Browsing by Subject "static electricity"

Article

Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model

Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (2013)

Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...

Article

Chaotropic salts interacting with soft matter: Beyond the lyotropic series

Leontidis, Epameinondas (2016)

The effects of the chaotropic ions of the Hofmeister series on many systems and phenomena are typically quite pronounced. What happens, however, when one uses chaotropic ions beyond SCN−, ClO4 −, or guanidinium, which are ...

Article

Equilibrium in soft-matter systems under the influence of competing forces

Zemb, T.; Leontidis, Epameinondas (2013)

Article

Kinetics, in silico docking, molecular dynamics, and MM-GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP-binding site inhibitors: The role of water molecules examined

Bischler, N.; Hayes, Joseph M.; Skamnaki, Vicky T.; Archontis, Georgios Z.; Lamprakis, Christos; Sarrou, Josephine; Skaltsounis, Alexios Leandros; Zographos, Spyros E.; Oikonomakos, Nikos G. (2011)

With an aim toward glycogenolysis control in Type 2 diabetes, we have investigated via kinetic experiments and computation the potential of indirubin (IC 50 > 50 μM), indirubin-3'-oxime (IC 50 = 144 nM), KT5720 (K i = 18.4 ...

Article

Long-range charge transport in single G-quadruplex DNA molecules

Livshits, G. I.; Stern, A.; Rotem, D.; Borovok, N.; Eidelshtein, G.; Migliore, A.; Penzo, E.; Wind, S. J.; Di Felice, R.; Skourtis, Spiros S.; Cuevas, J. C.; Gurevich, L.; Kotlyar, A. B.; Porath, D. (2014)

DNA and DNA-based polymers are of interest in molecular electronics because of their versatile and programmable structures. However, transport measurements have produced a range of seemingly contradictory results due to ...

Article

Particle deposition in a realistic geometry of the human conducting airways: Effects of inlet velocity profile, inhalation flowrate and electrostatic charge

Koullapis, P. G.; Kassinos, Stavros C.; Bivolarova, M. P.; Melikov, A. K. (2016)

Understanding the multitude of factors that control pulmonary deposition is important in assessing the therapeutic or toxic effects of inhaled particles. The use of increasingly sophisticated in silico models has improved ...

Article

Physical constraints on charge transport through bacterial nanowires

Polizzi, N. F.; Skourtis, Spiros S.; Beratan, David N. (2012)

Extracellular appendages of the dissimilatory metal-reducing bacterium Shewanella oneidensis MR-1 were recently shown to sustain currents of 10 10 electrons per second over distances of 0.5 microns [El-Naggar et al., Proc. ...

Article

Regional aerosol deposition in the human airways: The SimInhale benchmark case and a critical assessment of in silico methods

Koullapis, P.; Kassinos, Stavros C.; Muela, J.; Perez-Segarra, C.; Rigola, J.; Lehmkuhl, O.; Cui, Y.; Sommerfeld, M.; Elcner, J.; Jicha, M.; Saveljic, I.; Filipovic, N.; Lizal, F.; Nicolaou, L. (2018)

Regional deposition effects are important in the pulmonary delivery of drugs intended for the topical treatment of respiratory ailments. They also play a critical role in the systemic delivery of drugs with limited lung ...