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dc.contributor.authorAndreopoulou, E.en
dc.contributor.authorAndreopoulos, D.en
dc.contributor.authorAdamidis, K.en
dc.contributor.authorFountzila-Kalogera, A.en
dc.contributor.authorFountzilas, Georgeen
dc.contributor.authorDimopoulos, M. A.en
dc.contributor.authorAravantinos, Gerasimosen
dc.contributor.authorZamboglou, N.en
dc.contributor.authorBaltas, D.en
dc.contributor.authorPavlidis, Nicholasen
dc.creatorAndreopoulou, E.en
dc.creatorAndreopoulos, D.en
dc.creatorAdamidis, K.en
dc.creatorFountzila-Kalogera, A.en
dc.creatorFountzilas, Georgeen
dc.creatorDimopoulos, M. A.en
dc.creatorAravantinos, Gerasimosen
dc.creatorZamboglou, N.en
dc.creatorBaltas, D.en
dc.creatorPavlidis, Nicholasen
dc.date.accessioned2018-06-22T09:52:27Z
dc.date.available2018-06-22T09:52:27Z
dc.date.issued2002
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41358
dc.description.abstractBackground: The usefulness of tumor volumetry in ovarian epithelial cancer has never been intensively investigated. The aim of the present study was to determine the value of quantitative analysis of tumor volume as a predictive method for response to treatment and as a prognostic method for disease outcome. Materials and Methods: Seventy-five women with advanced ovarian cancer who presented with measurable disease on CT scan prior to chemotherapy were retrospectively studied. The patients were treated with platinum-based chemotherapy. The median follow-up was 113.36 weeks. An independent radiologist identified and delineated tumor contours in each slice of sequential CT scans before and after therapy. Volumetry was measured with a three-dimensional approach by utilizing a digitizer and a specific algorithm on a software computed program. Results: Data were analyzed according to initial and to residual tumor volumes. Patients with low initial volume of 165 CM3) initial tumor volume had a shorter time to progression (p<0.01). Patients without or with low residual volume of <35 cm3 were found to have a longer time to progression (p<0.05) and longer survival (p<0.01 and p<0.05). In addition, serum CA 125 levels followed precisely tumor volumetry for both initial and residual disease. Conclusion: Tumor volumetry in advanced ovarian cancer was found to have predictive value for response to platinum-based chemotherapy. Initial tumor volume has prognostic significance only for the time to progression, whereas residual tumor volume has for both time to progression and survival.en
dc.language.isoengen
dc.sourceAnticancer Researchen
dc.subjectArticleen
dc.subjectCisplatinen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectFemaleen
dc.subjectMajor clinical studyen
dc.subjectMiddle ageden
dc.subjectAdvanced canceren
dc.subjectAlgorithmen
dc.subjectCa-125 antigenen
dc.subjectCancer combination chemotherapyen
dc.subjectCancer growthen
dc.subjectCancer survivalen
dc.subjectCarboplatinen
dc.subjectChemotherapyen
dc.subjectComputer assisted tomographyen
dc.subjectComputer programen
dc.subjectDisease progressionen
dc.subjectDrug responseen
dc.subjectFollow upen
dc.subjectNeoplasmen
dc.subjectNeoplasm stagingen
dc.subjectOvarian canceren
dc.subjectOvarian neoplasmsen
dc.subjectOvary canceren
dc.subjectPaclitaxelen
dc.subjectPlatinum derivativeen
dc.subjectPredictionen
dc.subjectPredictive value of testsen
dc.subjectPriority journalen
dc.subjectPrognosisen
dc.subjectPrognostic and predictive factoren
dc.subjectQuantitative analysisen
dc.subjectQuantitative diagnosisen
dc.subjectResidualen
dc.subjectRetrospective studiesen
dc.subjectRetrospective studyen
dc.subjectTumor volumeen
dc.subjectVolumetryen
dc.titleTumor volumetry as predictive and prognostic factor in the management of ovarian canceren
dc.typeinfo:eu-repo/semantics/article
dc.description.volume22
dc.description.issue3
dc.description.startingpage1903
dc.description.endingpage1908
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidAravantinos, Gerasimos [0000-0002-2106-1713]
dc.gnosis.orcid0000-0002-2195-9961
dc.gnosis.orcid0000-0002-2106-1713


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