Browsing by Subject "hydrophobicity"

Article

Covalent amphiphilic polymer networks

Patrickios, Costas S.; Georgiou, Theoni K. (2003)

The recent literature on chemically cross-linked amphiphilic polymer networks is reviewed. The main subjects covered are network synthesis, characterization, modeling and applications. Special mention is made to more modern ...

Article

Microphase separation under constraints: A molecular thermodynamic theory for polyelectrolytic amphiphilic model networks in water

Georgiou, Theoni K.; Vamvakaki, Maria; Patrickios, Costas S. (2004)

The aqueous aggregation behavior of covalent model networks comprising amphiphilic ABA triblock copolymers with hydrophilic ionic mid-blocks and hydrophobic non-ionic end-blocks was studied by formulating a molecular ...

Article

Molecular Dynamics in Drug Design: New Generations of Compstatin Analogs

Tamamis, Phanourios; López de Victoria, A.; Gorham, R. D.; Bellows-Peterson, M. L.; Pierou, P.; Floudas, C. A.; Morikis, D.; Archontis, Georgios Z. (2012)

We report the computational and rational design of new generations of potential peptide-based inhibitors of the complement protein C3 from the compstatin family. The binding efficacy of the peptides is tested by extensive ...

Article

New compstatin peptides containing n-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics

Gorham, R. D.; Forest, D. L.; Khoury, G. A.; Smadbeck, J.; Beecher, C. N.; Healy, E. D.; Tamamis, Phanourios; Archontis, Georgios Z.; Larive, C. K.; Floudas, C. A.; Radeke, M. J.; Johnson, L. V.; Morikis, D. (2015)

Compstatin peptides are complement inhibitors that bind and inhibit cleavage of complement C3. Peptide binding is enhanced by hydrophobic interactions

Article

Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures

Gorham, R. D.; Forest, D. L.; Tamamis, Phanourios; López de Victoria, A.; Kraszni, M.; Kieslich, C. A.; Banna, C. D.; Bellows-Peterson, M. L.; Larive, C. K.; Floudas, C. A.; Archontis, Georgios Z.; Johnson, L. V.; Morikis, D. (2013)

We have used a novel human retinal pigmented epithelial (RPE) cell-based model that mimics drusen biogenesis and the pathobiology of age-related macular degeneration to evaluate the efficacy of newly designed peptide ...

Article

Solubilization and stabilization of carotenoids using micelles: Delivery of lycopene to cells in culture

Xu, X.; Wang, Y.; Constantinou, Andreas I.; Stacewicz-Sapuntzakis, M.; Bowen, P. E.; Van Breemen, R. B. (1999)

The use of the organic cosolvents tetrahydrofuran and dimethylsulfoxide was found to be unsuitable for prostate tumor cell cultures because of solvent cytotoxicity and the poor solubility and instability of lycopene. For ...

Article

Spectral density ratio based clustering methods for the binary segmentation of protein sequences: A comparative study

Ioannou, Androulla; Fokianos, Konstantinos; Promponas, Vasilis J. (2010)

We compare several spectral domain based clustering methods for partitioning protein sequence data. The main instrument for this exercise is the spectral density ratio model, which specifies that the logarithmic ratio of ...

Article

Synthesis, characterization, and evaluation as transfection reagents of ampholytic star copolymers: Effect of star architecture

Georgiou, Theoni K.; Phylactou, Leonidas A.; Patrickios, Costas S. (2006)

Five star polymers based on the positively ionizable hydrophilic 2-(dimethylamino)ethyl methacrylate (DMAEMA) and the hydrophobic but hydrolyzable tetrahydropyranyl methacrylate (THPMA) were prepared by group-transfer ...