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CENP-B specific anti-centromere autoantibodies heralding small-cell lung cancer. A case study and review of the literature

dc.contributor.authorBriassoulis, E. Chen
dc.contributor.authorKamposioras, K.en
dc.contributor.authorTzovaras, V.en
dc.contributor.authorPafitanis, G.en
dc.contributor.authorKostoula, A.en
dc.contributor.authorMavridis, A. K.en
dc.contributor.authorPavlidis, Nicholasen
dc.creatorBriassoulis, E. Chen
dc.creatorKamposioras, K.en
dc.creatorTzovaras, V.en
dc.creatorPafitanis, G.en
dc.creatorKostoula, A.en
dc.creatorMavridis, A. K.en
dc.creatorPavlidis, Nicholasen
dc.date.accessioned2018-06-22T09:52:37Z
dc.date.available2018-06-22T09:52:37Z
dc.date.issued2008
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41438
dc.description.abstractWe report on a small-cell lung cancer case that was heralded by the presence of CENP-B specific anti-centromere autoantibodies (ACA) detected well before the diagnosis of cancer. The patient received chemotherapy plus radiotherapy, which resulted in complete remission of the tumor. Serum ACA levels were zeroed at the time of radiological documentation of tumor response and remained undetected at serial follow-up assessments until they rose again along with documentation of tumor recurrence which occurred 12 months later. We review in brief published research and discuss anti-centromere autoantibodies as potential biomarkers in small-cell lung cancer, a highly proliferative tumor which lacks sensitive serum markers. © 2007 Elsevier Ireland Ltd. All rights reserved.en
dc.language.isoengen
dc.sourceLung Canceren
dc.subjectArticleen
dc.subjectCancer chemotherapyen
dc.subjectCisplatinen
dc.subjectEtoposideen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectFemaleen
dc.subjectMiddle ageden
dc.subjectComputer assisted tomographyen
dc.subjectPriority journalen
dc.subjectAntineoplastic combined chemotherapy protocolsen
dc.subjectLung neoplasmsen
dc.subjectLung small cell canceren
dc.subjectCancer diagnosisen
dc.subjectCancer radiotherapyen
dc.subjectCarcinomaen
dc.subjectAntibodiesen
dc.subjectCase reporten
dc.subjectRadiotherapyen
dc.subjectThorax radiographyen
dc.subjectTreatment responseen
dc.subjectAntibody detectionen
dc.subjectAntinuclearen
dc.subjectAntinuclear antibodyen
dc.subjectAutoantibodiesen
dc.subjectAutoantibodyen
dc.subjectAutoantigensen
dc.subjectBlood analysisen
dc.subjectCancer regressionen
dc.subjectCentromere protein ben
dc.subjectCentromere-protein-ben
dc.subjectChemical analysisen
dc.subjectClinical examinationen
dc.subjectCombined modality therapyen
dc.subjectFiberoptic bronchoscopyen
dc.subjectFluorescent antibody techniqueen
dc.subjectImmunoblottingen
dc.subjectImmunofluorescenceen
dc.subjectSmall cellen
dc.subjectSmall-cell lungen
dc.subjectSmokingen
dc.subjectSuperior cava vein syndromeen
dc.subjectSuperior vena cava syndromeen
dc.subjectTumor markeren
dc.subjectTumor recurrenceen
dc.subjectTumor-markersen
dc.titleCENP-B specific anti-centromere autoantibodies heralding small-cell lung cancer. A case study and review of the literatureen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.lungcan.2007.09.014
dc.description.volume60
dc.description.issue2
dc.description.startingpage302
dc.description.endingpage306
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.gnosis.orcid0000-0002-2195-9961


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