2002)
      CP320626, a potential antidiabetic drug, inhibits glycogen phosphorylase in synergism with glucose. To elucidate the structural basis of synergistic inhibition, we determined the structure of muscle glycogen phosphorylase ...

    • Article  

      2nd combined working group and management committee meeting of urine and kidney proteomics COST action 29-30 March 2009, Nafplio, Greece 

      Vlahou, Antonia; Allmaier, G.; Attwood, T.; Bongcam-Rudloff, E.; Charonis, Aristidis S.; Frokiaer, J.; Mischak, H.; Schanstra, J.; Spasovski, G.; Aasberg, A.; Allory, Y.; Arthur, J.; Attwood, T.; Banks, R.; Baumann, M.; Benigni, A.; Bezerianos, Anastasios; Campistol, J. M.; Candiano, G.; Capasso, G.; Carpentier, S.; Dadlez, M.; Constantinou-Deltas, Constantinos D.; Dijilianov, D.; De Zeeuw, D.; Decramer, S.; Dihazi, H.; Domon, B.; Endlich, N.; d'Alche-Buc, F.; D'Haese, P.; Edelman, A.; Egido, J.; El Nahas, M.; Farinazzo, A.; Fernandez-Llama, P.; Feldt-Rasmussen, B.; Frokiaer, J.; Gansevoort, R.; Garbis, S.; Garin, J.; Ghiggeri, G. M.; Gimenez, I.; Granier, C.; Goumenos, Dimitrios S.; Haylor, J. L.; Hilario, M.; Holthofer, H.; Kalousis, Alexandros; Kaski, S.; Knepper, M.; Korneti, P.; Kossida, Sophia A.; Langham, R.; Loftheim, H.; Lopez-Novoa, J.; Luider, T.; Magni, F.; Malats, N.; Martin, J. L.; Mayrhofer, C.; Monsarrat, B.; Mueller, G.; Nielsen, S.; Norling, M.; O'Connell, S.; Ortiz, A.; Perunicic-Pekovic, G.; Planelles, G.; Polenakovic, M.; Promponas, Vasilis J.; Rasic-Milutinovic, Z.; Rehulka, P.; Peter, K.; Righetti, P. G.; Ronco, P.; Ryan, M.; Sánchez-Carbayo, M.; Schanstra, J.; Semmes, J.; Sheehan, D.; Stenman, U. -H; Stodkilde-Jorgensen, L.; Tasic, V.; Theodorescu, D.; Thongboonkerd, V.; Toncheva, D.; Tsillibari, E.; Tsiotis, Georgios; Unwin, R.; Vanholder, R.; Vassilev, D.; Vickers, M. E.; Verhulst, A.; Vilasi, Annalisa; Vlahakos, D.; Vonk, R.; Wright, P. C.; Yamamoto, Tadashi; Yutaka, Y.; Zielenkiewicz, P. (2009)
      EuroKUP (Urine and Kidney Proteomics

    • Article  

      The A and B fragments of normal type I procollagen have a similar thermal stability to proteinase digestion but are selectively destabilized by structural mutations 

      Constantinou-Deltas, Constantinos D.; VOGEL, B. E.; JEFFREY, J. J.; PROCKOP, D. J. (1987)
      Previous studies demonstrated that the thermal stability of the procollagen triple helix can be assayed by digesting the protein for short periods with high concentrations of trypsin and chymotrypsin. Here we cleaved human ...

    • Article  

      A ligand-independent integrin β1 mechanosensory complex guides spindle orientation 

      Petridou, Nicoletta I.; Skourides, Paris A. (2016)
      Control of spindle orientation is a fundamental process for embryonic development, morphogenesis and tissue homeostasis, while defects are associated with tumorigenesis and other diseases. Force sensing is one of the ...

    • Conference Object  

      Adaptive emergency scenery video communications using HEVC for responsive decision support in disaster incidents 

      Antoniou, Zinonas C.; Panayides, Andreas S.; Pattichis, Marios S.; Stavrou, S.; Kyriacou, Efthyvoulos C.; Spanias, Andreas S.; Constantinides, Anthony G.; Pattichis, Constantinos S. (Institute of Electrical and Electronics Engineers Inc., 2015)
      This study proposes a unifying framework for m-Health video communication systems that provides for the joint optimization of video quality, bitrate demands, and encoding time. The framework is video modality and infrastructure ...

    • Article  

      Algorithmic mechanisms for reliable crowdsourcing computation under collusion 

      Fernández Anta, Antonio; Georgiou, Chryssis; Mosteiro, Miguel A.; Pareja, D. (2015)
      We consider a computing system where a master processor assigns a task for execution to worker processors that may collude. We model the workers' decision of whether to comply (compute the task) or not (return a bogus ...

    • Article  

      Allele distribution of 15 STR loci used for human identity purposes in the Greek Cypriot population of the island of Cyprus 

      Cariolou, Marios A.; Manoli, Panayiotis; Demetriou, Neophytos; Bashiardes, Evy; Karagrigoriou, Alex; Budowle, Bruce (2006)
      Allele frequencies for 15 STRs (D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, THO1, Penta E, D16S539, CSF1PO, Penta D and TPOX) in the PowerPlex®-16 System (Promega Corporation) were derived from a ...

    • Article  

      Alport syndrome from bench to bedside: The potential of current treatment beyond RAAS blockade and the horizon of future therapies 

      Gross, O.; Perin, L.; Constantinou-Deltas, Constantinos D. (2014)
      The hereditary type IV collagen disease Alport syndrome (AS) always leads to end-stage renal failure. Yesterday, for the past 90 years, this course was described as 'inevitable'. Today, RAAS blockade has changed the ...

