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Browsing by Subject "messenger RNA"

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    • Article  

      Epistatic Role of the MYH9/APOL1 Region on Familial Hematuria Genes 

      Voskarides, Konstantinos; Demosthenous, Panayiota; Papazachariou, Louiza; Arsali, Maria; Athanasiou, Yiannis; Zavros, Michalis; Stylianou, Konstantinos G.; Xydakis, D.; Daphnis, Eugenios K.; Gale, D. P.; Maxwell, P. H.; Elia, Avraam; Pattaro, C.; Pierides, Alkis M.; Constantinou-Deltas, Constantinos D. (2013)
      Familial hematuria (FH) is explained by at least four different genes (see below). About 50% of patients develop late proteinuria and chronic kidney disease (CKD). We hypothesized that MYH9/APOL1, two closely linked genes ...

    • Article  

      Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms 

      Liu, J.; Burdette, J. E.; Xu, H.; Gu, C.; Van Breemen, R. B.; Bhat, K. P. L.; Booth, N.; Constantinou, Andreas I.; Pezzuto, J. M.; Fong, H. H. S.; Farnsworth, N. R.; Bolton, J. L. (2001)
      Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus ...

    • Article  

      High-resolution whole-mount in situ hybridization using quantum dot nanocrystals 

      Ioannou, Androulla; Eleftheriou, Iro; Lubatti, Andrea; Charalambous, Anna; Skourides, Paris A. (2012)
      The photostability and narrow emission spectra of nanometer-scale semiconductor crystallites (QDs) make them desirable candidates for whole-mount fluorescent in situ hybridization to detect mRNA transcripts in morphologically ...

    • Article  

      Identification of Ras suppressor-1 (RSU-1) as a potential breast cancer metastasis biomarker using a three-dimensional in vitro approach 

      Gkretsi, V.; Stylianou, A.; Louca, M.; Stylianopoulos, T. (2017)
      Breast cancer (BC) is the most common malignant disease in women, with most patients dying from metastasis to distant organs, making discovery of novel metastasis biomarkers and therapeutic targets imperative. Extracellular ...

    • Article  

      Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy 

      Kirmizis, Antonis; Bartley, S. M.; Farnham, P. J. (2003)
      We have previously identified SU(Z)12 as an E2F target gene. Because many E2F target genes encode proteins that are critical for the control of cell proliferation, we have further characterized the regulation and expression ...

    • Article  

      In vivo, site-specific, covalent conjugation of quantum dots to proteins via split-intein splicing 

      Charalambous, Anna; Andreou, Maria I.; Antoniades, Ioanna; Christodoulou, Neophytos; Skourides, Paris A. (2012)
      The ability to target proteins with nanostructures and/or nanodevices in vivo is important for understanding and controlling their biological function. Quantum dots (QDs) serve as an ideal model nanostructure due to their ...

    • Article  

      Making the Connection: Ciliary Adhesion Complexes Anchor Basal Bodies to the Actin Cytoskeleton 

      Antoniades, Ioanna; Stylianou, Panayiota; Skourides, Paris A. (2014)
      Cilia have been associated with diverse developmental and physiological processes, and defects in cilia underlie a number of genetic conditions. Several lines of evidence support a critical role of the actin cytoskeleton ...

    • Article  

      MicroRNAs: A newly described class of encoded molecules that play a role in health and disease 

      Felekkis, Kyriacos N.; Touvana, Evi; Stefanou, Charalambos; Constantinou-Deltas, Constantinos D. (2010)
      14(4): 236-240.

    • Article  

      Regulation of Lactate Dehydrogenase Gene Expression by AMP‐dependent Protein Kinase Subunits 

      JUNGMANN, R. A.; Constantinou, Andreas I.; SQUINTO, S. P.; KWAST‐WELFELD, J.; SCHWEPPE, J. S. (1986)

    • Article  

      Regulation of retinoid X receptor-γ gene transcript levels in rat heart cells 

      Georgiades, Pantelis; Brickell, P. M. (1998)
      Retinoid X receptor-γ (RXRγ) is a transcription factor that mediates retinoid signalling and is expressed in rat heart during adult life. However, its expression in embryonic and neonatal heart has not been investigated ...

    • Article  

      Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells 

      Tonetti, D. A.; Rubenstein, R.; DeLeon, M.; Zhao, H.; Pappas, S. G.; Bentrem, D. J.; Chen, B.; Constantinou, Andreas I.; Jordan, V. C. (2003)
      We previously reported stable transfection of estrogen receptor alpha (ERα) into the ER-negative MDA-MB-231 cells (S30) as a tool to examine the mechanism of action of estrogen and antiestrogens [J. Natl. Cancer Inst. 84 ...

    • Article  

      Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy 

      Lewin, S. R.; Vesanen, M.; Kostrikis, Leontios G.; Hurley, A.; Duran, M.; Zhang, L.; Ho, David D.; Markowitz, M.; Gibson, U. E.; Heid, C. A. (1999)
      We have designed a novel, precise, and sensitive assay to measure unspliced (US) human immunodeficiency virus type 1 (HIV-1) mRNA in peripheral blood mononuclear cells of HIV-1-infected individuals by using real-time PCR ...

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