Browsing by Subject "pancreas cancer"

Now showing items 1-4 of 4

    • Article  

      Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels 

      Chauhan, V. P.; Martin, J. D.; Liu, H.; Lacorre, D. A.; Jain, S. R.; Kozin, S. V.; Stylianopoulos, T.; Mousa, A. S.; Han, X.; Adstamongkonkul, P.; Popovic, Z.; Huang, P.; Bawendi, M. G.; Boucher, Y.; Jain, R. K. (2013)
      Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...
    • Article  

      Remodeling components of the tumor microenvironment to enhance cancer therapy 

      Gkretsi, V.; Stylianou, A.; Papageorgis, P.; Polydorou, C.; Stylianopoulos, T. (2015)
      Solid tumor pathophysiology is characterized by an abnormal microenvironment that guides tumor progression and poses barriers to the efficacy of cancer therapies. Most common among tumor types are abnormalities in the ...
    • Article  

      The role of mechanical forces in tumor growth and therapy 

      Jain, R. K.; Martin, J. D.; Stylianopoulos, T. (2014)
      Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...
    • Article  

      Targeting Inflammation to Improve Tumor Drug Delivery 

      Gkretsi, V.; Zacharia, L. C.; Stylianopoulos, T. (2017)
      Inefficient delivery of drugs is a main cause of chemotherapy failure in hypoperfused tumors. To enhance perfusion and drug delivery in these tumors, two strategies have been developed: vascular normalization, aiming at ...