Browsing by Subject "T-Lymphocytes"

Now showing items 1-5 of 5

    • Article  

      Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis 

      Van Heemst, J.; Jansen, D. T. S. L.; Polydorides, Savvas; Moustakas, Antonis K.; Bax, M.; Feitsma, A. L.; Bontrop-Elferink, D. G.; Baarse, M.; Van Der Woude, D.; Wolbink, G. -J; Rispens, T.; Koning, F.; De Vries, R. R. P.; Papadopoulos, George K.; Archontis, Georgios Z.; Huizinga, T. W.; Toes, R. E. (2015)
      The HLA locus is the strongest risk factor for anti-citrullinated protein antibody (ACPA) + rheumatoid arthritis (RA). Despite considerable efforts in the last 35 years, this association is poorly understood. Here we ...
    • Article  

      CXCR4 mediates entry and productive infection of syncytia-inducing (x4) hiv-1 strains in primary macrophages 

      Valentin, A.; Trivedi, H.; Lu, W.; Kostrikis, Leontios G.; Pavlakis, G. N. (2000)
      CCR5 and CXCR4 are the main coreceptors for non-syncytia-inducing (NSI) and syncytia-inducing (SI) HIV-1 strains, respectively. NSI HIV-1 isolates do not infect either human lymphoid or monocytoid cell lines, and this ...
    • Article  

      Effect of recent thymic emigrants on progression of HIV-1 disease 

      Hatzakis, Angelos E.; Touloumi, G.; Karanicolas, R.; Karafoulidou, A.; Mandalaki, T.; Anastassopoulou, C. G.; Zhang, L.; Goedert, J. J.; Ho, David D.; Kostrikis, Leontios G. (2000)
      Background. The concentration of T-cell receptor-rearrangement excision DNA circles (TREC) in peripheral-blood T cells is a marker of recent thymic emigrant αβ T cells. We studied the predictive ability of measurements of ...
    • Article  

      Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy 

      Zhang, L.; Lewin, S. R.; Markowitz, M.; Lin, L. -H; Skulsky, E.; Karanicolas, R.; Yuxian, H.; Xia, J.; Tuttleton, S.; Vesanen, M.; Spiegel, H.; Kost, R.; Van Lunzen, J.; Stellbrink, H. -J; Wolinsky, S.; Borkowsky, W.; Palumbo, P.; Kostrikis, Leontios G.; Ho, David D. (1999)
      The role of the thymus in HIV-1 pathogenesis remains unclear. We developed an assay to quantify the number of recent thymic emigrants in blood based on the detection of a major excisional DNA byproduct (termed α1 circle) ...
    • Article  

      Recent thymic emigrants and prognosis in T- and B-cell childhood hematopoietic malignancies 

      Petridou, E.; Klimentopoulou, A. E.; Moustaki, M.; Kostrikis, Leontios G.; Hatzakis, Angelos E.; Trichopoulos, D. (2002)
      The concentration of T-cell receptor rearrangement excision DNA circles (TRECs) in peripheral blood mononuclear cells (PBMCs) is currently known to be a marker of recent thymic emigrants. We evaluated the hypothesis that ...