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dc.contributor.authorBousquet, Jeanen
dc.contributor.authorJorgensen, Christianen
dc.contributor.authorDauzat, Michelen
dc.contributor.authorCesario, A.en
dc.contributor.authorCamuzat, Thierryen
dc.contributor.authorBourret, Rodolpheen
dc.contributor.authorBest, N.en
dc.contributor.authorAnto, Josep M.en
dc.contributor.authorAbecassis, Fredeticen
dc.contributor.authorAubas, Pierreen
dc.contributor.authorAvignon, Antoineen
dc.contributor.authorBadin, Melanieen
dc.contributor.authorBedbrook, Annaen
dc.contributor.authorBlain, Huberten
dc.contributor.authorBourdin, Arnauden
dc.contributor.authorBringer, Jacquesen
dc.contributor.authorCamu, Williamen
dc.contributor.authorCayla, Guilhaumeen
dc.contributor.authorCosta, David J.en
dc.contributor.authorCourtet, Philippeen
dc.contributor.authorCristol, J.-P.en
dc.contributor.authorDemoly, Pascalen
dc.contributor.authorCoussaye, J.-E. de laen
dc.contributor.authorFesler, Pierreen
dc.contributor.authorGouzi, Faresen
dc.contributor.authorGris, Jean-Christopheen
dc.contributor.authorGuillot, Bernarden
dc.contributor.authorHayot, M.en
dc.contributor.authorJeandel, Claudeen
dc.contributor.authorJonquet, Olivieren
dc.contributor.authorJournot, Laurenten
dc.contributor.authorLehmann, Sylvainen
dc.contributor.authorMathieu, Gwenaelleen
dc.contributor.authorMorel, Jacquesen
dc.contributor.authorNinot, G.en
dc.contributor.authorPélissier, J.en
dc.contributor.authorPicot, M.-C.en
dc.contributor.authorRadier-Pontal, F.en
dc.contributor.authorRobine, J. M.en
dc.contributor.authorRodier, M.en
dc.contributor.authorRoubille, F.en
dc.contributor.authorSultan, A.en
dc.contributor.authorWojtusciszyn, A.en
dc.contributor.authorAuffray, Charlesen
dc.contributor.authorBalling, Rudien
dc.contributor.authorBarbara, Cristinaen
dc.contributor.authorCambon-Thomsen, Anneen
dc.contributor.authorChavannes, Niels H.en
dc.contributor.authorChuchalin, Alexander G.en
dc.contributor.authorCrooks, Georgeen
dc.contributor.authorDedeu, Antonien
dc.contributor.authorFabbri, Leonardo M.en
dc.contributor.authorGarcia-Aymerich, Judithen
dc.contributor.authorHajjam, Jawaden
dc.contributor.authorGomes, E. M.en
dc.contributor.authorPalkonen, S.en
dc.contributor.authorPiette, F.en
dc.contributor.authorPison, C.en
dc.contributor.authorPrice, D.en
dc.contributor.authorSamolinski, B.en
dc.contributor.authorSchunemann, H. J.en
dc.contributor.authorSterk, P. J.en
dc.contributor.authorYiallouros, Panayiotis K.en
dc.contributor.authorRoca, J.en
dc.contributor.authorPerre, P. Van deen
dc.contributor.authorMercier, Jacquesen
dc.contributor.otherBousquet, Jeanen
dc.contributor.otherJorgensen, Christianen
dc.contributor.otherDauzat, Michelen
dc.contributor.otherCesario, A.en
dc.contributor.otherCamuzat, Thierryen
dc.contributor.otherBourret, Rodolpheen
dc.contributor.otherBest, N.en
dc.contributor.otherAnto, Josep M.en
dc.contributor.otherAbecassis, Fredeticen
dc.contributor.otherAubas, Pierreen
dc.contributor.otherAvignon, Antoineen
dc.contributor.otherBadin, Melanieen
dc.contributor.otherBedbrook, Annaen
dc.contributor.otherBlain, Huberten
dc.contributor.otherBourdin, Arnauden
dc.contributor.otherBringer, Jacquesen
