• Article  

      Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions 

      Schweighardt, B.; Ortiz, G. M.; Grant, R. M.; Wellons, M.; Miralles, G. D.; Kostrikis, Leontios G.; Bartlett, J. A.; Nixon, D. F. (2002)
      We report the emergence of drug-resistant viral mutations in chronically HIV-infected individuals undergoing structured treatment interruptions (STI). The protease mutation M46L and the reverse transcriptase mutations K101E ...
    • Article  

      Emergence of Minor Populations of Human Immunodeficiency Virus Type 1 Carrying the M184V and L90M Mutations in Subjects Undergoing Structured Treatment Interruptions 

      Metzner, K. J.; Bonhoeffer, S.; Fischer, M.; Karanicolas, R.; Allers, K.; Joos, B.; Weber, R.; Hirschel, B.; Kostrikis, Leontios G.; Günthard, H. F. (2003)
      The use of structured treatment interruption (STI) in human immunodeficiency virus (HIV)-infected subjects is currently being studied as an alternative therapeutic strategy for HIV-1. The potential risk for selection of ...
    • Article  

      Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe 

      Moutschen, M.; Frentz, D.; Van de Vijver, D. A. M. C.; Abecasis, A. B.; Albert, Jan; Hamouda, O.; Jørgensen, L. B.; Ku¨cherer, C.; Struck, D.; Schmit, J. -C; Vercauteren, J.; A˚sjo¨, B.; Balotta, Claudia; Beshkov, Danail; Camacho, Ricardo J.; Clotet, B.; Coughlan, S.; Griskevicius, A.; Grossman, Z.; Horban, A.; Kolupajeva, T.; Korn, K.; Kostrikis, Leontios G.; Liitsola, K.; Linka, M.; Nielsen, C.; Otelea, D.; Paraskevis, Dimitrios N.; Paredes, R.; Poljak, M.; Puchhammer-Sto¨ckl, E.; So¨nnerborg, A.; Stanekova, D.; Stanojevic, M.; Van Wijngaerden, E.; Wensing, A. M. J.; Boucher, C. A. B.; Puchhammer-Stockl, E.; Sarcletti, M.; Schmied, B.; Geit, M.; Balluch, G.; Vandamme, A. -M; Vercauteren, J.; Derdelinckx, I.; Sasse, A.; Bogaert, M.; Ceunen, H.; De Roo, A.; De Wit, S.; Echahidi, F.; Fransen, K.; Goffard, J. -C; Goubau, P.; Goudeseune, E.; Yombi, J. -C; Lacor, P.; Liesnard, C.; Pierard, D.; Rens, R.; Schrooten, Y.; Vaira, D.; Vandekerckhove, L. P. R.; Van den Heuvel, A.; Van Der Gucht, B.; Van Ranst, M.; Van Wijngaerden, E.; Vandercam, B.; Vekemans, M.; Verhofstede, C.; Clumeck, N.; Van Laethem, K.; Demetriades, Ioannis; Kousiappa, Ioanna; Demetriou, Victoria L.; Hezka, Johana; Bruckova, M.; Linka, M.; Machala, L.; Nielsen, C.; Jørgensen, L. B.; Gerstoft, J.; Mathiesen, L.; Pedersen, C.; Nielsen, H.; Laursen, A.; Kvinesdal, B.; Salminen, M.; Ristola, M.; Liitsola, K.; Suni, J.; Sutinen, J.; Korn, K.; Ku¨cherer, C.; Berg, T.; Braun, P.; Poggensee, G.; Da¨umer, M.; Eberle, J.; Heiken, H.; Kaiser, R.; Knechten, H.; Mu¨ller, H.; Neifer, S.; Schmidt, B.; Walter, H.; Gunsenheimer-Bartmeyer, B.; Harrer, T.; Paraskevis, Dimitrios N.; Hatzakis, Angelos E.; Magiorkinis, Emmanouil N.; Hatzitheodorou, Eleni; Haida, Catherine; Zavitsanou, Assimina; Magiorkinis, Gkikas; Lazanas, Marios C.; Chini, Maria C.; Magafas, N.; Tsogas, Nickolaos; Paparizos, Vassilios A.; Kourkounti, Sofia; Antoniadou, Anastasia C.; Papadopoulos, Antonios I.; Panagopoulos, Periklis; Poulakou, Garyphallia G.; Sakka, V.; Chryssos, Georgios; Drimis, Stylianos; Gargalianos, Panagiotis; Lelekis, Moyssis I.; Chilomenos, G.; Psichogiou, Mina A.; Daikos, George L.; Panos, George; Haratsis, G.; Kordossis, Theodore; Kontos, Athanasios N.; Koratzanis, Georgios; Theodoridou, Maria C.; Mostrou, Glykeria J.; Spoulou, Vana I.; Coughlan, S.; De Gascun, C.; Byrne, C.; Duffy, M.; Bergin, C.; Reidy, D.; Farrell, G.; Lambert, J.; O'Connor, E.; Rochford, A.; Low, J.; Coakely, P.; O'Dea, S.; Hall, W.; Grossman, Z.; Levi, I.; Chemtob, D.; Balotta, Claudia; Riva, C.; Mussini, C.; Caramma, I.; Capetti, A.; Colombo, M. C.; Rossi, C.; Prati, F.; Tramuto, F.; Vitale, F.; Ciccozzi, M.; Angarano, G.; Rezza, G.; Schmit, J. C.; Struck, D.; Hemmer, R.; Arendt, V.; Staub, T.; Schneider, F.; Roman, F.; Wensing, A. M. J.; Boucher, C. A. B.; van Kessel, A.; van Bentum, P. H. M.; Brinkman, K.; op de Coul, E. L.; van der Ende, M. E.; Hoepelman, I.; van Kasteren, M.; Juttmann, J.; Kuipers, M.; Langebeek, N.; Richter, C.; Santegoets, R.; Schrijnders-Gudde, L.; Schuurman, R.; van de Ven, B. J. M.; A˚sjo¨, B.; Ormaasen, V.; Aavitsland, P.; Horban, A.; Stanczak, J. J.; Stanczak, G. P.; Firlag-Burkacka, E.; Wiercinska-Drapalo, A.; Jablonowska, E.; Malolepsza, E.; Leszczyszyn-Pynka, M.; Szata, W.; Camacho, Ricardo J.; Palma, C.; Borges, F.; Paixa&tild; o, T.; Duque, V.; Araújo, F.; Jevtovic, D.; Salemovic, D.; Stanekova, D.; Habekova, M.; Mokráš, Miloš; Truska, P.; Poljak, M.; Lunar, M.; Babic, Dunja Z.; Tomazic, J.; Vidmar, L.; Vovko, T.; Karner, P.; Clotet, B.; Domingo, P.; Galindo, M. J.; Miralles, C.; del Pozo, M. A.; Ribera, E.; Iribarren, J. A.; Ruiz, L.; de la Torre, J.; Vidal, F.; Garcia, F.; Paredes, R.; Albert, Jan; Heidarian, A.; Aperia-Peipke, K.; Axelsson, M.; Mild, M.; Karlsson, A.; So¨nnerborg, A.; Thalme, A.; Nave´r, L.; Bratt, G.; Karlsson, A.; Blaxhult, A.; Gissle´n, M.; Svennerholm, B.; Bergbrant, I.; Björkman, Per; Sa¨ll, C.; Mellgren, A˚; Lindholm, A.; Kuylenstierna, N.; Montelius, R.; Azimi, F.; Johansson, B.; Carlsson, M.; Johansson, E.; Ljungberg, B.; Ekvall, H.; Strand, A.; Ma¨kitalo, S.; o¨berg, S.; Holmblad, P.; Ho¨fer, M.; Holmberg, H.; Josefson, P.; Ryding, U. (2014)
      Background: One out of ten newly diagnosed patients in Europe was infected with a virus carrying a drug resistant mutation. We analysed the patterns over time for transmitted drug resistance mutations (TDRM) using data ...
    • Article  

