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dc.contributor.authorBoussios, Stergiosen
dc.contributor.authorKostadima, Vasilikien
dc.contributor.authorBatistatou, Annaen
dc.contributor.authorToumpoulis, Ioannis K.en
dc.contributor.authorFotopoulos, Georgeen
dc.contributor.authorArgyropoulou, Maria I.en
dc.contributor.authorPavlidis, Nicholasen
dc.creatorBoussios, Stergiosen
dc.creatorKostadima, Vasilikien
dc.creatorBatistatou, Annaen
dc.creatorToumpoulis, Ioannis K.en
dc.creatorFotopoulos, Georgeen
dc.creatorArgyropoulou, Maria I.en
dc.creatorPavlidis, Nicholasen
dc.date.accessioned2018-06-22T09:52:37Z
dc.date.available2018-06-22T09:52:37Z
dc.date.issued2015
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41436
dc.description.abstractMultiple sclerosis (MS) is a chronic autoimmune disease that targets myelinated axons in the central nervous system (CNS). Cancer of unknown primary site (CUP) is a well-recognised clinical disorder, accounting for 3-5% of all malignant epithelial tumors. CUP is clinically characterised as an aggressive disease with early dissemination. Studies of cancer risk in MS patients have shown inconsistent findings. An increased risk of malignancy in patients with MS has been suggested, but recently serious questions have been raised regarding this association. Use of disease-modifying therapies might contribute to an increased cancer risk in selected MS patients. The concurrence of MS and CUP is exceptionally rare. Here we describe the case of a neuroendocrine carcinoma of unknown primary diagnosed in a male patient with a nine-year history of MS. The discussion includes data from all available population-based register studies with estimates of certain malignancies in patients with MS.en
dc.language.isoengen
dc.sourceCase Reports in Oncological Medicineen
dc.titleNeuroendocrine cell carcinoma of unknown primary arising in long standing history of multiple sclerosisen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1155/2015/135976
dc.description.volume2015
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidBoussios, Stergios [0000-0002-2512-6131]
dc.contributor.orcidToumpoulis, Ioannis K. [0000-0002-1874-1785]
dc.contributor.orcidArgyropoulou, Maria I. [0000-0001-7236-3706]
dc.contributor.orcidFotopoulos, George [0000-0001-7393-4080]
dc.gnosis.orcid0000-0002-2195-9961
dc.gnosis.orcid0000-0002-2512-6131
dc.gnosis.orcid0000-0002-1874-1785
dc.gnosis.orcid0000-0001-7236-3706
dc.gnosis.orcid0000-0001-7393-4080


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