dc.contributor.author | Berger, Steffen | en |
dc.contributor.author | Rufener, J. | en |
dc.contributor.author | Klimek, Peter Michael | en |
dc.contributor.author | Zachariou, Zacharias | en |
dc.contributor.author | Boillat, Colette | en |
dc.creator | Berger, Steffen | en |
dc.creator | Rufener, J. | en |
dc.creator | Klimek, Peter Michael | en |
dc.creator | Zachariou, Zacharias | en |
dc.creator | Boillat, Colette | en |
dc.date.accessioned | 2018-06-22T09:52:33Z | |
dc.date.available | 2018-06-22T09:52:33Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41414 | |
dc.description.abstract | Background: After resection of long-segment Hirschsprung's disease, severe perianal dermatitis (SPAD) may occur because of high stool frequency and elevated concentrations of fecal pancreatic proteases. We investigated prospectively the effect of potato-derived protease inhibitors (PPI) on skin conditions in children with postoperative SPAD. Methods: Four children (aged 12 to 24 months) with therapy-resistant SPAD after transanal endorectal pull-through for long-segment Hirschsprung's disease received topical PPI (1% in 20% zinc ointment) with each diaper-change. Parents noted down a subjective dermatitis score daily. Photo documentation and outpatient visits were made to assess the treatment results. Results: No adverse effects were observed after treatment with PPI. A remarkable improvement of the dermatitis in 3 of the 4 patients as well as improvements in pain and sleep disorders were observed during the PPI-treatment course. Conclusion: The results of the study suggest that PPI may reduce otherwise intractable protease-induced skin irritation in infants. © Children's Hospital, Zhejiang University School of Medicine, China and Springer-Verlag Berlin Heidelberg 2012. | en |
dc.language.iso | eng | en |
dc.source | World Journal of Pediatrics | en |
dc.subject | Hirschsprung's disease | de |
dc.subject | Perianal dermatitis | en |
dc.subject | Protease inhibitor | en |
dc.subject | Transanal endorectal pull-through | en |
dc.title | Effects of potato-derived protease inhibitors on perianal dermatitis after colon resection for long-segment Hirschsprung's disease | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1007/s12519-012-0356-2 | |
dc.description.volume | 8 | |
dc.description.issue | 2 | |
dc.description.startingpage | 173 | |
dc.description.endingpage | 176 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Zachariou, Zacharias [0000-0001-8305-8037] | |
dc.gnosis.orcid | 0000-0001-8305-8037 | |