    • Article  

      Altered Phosphorylation, Biosynthesis and Degradation of the 170 kDa Isoform of Topoisomerase II in Amsacrine-Resistant Human Leukemia Cells 

      Ganapathi, R.; Zwelling, L.; Constantinou, Andreas I.; Ford, J.; Grabowski, D. (1993)
      Resistance to amsacrine in HL-60/AMSA is 50-100 fold compared to the parental HL-60/S cells. Synthesis and phosphorylation of topoisomerase II (TOPO II) were 2-3 fold lower in HL-60/AMSA compared to HL-60/S cells metabolically ...

    • Article  

      AM-FM texture segmentation in electron microscopic muscle imaging 

      Pattichis, Marios S.; Pattichis, Constantinos S.; Avraam, Maria; Bovik, Alan Conrad; Kyriacou, Kyriacos C. (2000)
      This paper describes the application of an amplitude modulation-frequency modulation (AM-FM) image representation in segmenting electron micrographs of skeletal muscle for the recognition of: 1) normal sarcomere ultrastructural ...

    • Article  

      Analysis of expired air of fasting male monks at Mount Athos 

      Statheropoulos, Miltiades K.; Agapiou, Agapios; Georgiadou, A. (2006)
      Expired air chemical analysis is investigated as a search and locate method for the early detection of entrapped people under the ruins of collapsed buildings after an earthquake. Fasting individuals were examined as a ...

    • Article  

      Analysis of published PKD1 gene sequence variants [3] 

      Gout, A. M.; Ravine, D.; Harris, Peter C.; Rossetti, S.; Peters, D.; Breuning, M.; Henske, E. P.; Koizumi, A.; Inoue, S.; Shimizu, Y.; Thongnoppakhun, W.; Yenchitsomanus, P. -T; Constantinou-Deltas, Constantinos D.; Sandford, R.; Torra, R.; Turco, A. E.; Jeffery, S.; Fontes, M.; Somlo, Stefan; Furu, L. M.; Smulders, Y. M.; Mercier, B.; Ferec, C.; Burtey, S.; Pei, Y.; Kalaydjieva, L.; Bogdanova, N.; McCluskey, M.; Geon, L. J.; Wouters, C. H.; Reiterova, J.; Stekrová, J.; San Millan, J. L.; Aguiari, G.; Senno, L. D. (2007)

    • Article  

      Analysis of volatile organic compounds released from the decay of surrogate human models simulating victims of collapsed buildings by thermal desorption-comprehensive two-dimensional gas chromatography-time of flight mass spectrometry 

      Agapiou, Agapios; Zorba, Eleni; Mikedi, Katerina; McGregor, L.; Spiliopoulou, C.; Statheropoulos, Miltiades K. (2015)
      Field experiments were devised to mimic the entrapment conditions under the rubble of collapsed buildings aiming to investigate the evolution of volatile organic compounds (VOCs) during the early dead body decomposition ...

    • Article  

      Application of ion mobility spectrometry for the detection of human urine 

      Rudnicka, J.; Mochalski, Paweł; Agapiou, Agapios; Statheropoulos, Miltiades K.; Amann, Anton; Buszewski, B. (2010)
      The aim of the present study was to evaluate the suitability of ion mobility spectrometry (IMS) for the detection of human urine as an indication of human presence during urban search and rescue operations in collapsed ...

    • Article  

      Architectural insight into inovirus-associated vectors (IAVs) and development of IAV-based vaccines inducing humoral and cellular responses: Implications in HIV-1 vaccines 

      Hassapis, K. A.; Stylianou, Dora C.; Kostrikis, Leontios G. (2014)
      Inovirus-associated vectors (IAVs) are engineered, non-lytic, filamentous bacteriophages that are assembled primarily from thousands of copies of the major coat protein gp8 and just five copies of each of the four minor ...

    • Article  

      Assessment of the risk factors of coronary heart events based on data mining with decision trees 

      Karaolis, Minas A.; Moutiris, Joseph Antoniou; Hadjipanayi, Demetra; Pattichis, Constantinos S. (2010)
      Coronary heart disease (CHD) is one of the major causes of disability in adults as well as one of the main causes of death in the developed countries. Although significant progress has been made in the diagnosis and treatment ...

    • Article  

      Association rule analysis for the assessment of the risk of coronary heart events. 

      Karaolis, Minas A.; Moutiris, Joseph Antoniou; Papaconstantinou, L.; Pattichis, Constantinos S. (2009)
      Although significant progress has been made in the diagnosis and treatment of coronary heart disease (CHD), further investigation is still needed. The objective of this study was to develop a data mining system using ...

    • Article  

      Atherosclerotic plaque ultrasound video encoding, wireless transmission, and quality assessment using H.264 

      Panayides, Andreas S.; Pattichis, Marios S.; Pattichis, Constantinos S.; Loizou, Christos P.; Pantzaris, Marios C.; Pitsillides, Andreas (2011)
      We propose a unifying framework for efficient encoding, transmission, and quality assessment of atherosclerotic plaque ultrasound video. The approach is based on a spatially varying encoding scheme, where video-slice ...

    • Article  

      Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIα 

      Aoyama, M.; Grabowski, D. R.; Dubyak, G. R.; Constantinou, Andreas I.; Rybicki, L. A.; Bukowski, R. M.; Ganapathi, M. K.; Hickson, I. D.; Ganapathi, R. (1998)
      Topoisomerase II (topo II), an essential enzyme for cell viability, is also the target for clinically important anti-neoplastic agents that stimulate topo II-mediated DNA scission. The role of alterations in topo IIα ...

    • Article  

      Authors' reply 

      Constantinou-Deltas, Constantinos D.; Voskarides, Konstantinos (2010)

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