Prognostic factors in patients with colorectal cancer receiving adjuvant chemotherapy or chemoradiotherapy: A pooled analysis of two randomized studies
dc.contributor.author | Bamias, A. T. | en |
dc.contributor.author | Basdanis, G. | en |
dc.contributor.author | Xanthakis, I. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Fountzilas, George | en |
dc.creator | Bamias, A. T. | en |
dc.creator | Basdanis, G. | en |
dc.creator | Xanthakis, I. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Fountzilas, George | en |
dc.date.accessioned | 2018-06-22T09:52:31Z | |
dc.date.available | 2018-06-22T09:52:31Z | |
dc.date.issued | 2005 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41398 | |
dc.description.abstract | Background. Although the TNM system is useful in predicting survival in resected colorectal cancer, heterogeneity within the same stages regarding prognosis exists. We are presenting a pooled analysis of prognostic factors from two randomized studies of adjuvant treatment conducted by the Hellenic Cooperative Oncology Group. Patients and Methods. Patients with stage II or III colon (n = 279) or rectal (n = 220) cancer were included in this analysis. Following surgery, patients received: 5-fluorouracil/leucovorin (5-FU/LV) (n = 135), 5-FU/LV and interferon Alfa-2a (IFNA-2a) (n = 138), 5-FU/LV and pelvic chemoradiotherapy (n = 106), and pelvic chemoradiotherapy alone (n = 108). Results. Median follow up was 92 mo. The number of involved lymph nodes (LNs), tumor differentiation, and the presence of regional implants were independent prognostic factors for both OS and TTP, while nerve invasion was only significant for TTP. Patients were stratified into three prognostic groups (low-risk: no LNs and grade 1/2; high-risk: > 3 LNs and grade 3/4; intermediate-risk: remaining patients) with distinct differences in 5-yr survival (84.7% vs 57.6% vs 32.4%) and 5-yr TTP (81.2% vs 54.5% vs 28.6%). Conclusion. The combination of clinicopathological prognostic factors can be more informative than the traditional TNM staging system. Such stratification may be necessary in randomized trials and could be useful in deciding the most appropriate adjuvant treatment strategies. © Copyright 2005 by Humana Press Inc. All rights of any nature whatsoever reserved. | en |
dc.language.iso | eng | en |
dc.source | International Journal of Gastrointestinal Cancer | en |
dc.subject | Article | en |
dc.subject | Antineoplastic agents | en |
dc.subject | Fluorouracil | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Controlled study | en |
dc.subject | Female | en |
dc.subject | Major clinical study | en |
dc.subject | Middle aged | en |
dc.subject | Cancer combination chemotherapy | en |
dc.subject | Cancer survival | en |
dc.subject | Chemotherapy | en |
dc.subject | Follow up | en |
dc.subject | Prediction | en |
dc.subject | Priority journal | en |
dc.subject | Prognosis | en |
dc.subject | Retrospective studies | en |
dc.subject | Clinical trial | en |
dc.subject | Controlled clinical trial | en |
dc.subject | Survival analysis | en |
dc.subject | Randomized controlled trial | en |
dc.subject | Survival rate | en |
dc.subject | Cancer surgery | en |
dc.subject | Cancer radiotherapy | en |
dc.subject | Folinic acid | en |
dc.subject | Male | en |
dc.subject | Adjuvant | en |
dc.subject | Interferon alfa-2a | en |
dc.subject | Risk assessment | en |
dc.subject | Cancer risk | en |
dc.subject | Follow-up studies | en |
dc.subject | Lymphatic metastasis | en |
dc.subject | Cancer grading | en |
dc.subject | Histopathology | en |
dc.subject | 5-fu | en |
dc.subject | Adjuvant therapy | en |
dc.subject | Alpha2a interferon | en |
dc.subject | Cancer adjuvant therapy | en |
dc.subject | Cancer center | en |
dc.subject | Colorectal cancer | en |
dc.subject | Colorectal carcinoma | en |
dc.subject | Colorectal neoplasms | en |
dc.subject | Leucovorin | en |
dc.subject | Lymph node metastasis | en |
dc.subject | Prognostic factors | en |
dc.subject | Radiotherapy | en |
dc.subject | Randomized controlled trials | en |
dc.subject | Tissue section | en |
dc.title | Prognostic factors in patients with colorectal cancer receiving adjuvant chemotherapy or chemoradiotherapy: A pooled analysis of two randomized studies | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1385/IJGC:36:1:029 | |
dc.description.volume | 36 | |
dc.description.issue | 1 | |
dc.description.startingpage | 29 | |
dc.description.endingpage | 38 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.gnosis.orcid | 0000-0002-2195-9961 |
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