Browsing by Subject "vascular normalization"
Now showing items 1-3 of 3
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Article
Combining two strategies to improve perfusion and drug delivery in solid tumors
(2013)Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a ...
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Article
The role of mechanical forces in tumor growth and therapy
(2014)Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...
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Article
Targeting Inflammation to Improve Tumor Drug Delivery
(2017)Inefficient delivery of drugs is a main cause of chemotherapy failure in hypoperfused tumors. To enhance perfusion and drug delivery in these tumors, two strategies have been developed: vascular normalization, aiming at ...