dc.contributor.author | Aravantinos, Gerasimos | en |
dc.contributor.author | Fountzilas, George | en |
dc.contributor.author | Kosmidis, Paraskevas A. | en |
dc.contributor.author | Dimopoulos, M. A. | en |
dc.contributor.author | Stathopoulos, G. P. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Bafaloukos, Dimitrios | en |
dc.contributor.author | Papadimitriou, C. | en |
dc.contributor.author | Karpathios, S. | en |
dc.contributor.author | Georgoulias, V. | en |
dc.contributor.author | Papakostas, P. | en |
dc.contributor.author | Kalofonos, H. P. | en |
dc.contributor.author | Grimani, E. | en |
dc.contributor.author | Skarlos, Dimosthenis V. | en |
dc.creator | Aravantinos, Gerasimos | en |
dc.creator | Fountzilas, George | en |
dc.creator | Kosmidis, Paraskevas A. | en |
dc.creator | Dimopoulos, M. A. | en |
dc.creator | Stathopoulos, G. P. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Bafaloukos, Dimitrios | en |
dc.creator | Papadimitriou, C. | en |
dc.creator | Karpathios, S. | en |
dc.creator | Georgoulias, V. | en |
dc.creator | Papakostas, P. | en |
dc.creator | Kalofonos, H. P. | en |
dc.creator | Grimani, E. | en |
dc.creator | Skarlos, Dimosthenis V. | en |
dc.date.accessioned | 2018-06-22T09:52:26Z | |
dc.date.available | 2018-06-22T09:52:26Z | |
dc.date.issued | 2005 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41352 | |
dc.description.abstract | Background: We compared the combination plus Carboplatin plus paclitaxel, which is considered the treatment of choice for initial chemotherapy of advanced ovarian cancer (AOC) with a regimen combining alternating carboplatin and cisplatin plus paclitaxel. The two platinum derivatives have been previously combined as they are not totally cross-resistant and as they share no overlapping toxicities. Patients and methods: Patients with AOC, after the initial cytoreductive surgery were randomized to either 6 courses of paclitaxel at 175 mg/m2 as 3h infusion plus Carboplatin at 7 AUC (Arm A) or Paclitaxel at the same dose plus Carboplatin again at 7 AUC for cycles 1,3,5, while for cycles 2,4,6 Cisplatin at 75 mg/m2 substituted for Carboplatin (Arm B). Results: 247 patients are analyzed. Significant differences were not found, both in terms of PFS (38 vs 39 months, p=0.95) and overall survival (40.6 vs 38.6 months, p=0.79). There was not also difference in 5-year survival rate (35% vs 39%) or 5-year PFS rate (23% vs 28%). Age >60, PS 2, stage IV disease and presence of residual disease were adversely related to the overall survival. Conclusion: Both regimens are well tolerated and effective. Alternating cisplatin with carboplatin does not improve the results compared with the standard combination. © 2005 European Society fr Medical Oncology. | en |
dc.language.iso | eng | en |
dc.source | Annals of Oncology | en |
dc.subject | Article | en |
dc.subject | Antineoplastic agent | en |
dc.subject | Cisplatin | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Cancer patient | en |
dc.subject | Controlled study | en |
dc.subject | Female | en |
dc.subject | Major clinical study | en |
dc.subject | Advanced cancer | en |
dc.subject | Carboplatin | en |
dc.subject | Chemotherapy | en |
dc.subject | Ovarian cancer | en |
dc.subject | Ovarian neoplasms | en |
dc.subject | Ovary cancer | en |
dc.subject | Paclitaxel | en |
dc.subject | Priority journal | en |
dc.subject | Anemia | en |
dc.subject | Antineoplastic combined chemotherapy protocols | en |
dc.subject | Arthralgia | en |
dc.subject | Clinical trial | en |
dc.subject | Controlled clinical trial | en |
dc.subject | Disease-free survival | en |
dc.subject | Drug efficacy | en |
dc.subject | Fatigue | en |
dc.subject | Febrile neutropenia | en |
dc.subject | Infection | en |
dc.subject | Leukopenia | en |
dc.subject | Mucosa inflammation | en |
dc.subject | Multicenter study | en |
dc.subject | Myalgia | en |
dc.subject | Nausea and vomiting | en |
dc.subject | Neurotoxicity | en |
dc.subject | Neutropenia | en |
dc.subject | Ondansetron | en |
dc.subject | Prospective studies | en |
dc.subject | Recombinant granulocyte colony stimulating factor | en |
dc.subject | Thrombocytopenia | en |
dc.subject | Nephrotoxicity | en |
dc.subject | Survival analysis | en |
dc.subject | Alternating cisplatin with carboplatin | en |
dc.subject | Area under the curve | en |
dc.subject | Cancer staging | en |
dc.subject | Cardiotoxicity | en |
dc.subject | Cimetidine | en |
dc.subject | Cytoreductive surgery | en |
dc.subject | Dexamethasone | en |
dc.subject | Dimetindene | en |
dc.subject | Disease free survival | en |
dc.subject | Drug administration | en |
dc.subject | Drug administration schedule | en |
dc.subject | Drug dose regimen | en |
dc.subject | Drug fatality | en |
dc.subject | Drug hypersensitivity | en |
dc.subject | Drug tolerability | en |
dc.subject | Fever | en |
dc.subject | Gastrointestinal toxicity | en |
dc.subject | Granulocyte colony stimulating factor | en |
dc.subject | Heart ventricle arrhythmia | en |
dc.subject | Initial treatment | en |
dc.subject | Liver toxicity | en |
dc.subject | Minimal residual disease | en |
dc.subject | Ovary tumor | en |
dc.subject | Pain | en |
dc.subject | Patient compliance | en |
dc.subject | Phase 3 clinical trial | en |
dc.subject | Pneumonia | en |
dc.subject | Promethazine | en |
dc.subject | Prospective study | en |
dc.subject | Randomized controlled trial | en |
dc.subject | Standardization | en |
dc.subject | Statistical significance | en |
dc.subject | Survival | en |
dc.subject | Survival rate | en |
dc.subject | Treatment outcome | en |
dc.title | Paclitaxel plus carboplatin versus paclitaxel plus alternating carboplatin and cisplatin for initial treatment of advanced ovarian cancer: Long-term efficacy results: A Hellenic Cooperative Oncology Group (HeCOG) study | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1093/annonc/mdi223 | |
dc.description.volume | 16 | |
dc.description.issue | 7 | |
dc.description.startingpage | 1116 | |
dc.description.endingpage | 1122 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.contributor.orcid | Aravantinos, Gerasimos [0000-0002-2106-1713] | |
dc.contributor.orcid | Kalofonos, H. P. [0000-0002-3286-778X] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |
dc.gnosis.orcid | 0000-0002-2106-1713 | |
dc.gnosis.orcid | 0000-0002-3286-778X | |