dc.contributor.otherCamu, Williamen
dc.contributor.otherCayla, Guilhaumeen
dc.contributor.otherCosta, David J.en
dc.contributor.otherCourtet, Philippeen
dc.contributor.otherCristol, J.-P.en
dc.contributor.otherDemoly, Pascalen
dc.contributor.otherCoussaye, J.-E. de laen
dc.contributor.otherFesler, Pierreen
dc.contributor.otherGouzi, Faresen
dc.contributor.otherGris, Jean-Christopheen
dc.contributor.otherGuillot, Bernarden
dc.contributor.otherHayot, M.en
dc.contributor.otherJeandel, Claudeen
dc.contributor.otherJonquet, Olivieren
dc.contributor.otherJournot, Laurenten
dc.contributor.otherLehmann, Sylvainen
dc.contributor.otherMathieu, Gwenaelleen
dc.contributor.otherMorel, Jacquesen
dc.contributor.otherNinot, G.en
dc.contributor.otherPélissier, J.en
dc.contributor.otherPicot, M.-C.en
dc.contributor.otherRadier-Pontal, F.en
dc.contributor.otherRobine, J. M.en
dc.contributor.otherRodier, M.en
dc.contributor.otherRoubille, F.en
dc.contributor.otherSultan, A.en
dc.contributor.otherWojtusciszyn, A.en
dc.contributor.otherAuffray, Charlesen
dc.contributor.otherBalling, Rudien
dc.contributor.otherBarbara, Cristinaen
dc.contributor.otherCambon-Thomsen, Anneen
dc.contributor.otherChavannes, Niels H.en
dc.contributor.otherChuchalin, Alexander G.en
dc.contributor.otherCrooks, Georgeen
dc.contributor.otherDedeu, Antonien
dc.contributor.otherFabbri, Leonardo M.en
dc.contributor.otherGarcia-Aymerich, Judithen
dc.contributor.otherHajjam, Jawaden
dc.contributor.otherGomes, E. M.en
dc.contributor.otherPalkonen, S.en
dc.contributor.otherPiette, F.en
dc.contributor.otherPison, C.en
dc.contributor.otherPrice, D.en
dc.contributor.otherSamolinski, B.en
dc.contributor.otherSchunemann, H. J.en
dc.contributor.otherSterk, P. J.en
dc.contributor.otherRoca, J.en
dc.contributor.otherPerre, P. Van deen
dc.contributor.otherMercier, Jacquesen
dc.creatorBousquet, Jeanen
dc.creatorJorgensen, Christianen
dc.creatorDauzat, Michelen
dc.creatorCesario, A.en
dc.creatorCamuzat, Thierryen
dc.creatorBourret, Rodolpheen
dc.creatorBest, N.en
dc.creatorAnto, Josep M.en
dc.creatorAbecassis, Fredeticen
dc.creatorAubas, Pierreen
dc.creatorAvignon, Antoineen
dc.creatorBadin, Melanieen
dc.creatorBedbrook, Annaen
dc.creatorBlain, Huberten
dc.creatorBourdin, Arnauden
dc.creatorBringer, Jacquesen
dc.creatorCamu, Williamen
dc.creatorCayla, Guilhaumeen
dc.creatorCosta, David J.en
dc.creatorCourtet, Philippeen
dc.creatorCristol, J.-P.en
dc.creatorDemoly, Pascalen
dc.creatorCoussaye, J.-E. de laen
dc.creatorFesler, Pierreen
dc.creatorGouzi, Faresen
dc.creatorGris, Jean-Christopheen
dc.creatorGuillot, Bernarden
dc.creatorHayot, M.en
dc.creatorJeandel, Claudeen
dc.creatorJonquet, Olivieren
dc.creatorJournot, Laurenten
dc.creatorLehmann, Sylvainen
dc.creatorMathieu, Gwenaelleen
dc.creatorMorel, Jacquesen
dc.creatorNinot, G.en
dc.creatorPélissier, J.en
dc.creatorPicot, M.-C.en
dc.creatorRadier-Pontal, F.en
dc.creatorRobine, J. M.en
dc.creatorRodier, M.en
dc.creatorRoubille, F.en
dc.creatorSultan, A.en
dc.creatorWojtusciszyn, A.en
dc.creatorAuffray, Charlesen
dc.creatorBalling, Rudien
dc.creatorBarbara, Cristinaen
dc.creatorCambon-Thomsen, Anneen
dc.creatorChavannes, Niels H.en
dc.creatorChuchalin, Alexander G.en
dc.creatorCrooks, Georgeen