      Patterns of transmitted HIV drug resistance in Europe vary by risk group 

      Frentz, D.; Van De Vijver, D.; Abecasis, A. B.; Albert, Jan; Hamouda, O.; Jørgensen, L.; Kücherer, C.; Struck, D.; Schmit, J. -C; Vercauteren, J.; Åsjö, Birgitta; Balotta, Claudia; Bergin, C.; Beshkov, Danail; Camacho, Ricardo J.; Clotet, B.; Griskevicius, A.; Grossman, Z.; Horban, A.; Kolupajeva, T.; Korn, K.; Kostrikis, Leontios G.; Linka, K. L. M.; Nielsen, C.; Otelea, D.; Paraskevis, Dimitrios N.; Paredes, R.; Poljak, M.; Puchhammer-Stöckl, E.; Sönnerborg, A.; Stanekova, D.; Stanojevic, M.; Vandamme, A. -M; Boucher, C.; Wensing, A. (2014)
      Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the ...
    • Article  

      Short communication: Molecular epidemiology of HIV type 1 infection in northern Greece (2009-2010): Evidence of a transmission cluster of HIV Type 1 Subtype A1 drug-resistant strains among men who have sex with men 

      Antoniadou, Zoi Anna; Kousiappa, Ioanna; Skoura, Lemonia G.; Pilalas, Dimitrios; Metallidis, Simeon A.; Nicolaidis, Pavlos; Malisiovas, Nikolaos; Kostrikis, Leontios G. (2014)
      A prospective molecular epidemiology study of HIV-1 infection was conducted in newly diagnosed and antiretroviral-naive patients in Northern Greece between 2009 and 2010 using a predefined enrolling strategy. Phylogenetic ...