Browsing by Subject "tumor growth"

Article

Beneficial effects of a vanadium complex with cysteine, administered at low doses on benzo(α) pyrene-induced leiomyosarcomas in wistar rats

Liasko, Roman; Kabanos, Themistoklis A.; Karkabounas, Spyridon Ch; Malamas, Michael Ph; Tasiopoulos, Anastasios J.; Stefanou, Dimitrios G.; Collery, P.; Evangelou, Angelos M. (1998)

Background: Vanadium is a potent environmental and body metal, possessing remarkable antitumor and antidiabetic properties. Vanadium salts and complexes have been widely investigated for their anticarcinogenic properties ...

Article

Biphasic modeling of brain tumor biomechanics and response to radiation treatment

Angeli, S.; Stylianopoulos, T. (2016)

Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical ...

Article

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Jain, S. R.; Diop-Frimpong, B.; Bardeesy, N.; Smith, B. L.; Ferrone, C. R.; Hornicek, F. J.; Boucher, Y.; Munn, L. L.; Jain, R. K. (2012)

The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...

Article

Coevolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse

Stylianopoulos, T.; Martin, J. D.; Snuderl, M.; Mpekris, F.; Jain, S. R.; Jain, R. K. (2013)

The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is ...

Article

Defining the role of solid stress and matrix stiffness in cancer cell proliferation and metastasis

Kalli, M.; Stylianopoulos, T. (2018)

Solid tumors are characterized by an abnormal stroma that contributes to the development of biomechanical abnormalities in the tumor microenvironment. In particular, these abnormalities include an increase in matrix stiffness ...

Article

Model-based tumor growth dynamics and therapy response in a mouse model of de novo carcinogenesis

Loizides, Constantinos A.; Iacovides, D.; Hadjiandreou, M. M.; Rizki, G.; Achilleos, Achilleas P.; Strati, K.; Mitsis, Georgios D. (2015)

Tumorigenesis is a complex, multistep process that depends on numerous alterations within the cell and contribution from the surrounding stroma. The ability to model macroscopic tumor evolution with high fidelity may ...

Article

Multiscale biphasic modelling of peritumoural collagen microstructure: The effect of tumour growth on permeability and fluid flow

Wijeratne, P. A.; Hipwell, J. H.; Hawkes, D. J.; Stylianopoulos, T.; Vavourakis, V. (2017)

We present an in-silico model of avascular poroelastic tumour growth coupled with a multiscale biphasic description of the tumour–host environment. The model is specified to in-vitro data, facilitating biophysically realistic ...

Article

Multiscale modelling of solid tumour growth: the effect of collagen micromechanics

Wijeratne, P. A.; Vavourakis, V.; Hipwell, J. H.; Voutouri, C.; Papageorgis, P.; Stylianopoulos, T.; Evans, A.; Hawkes, D. J. (2016)

Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...

Article

Remodeling components of the tumor microenvironment to enhance cancer therapy

Gkretsi, V.; Stylianou, A.; Papageorgis, P.; Polydorou, C.; Stylianopoulos, T. (2015)

Solid tumor pathophysiology is characterized by an abnormal microenvironment that guides tumor progression and poses barriers to the efficacy of cancer therapies. Most common among tumor types are abnormalities in the ...

Article

Remodeling of extracellular matrix due to solid stress accumulation during tumor growth

Pirentis, A. P.; Polydorou, C.; Papageorgis, P.; Voutouri, C.; Mpekris, F.; Stylianopoulos, T. (2015)

Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive ...

Article

Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors

Voutouri, C.; Mpekris, F.; Papageorgis, P.; Odysseos, A. D.; Stylianopoulos, T. (2014)

Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibits their proliferation rate, induces apoptosis and enhances their invasive and metastatic potential. Additionally, compression ...

Article

The role of mechanical forces in tumor growth and therapy

Jain, R. K.; Martin, J. D.; Stylianopoulos, T. (2014)

Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...

Article

Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review)

Papageorgis, P.; Stylianopoulos, T. (2015)

Deregulation of cell signaling homeostasis is a predominant feature of cancer initiation and progression. Transforming growth factor β (TGFβ) is a pleiotropic cytokine, which regulates numerous biological processes of ...

Article

Role of vascular normalization in benefit from metronomic chemotherapy

Mpekris, F.; Baish, J. W.; Stylianopoulos, T.; Jain, R. K. (2017)

Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in ...

Article

The Solid Mechanics of Cancer and Strategies for Improved Therapy

Stylianopoulos, T. (2017)

Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...

Article

Soy protein isolate prevents chemically-induced rat mammary tumors

Constantinou, Andreas I.; Morgan Lucas, L.; Lantvit, D.; Hawthorne, M.; Xu, X.; Chu, W. N.; Jeffery, E. H.; Christov, K.; Van Breemen, R. B.; Pezzuto, J. M. (2002)

purified daidzein at 200 mg/kg diet

Article

Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery

Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (2015)

Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...

Article

A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth

Vavourakis, V.; Wijeratne, P. A.; Shipley, R.; Loizidou, M.; Stylianopoulos, T.; Hawkes, D. J. (2017)

Vascularisation is a key feature of cancer growth, invasion and metastasis. To better understand the governing biophysical processes and their relative importance, it is instructive to develop physiologically representative ...