dc.creatorDedeu, Antonien
dc.creatorFabbri, Leonardo M.en
dc.creatorGarcia-Aymerich, Judithen
dc.creatorHajjam, Jawaden
dc.creatorGomes, E. M.en
dc.creatorPalkonen, S.en
dc.creatorPiette, F.en
dc.creatorPison, C.en
dc.creatorPrice, D.en
dc.creatorSamolinski, B.en
dc.creatorSchunemann, H. J.en
dc.creatorSterk, P. J.en
dc.creatorYiallouros, Panayiotis K.en
dc.creatorRoca, J.en
dc.creatorPerre, P. Van deen
dc.creatorMercier, Jacquesen
dc.date.accessioned2018-06-22T09:52:36Z
dc.date.available2018-06-22T09:52:36Z
dc.date.issued2014
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41427
dc.description.abstractChronic diseases are diseases of long duration and slow progression. Major NCDs (cardiovascular diseases, cancer, chronic respiratory diseases, diabetes, rheumatologic diseases and mental health) represent the predominant health problem of the Century. The prevention and control of NCDs are the priority of the World Health Organization 2008 Action Plan, the United Nations 2010 Resolution and the European Union 2010 Council. The novel trend for the management of NCDs is evolving towards integrative, holistic approaches. NCDs are intertwined with ageing. The European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) has prioritised NCDs. To tackle them in their totality in order to reduce their burden and societal impact, it is proposed that NCDs should be considered as a single expression of disease with different risk factors and entities. An innovative integrated health system built around systems medicine and strategic partnerships is proposed to combat NCDs. It includes (i) understanding the social, economic, environmental, genetic determinants, as well as the molecular and cellular mechanisms underlying NCDs; (ii) primary care and practice-based interprofessional collaboration; (iii) carefully phenotyped patients; (iv) development of unbiased and accurate biomarkers for comorbidities, severity and follow up of patients; (v) socio-economic science; (vi) development of guidelines; (vii) training; and (viii) policy decisions. The results could be applicable to all countries and adapted to local needs, economy and health systems. This paper reviews the complexity of NCDs intertwined with ageing. It gives an overview of the problem and proposes two practical examples of systems medicine (MeDALL) applied to allergy and to NCD co-morbidities (MACVIA-LR, Reference Site of the European Innovation Partnership on Active and Healthy Ageing). © 2014 Bentham Science Publishers.en
dc.language.isoengen
dc.sourceCurrent pharmaceutical designen
dc.subjectActive and healthy ageingen
dc.subjectChronic diseaseen
dc.subjectCo-morbiditiesen
dc.subjectHealth systemen
dc.subjectMacvia-lren
dc.subjectMedallen
dc.subjectPatienten
dc.subjectSystems medicineen
dc.titleSystems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policiesen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume20
dc.description.issue38
dc.description.startingpage5928
dc.description.endingpage5944
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidYiallouros, Panayiotis K. [0000-0002-8339-9285]
dc.gnosis.orcid0000-0002-8339-9285


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