Browsing by Subject "small interfering RNA"
Now showing items 1-6 of 6
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Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway
(2016)Protein N-terminal acetylation is an abundant post-translational modification in eukaryotes implicated in various fundamental cellular and biochemical processes. This modification is catalysed by evolutionarily conserved ...
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Hydrophilic cationic star homopolymers based on a novel diethanol-n-methylamine dimethacrylate cross-linker for sirna transfection: Synthesis, characterization, and evaluation
(2011)Four cationic hydrophilic star homopolymers based on the novel hydrophilic, positively ionizable cross-linker bis(methacryloyloxyethyl)methylamine (BMEMA) were synthesized using sequential group transfer polymerization ...
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Identification of Ras suppressor-1 (RSU-1) as a potential breast cancer metastasis biomarker using a three-dimensional in vitro approach
(2017)Breast cancer (BC) is the most common malignant disease in women, with most patients dying from metastasis to distant organs, making discovery of novel metastasis biomarkers and therapeutic targets imperative. Extracellular ...
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RNA intereference: A powerful laboratory tool and its therapeutic implications
(2006)Ever since RNA intereference (RNAi) was discovered in the early 1990s, a number of scientists from the academic and biotechnology world have continued to view it as the revolutionary discovery of the century. Unequivocally, ...
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Article
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27
(2004)Polycomb group (PcG) complexes 2 and 3 are involved in transcriptional silencing. These complexes contain a histone lysine methyltransferase (HKMT) activity that targets different lysine residues on histones H1 or H3 in ...
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Article
Trophoblast-specific gene manipulation using lentivirus-based vectors
(2007)The trophoblast layers of the mammalian placenta carry out many complex functions required to pattern the developing embryo and maintain its growth and survival in the uterine environment. Genetic disruption of many gene ...