dc.contributor.author | Cerny, T. | en |
dc.contributor.author | Kaplan, S. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Schöffski, P. | en |
dc.contributor.author | Epelbaum, R. | en |
dc.contributor.author | Meerbeek, J. van | en |
dc.contributor.author | Wanders, J. | en |
dc.contributor.author | Franklin, H. R. | en |
dc.contributor.author | Kaye, Stanley B. | en |
dc.creator | Cerny, T. | en |
dc.creator | Kaplan, S. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Schöffski, P. | en |
dc.creator | Epelbaum, R. | en |
dc.creator | Meerbeek, J. van | en |
dc.creator | Wanders, J. | en |
dc.creator | Franklin, H. R. | en |
dc.creator | Kaye, Stanley B. | en |
dc.date.accessioned | 2018-06-22T09:52:48Z | |
dc.date.available | 2018-06-22T09:52:48Z | |
dc.date.issued | 1994 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41515 | |
dc.description.abstract | In a multicentre trial of the EORTC ECTG we have treated 43 non-pretreated patients with advanced non-small-cell lung cancer (NSCLC) with the new semisynthetic taxoid docetaxel (Taxotere). Six patients were ineligible; of the 37 eligible patients, ten had prior radiotherapy and 18 prior surgery. They received 100 mg m-2 in 1 h i.v. every 3 weeks, usually in an outpatient setting. Prophylactic steroids, antihistaminics or antiemetics were not routinely given. Two patients were not evaluable because they withdrew from the study because of a hypersensitivity reaction after the second cycle. The main toxicity was neutropenia (80% of cycles), although infections were rare (4%). One patient died from sepsis during neutropenia. Hypersensitivity reactions necessitating interruption of docetaxel (Taxotere) infusions were found in only 10% of cycles. The overall response rate was 23% with one complete response, and seven partial responses. Stable disease was found in 16 patients. The median duration of response was 36 weeks, and the median survival of all patients was 11 months. Docetaxel (Taxotere) is among the most active drugs for treatment of NSCLC. © Macmillan Press Ltd., 1994. | en |
dc.language.iso | eng | en |
dc.source | British journal of cancer | en |
dc.subject | Article | en |
dc.subject | Antineoplastic agent | en |
dc.subject | Antineoplastic agents | en |
dc.subject | Human | en |
dc.subject | Tamoxifen | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Female | en |
dc.subject | Cancer survival | en |
dc.subject | Paclitaxel | en |
dc.subject | Priority journal | en |
dc.subject | Alopecia | en |
dc.subject | Anemia | en |
dc.subject | Antineoplastic combined chemotherapy protocols | en |
dc.subject | Clinical article | en |
dc.subject | Clinical trial | en |
dc.subject | Diarrhea | en |
dc.subject | Fatigue | en |
dc.subject | Infection | en |
dc.subject | Leukopenia | en |
dc.subject | Multicenter study | en |
dc.subject | Neurotoxicity | en |
dc.subject | Neutropenia | en |
dc.subject | Phase 2 clinical trial | en |
dc.subject | Phytogenic | en |
dc.subject | Thrombocytopenia | en |
dc.subject | Dexamethasone | en |
dc.subject | Fever | en |
dc.subject | Pain | en |
dc.subject | Docetaxel | en |
dc.subject | Lung neoplasms | en |
dc.subject | Lung non small cell cancer | en |
dc.subject | Antibiotic agent | en |
dc.subject | Carcinoma | en |
dc.subject | Male | en |
dc.subject | Intravenous drug administration | en |
dc.subject | Sepsis | en |
dc.subject | Nausea | en |
dc.subject | Pleura effusion | en |
dc.subject | Lung tumor | en |
dc.subject | Corticosteroid | en |
dc.subject | Antihistaminic agent | en |
dc.subject | Oral drug administration | en |
dc.subject | Drug derivative | en |
dc.subject | Middle age | en |
dc.subject | Skin toxicity | en |
dc.subject | Edema | en |
dc.subject | Asthenia | en |
dc.subject | Death | en |
dc.subject | Dexchlorpheniramine | en |
dc.subject | Hypersensitivity reaction | en |
dc.subject | Non-small-cell lung | en |
dc.subject | Onycholysis | en |
dc.subject | Outpatient | en |
dc.title | Docetaxel (Taxotere™) is active in non-small-cell lung cancer: A phase II trial of the EORTC early clinical trials group (ECTG) | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1038/bjc.1994.311 | |
dc.description.volume | 70 | |
dc.description.issue | 2 | |
dc.description.startingpage | 384 | |
dc.description.endingpage | 387 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |