Browsing by Subject "transgene"
Now showing items 1-5 of 5
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Article
Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes
(2016)The insufficient ability of specialized cells such as neurons, cardiac myocytes, and epidermal cells to regenerate after tissue damage poses a great challenge to treat devastating injuries and ailments. Recent studies ...
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Article
Drosophila melanogaster as a model for human intestinal infection and pathology
(2011)Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this model is well suited for the study of intestinal stem cell physiology during aging, stress and infection. Despite the physiological ...
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Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes
(2008)A major obstacle to creating precisely expressed transgenes lies in the epigenetic effects of the host chromatin that surrounds them. Here we present a strategy to overcome this problem, employing a Gal4-inducible luciferase ...
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Article
Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch
(2001)Groucho (Gro) is the founding member of a family of transcriptional co-repressors that are recruited by a number of different transcription factors. Drosophila has a single gro gene, whose loss of function affects processes ...
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Article
Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer
(2007)Infection with high-risk human papillomaviruses (HPV) and in particular the expression of the viral proteins E6 and E7 have been associated with the etiology of a subset of head and neck squamous cell cancer (HNSCC). ...