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Comparing intracellular stability and targeting of sulfobetaine quantum dots with other surface chemistries in live cells
(2012)
The in vivo labeling of intracellular components with quantum dots (QDs) is very limited because of QD aggregation in the cell cytoplasm and/or QD confinement into lysosomal compartments. In order to improve intracellular ...
A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
(2016)
Control of spindle orientation is a fundamental process for embryonic development, morphogenesis and tissue homeostasis, while defects are associated with tumorigenesis and other diseases. Force sensing is one of the ...
Drug delivery innovations for enhancing the anticancer potential of vitamin e isoforms and their derivatives
(2015)
Vitamin E isoforms have been extensively studied for their anticancer properties. Novel drug delivery systems (DDS) that include liposomes, nanoparticles, and micelles are actively being developed to improve Vitamin E ...
FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis
(2014)
Spindle orientation is critical for proper morphogenesis of organs and tissues as well as for the maintenance of tissue morphology. Although significant progress has been made in understanding the mechanisms linking the ...
Selective activation of TNFR1 and NF-ΚB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells
(2016)
Background: Acquired resistance towards apoptosis is a hallmark of cancer. Elimination of cells bearing activated oncogenes or stimulation of tumor suppressor mediators may provide a selection pressure to overcome resistance. ...
Vernonia kotschyana roots: Therapeutic potential via antioxidant activity
(2014)
The roots of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae) are used in Malian traditional medicine in the treatment of gastroduodenal ulcers and gastritis. Since oxidative stress is involved in gastric ulceration, ...
Hemodynamics in stenotic vessels of small diameter under steady state conditions: Effect of viscoelasticity and migration of red blood cells
(2015)
BACKGROUND: In microcirculation, the non-Newtonian behavior of blood and the complexity of the microvessel network are responsible for the high flow resistance and the large reduction of the blood pressure. Red blood cell ...
New compstatin peptides containing n-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics
(2015)
Compstatin peptides are complement inhibitors that bind and inhibit cleavage of complement C3. Peptide binding is enhanced by hydrophobic interactions
Dynamic vapor generator that simulates transient odor emissions of victims entrapped in the voids of collapsed buildings
(2014)
The design, development, and validation of a dynamic vapor generator are presented. The generator simulates human scent (odor) emissions from trapped victims in the voids of collapsed buildings. The validation of the device ...
Application of ion mobility spectrometry for the detection of human urine
(2010)
The aim of the present study was to evaluate the suitability of ion mobility spectrometry (IMS) for the detection of human urine as an indication of human presence during urban search and rescue operations in collapsed ...