Browsing by Subject "unclassified drug"

Article

Broom-like and flower-like heterostructures of silver molybdate through pH controlled self assembly

Singh, D. P.; Sirota, B.; Talpatra, S.; Kohli, P.; Rebholz, Claus; Aouadi, S. M. (2012)

Silver molybdate microrods are selfassembled into micron sized, broom-like and flowerlike structures. Our investigations indicate that through a simple hydrothermal process, large scale production of such structure is ...

Article

Controlled synthesis of homopolymers and block copolymers based on 2-(acetoacetoxy)ethyl methacrylate via RAFT radical polymerisation

Krasia-Christoforou, T.; Soula, R.; Börner, H. G.; Schlaad, H. (2003)

Reversible addition-fragmentation chain transfer (RAFT) radical polymerisation enables to synthesise well-defined homopolymers and block copolymers based on 2-(acetoacetoxy)ethyl methacrylate, which are capable to strongly ...

Article

Delivering nanomedicine to solid tumors

Jain, R. K.; Stylianopoulos, T. (2010)

Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using nanoparticles to treat ...

Article

Design considerations for nanotherapeutics in oncology

Stylianopoulos, T.; Jain, R. K. (2015)

Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing the adverse effects of chemotherapeutic agents, but improvements in overall survival are modest. This is in large part due to the ...

Article

Fabrication, characterization, and evaluation in drug release properties of magnetoactive poly(ethylene oxide)-poly(l -lactide) electrospun membranes

Savva, I.; Odysseos, A. D.; Evaggelou, L.; Marinica, O.; Vasile, E.; Vekas, L.; Sarigiannis, Y.; Krasia-Christoforou, T. (2013)

The fabrication of electrospun magnetoactive fibrous nanocomposite membranes based on the water-soluble and biocompatible poly(ethylene oxide) (PEO), the biocompatible and biodegradable poly(l-lactide) (PLLA) and preformed ...

Article

Formation of oligotriazoles catalysed by cucurbituril

Krasia-Christoforou, T.; Steinke, J. H. G. (2002)

The catalytic activity of cucurbituril in 1,3-dipolar cycloadditions has been applied to the synthesis of oligotriazoles.

Article

Identification of Ras suppressor-1 (RSU-1) as a potential breast cancer metastasis biomarker using a three-dimensional in vitro approach

Gkretsi, V.; Stylianou, A.; Louca, M.; Stylianopoulos, T. (2017)

Breast cancer (BC) is the most common malignant disease in women, with most patients dying from metastasis to distant organs, making discovery of novel metastasis biomarkers and therapeutic targets imperative. Extracellular ...

Article

Manganese citrate chemistry: Syntheses, spectroscopic studies, and structural characterizations of novel mononuclear, water-soluble manganese citrate complexes

Matzapetakis, M.; Karligiano, N.; Bino, A.; Dakanali, M.; Raptopoulou, C. P.; Tangoulis, V.; Terzis, A.; Giapintzakis, John; Salifoglou, A. (2000)

The first two mononuclear manganese citrate complexes, (NH4)4[Mn(II)(C6H5O7)2] (1) and (NH4)5[Mn(III)(C6H4O7)2]·2H2O (2) were synthesized in aqueous solutions near physiological pH values. They were isolated in their pure ...

Article

Near-monodisperse sodium polymethacrylates: Characterization by linear salt gradient anion-exchange chromatography

Freydank, A.; Krasia-Christoforou, T.; Tiddy, G. J. T.; Patrickios, C. S. (2000)

A family of six near-monodisperse homopolymers of sodium methacrylate (Mn = 1100, 3200, 5500, 7200, 14100, and 21000) is characterized by linear salt gradient anion-exchange chromatography. Although the retention times ...

Article

Pirfenidone normalizes the tumor microenvironment to improve chemotherapy

Polydorou, C.; Mpekris, F.; Papageorgis, P.; Voutouri, C.; Stylianopoulos, T. (2017)

Normalization of the tumor microenvironment by selectively targeting components of the tumor extracellular matrix has been recently proposed to have the potential to decompress tumor blood vessels, increase vessel perfusion ...

Article

Superhelices of poly[2-(acetoacetoxy)ethyl methacrylate]

Schlaad, H.; Krasia-Christoforou, T.; Antonietti, M. (2004)

Poly[2-(acetoacetoxy) ethyl methacrylate] (PAEMA) homopolymers were found to self-assemble into hierarchical superstructures, that is, double-stranded helical tubes of either screw sense (scanning force microscopy). Both ...

Article

Superparamagnetic hybrid micelles, based on iron oxide nanoparticles and well-defined diblock copolymers possessing β-ketoester functionalities

Papaphilippou, P.; Loizou, L.; Popa, N. C.; Han, A.; Vekas, L.; Odysseos, A.; Krasia-Christoforou, T. (2009)

The quality of surface coating of magnetic nanoparticles destined as nanoprobes in clinical applications is of utmost significance for their colloidal stability and biocompatibility. A novel approach for the fabrication ...

Article

Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPA)

Gkretsi, V.; Stylianou, A.; Stylianopoulos, T. (2017)

A hallmark of cancer cells is their ability to invade surrounding tissues and form metastases. Cell-extracellular matrix (ECM)-adhesion proteins are crucial in metastasis, connecting tumor ECM with actin cytoskeleton thus ...