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Browsing by Subject "nerve cell"

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    • Article  

      Behavioral plasticity through the modulation of switch neurons 

      Vassiliades, Vassilis; Christodoulou, Chris C. (2016)
      A central question in artificial intelligence is how to design agents capable of switching between different behaviors in response to environmental changes. Taking inspiration from neuroscience, we address this problem by ...

    • Article  

      A Biophysical Model of Endocannabinoid-Mediated Short Term Depression in Hippocampal Inhibition 

      Zachariou, Margarita; Alexander, S. P. H.; Coombes, S.; Christodoulou, Chris C. (2013)
      Memories are believed to be represented in the synaptic pathways of vastly interconnected networks of neurons. The plasticity of synapses, that is, their strengthening and weakening depending on neuronal activity, is ...

    • Article  

      Distinguishing the causes of firing with themembrane potential slope 

      Koutsou, Achilleas; Christodoulou, Chris C.; Bugmann, G.; Kanev, J. (2012)
      In this letter, we aim to measure the relative contribution of coincidence detection and temporal integration to the firing of spikes of a simple neuron model. To this end, we develop a method to infer the degree of synchrony ...

    • Article  

      Does high firing irregularity enhance learning? 

      Christodoulou, Chris C.; Cleanthous, A. (2011)
      In this note, we demonstrate that the high firing irregularity produced by the leaky integrate-and-fire neuron with the partial somatic reset mechanism, which has been shown to be the most likely candidate to reflect the ...

    • Article  

      Editorial 

      Lucas, P.; Rospars, J. -P; Christodoulou, Chris C. (2015)

    • Article  

      Introduction to the special issue on " Advances in Biomedical Engineering and Computing: The MEDICON Conference Case" selected papers from MEDICON 2010 

      Bamidis, Panagiotis D.; Bliznakova, K.; Pallikarakis, N.; Pattichis, Constantinos S. (2012)

    • Article  

      KIF2β, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation 

      Santama, Niovi; Krijnse-Ĺocker, J.; Griffiths, G.; Noda, Y.; Hirokawa, N.; Dotti, C. G. (1998)
      Lysosomes concentrate juxtanuclearly in the region around the microtubule-organizing center by interaction with microtubules. Different experimental and physiological conditions can induce these organelles to move to the ...

    • Article  

      Learning optimisation by high firing irregularity 

      Cleanthous, A.; Christodoulou, Chris C. (2012)
      In a network of leaky integrate-and-fire (LIF) neurons, we investigate the functional role of irregular spiking at high rates. Irregular spiking is produced by either employing the partial somatic reset mechanism on every ...

    • Article  

      Measuring input synchrony in the Ornstein-Uhlenbeck neuronal model through input parameter estimation 

      Koutsou, Achilleas; Kanev, J.; Christodoulou, Chris C. (2013)
      We present a method of estimating the input parameters and through them, the input synchrony, of a stochastic leaky integrate-and-fire neuronal model based on the Ornstein-Uhlenbeck process when it is driven by time-dependent ...

    • Article  

      Multiagent reinforcement learning: Spiking and nonspiking agents in the Iterated Prisoner's Dilemma 

      Vassiliades, Vassilis; Cleanthous, A.; Christodoulou, Chris C. (2011)
      This paper investigates multiagent reinforcement learning (MARL) in a general-sum game where the payoffs' structure is such that the agents are required to exploit each other in a way that benefits all agents. The contradictory ...

    • Article  

      Near Poisson-type firing produced by concurrent excitation and inhibition 

      Christodoulou, Chris C.; Bugmann, G. (2000)
      The effect of inhibition on the firing variability is examined in this paper using the biologically-inspired temporal noisy-leaky integrator (TNLI) neuron model. The TNLI incorporates hyperpolarising inhibition with negative ...

    • Article  

      Overexpression of the m4 and mα genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition 

      Apidianakis, Yiorgos; Nagel, A. C.; Chalkiadaki, Angeliki; Preiss, A.; Delidakis, Christos (1999)
      Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and ...

    • Article  

      A spiking neuron model: Applications and learning 

      Christodoulou, Chris C.; Bugmann, G.; Clarkson, T. G. (2002)
      This paper presents a biologically inspired, hardware-realisable spiking neuron model, which we call the Temporal Noisy-Leaky Integrator (TNLI). The dynamic applications of the model as well as its applications in Computational ...

    • Article  

      Synchrony measure for a neuron driven by excitatory and inhibitory inputs and its adaptation to experimentally-recorded data 

      Zavou, C.; Kkoushi, A.; Koutsou, Achilleas; Christodoulou, Chris C. (2017)
      The aim of the current work is twofold: firstly to adapt an existing method measuring the input synchrony of a neuron driven only by excitatory inputs in such a way so as to account for inhibitory inputs as well and secondly ...

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