Browsing by Subject "vascular tumor"

Now showing items 1-2 of 2

    • Article  

      Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels 

      Chauhan, V. P.; Martin, J. D.; Liu, H.; Lacorre, D. A.; Jain, S. R.; Kozin, S. V.; Stylianopoulos, T.; Mousa, A. S.; Han, X.; Adstamongkonkul, P.; Popovic, Z.; Huang, P.; Bawendi, M. G.; Boucher, Y.; Jain, R. K. (2013)
      Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...
    • Article  

      Role of vascular normalization in benefit from metronomic chemotherapy 

      Mpekris, F.; Baish, J. W.; Stylianopoulos, T.; Jain, R. K. (2017)
      Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in ...