dc.contributor.author | Delladetsima, I. | en |
dc.contributor.author | Psichogiou, M. | en |
dc.contributor.author | Alexandrou, P. | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Revenas, K. | en |
dc.contributor.author | Hatzakis, A. | en |
dc.contributor.author | Boletis, J. | en |
dc.creator | Delladetsima, I. | en |
dc.creator | Psichogiou, M. | en |
dc.creator | Alexandrou, P. | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Revenas, K. | en |
dc.creator | Hatzakis, A. | en |
dc.creator | Boletis, J. | en |
dc.date.accessioned | 2018-06-22T09:52:49Z | |
dc.date.available | 2018-06-22T09:52:49Z | |
dc.date.issued | 2008 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41522 | |
dc.description.abstract | Hepatocellular injury in renal transplant recipients with hepatitis C virus (HCV) infection remains unclear. The suppressed immune response, in combination with increased viremia levels, provides a unique setting for the study of a potential HCV-induced apoptotic process. Liver biopsy specimens from 59 HCV-infected renal transplant recipients were examined histologically. DNA fragmentation was detected by the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-nick end labeling assay, and the CD8 T-cell count was assessed immunohistochemically.A low apoptotic index (0-2.5) was observed in 31 cases, a moderate index (2.6-5) in 16, and a high index (>5) in 12. Apoptotic cell death correlated significantly with viremia because it was demonstrated by higher HCV-RNA levels in cases with a high number of apoptotic cells (odds ratio, 2.96; 95% confidence interval, 1.0-8.5; P = .04). No correlation was found between the apoptotic index and hepatitis necroinflammatory activity, CD8 cell count, fibrosis stage, immunosuppressive therapy, or genotype. In HCV-infected renal transplant recipients, apoptotic cell death seems to be associated with high viral load, thus providing indications of viral interference in the pathogenetic process. © American Society for Clinical Pathology. | en |
dc.language.iso | eng | en |
dc.source | American Journal of Clinical Pathology | en |
dc.subject | Article | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Female | en |
dc.subject | Priority journal | en |
dc.subject | Human tissue | en |
dc.subject | Confidence interval | en |
dc.subject | Male | en |
dc.subject | Genotype | en |
dc.subject | Pathogenesis | en |
dc.subject | Risk assessment | en |
dc.subject | Correlation analysis | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Blood | en |
dc.subject | Hepatitis c | en |
dc.subject | Pathology | en |
dc.subject | Apoptosis | en |
dc.subject | Immune response | en |
dc.subject | Immunology | en |
dc.subject | Liver injury | en |
dc.subject | Rna | en |
dc.subject | Cd8-positive t-lymphocytes | en |
dc.subject | Cd8+ t lymphocyte | en |
dc.subject | Cell death | en |
dc.subject | Dna fragmentation | en |
dc.subject | Graft recipient | en |
dc.subject | Hepacivirus | en |
dc.subject | Hepatitis c virus | en |
dc.subject | Histology | en |
dc.subject | Immunosuppressive treatment | en |
dc.subject | In situ nick-end labeling | en |
dc.subject | Kidney transplantation | en |
dc.subject | Liver biopsy | en |
dc.subject | Liver cell | en |
dc.subject | Liver fibrosis | en |
dc.subject | Lymphocyte count | en |
dc.subject | Nick end labeling | en |
dc.subject | Physiology | en |
dc.subject | Renal transplantation | en |
dc.subject | Univariate analysis | en |
dc.subject | Viral | en |
dc.subject | Viremia | en |
dc.subject | Virus load | en |
dc.subject | Virus rna | en |
dc.title | Apoptosis and hepatitis C virus infection in renal transplant recipients | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1309/U90671UBGT1GLKLL | |
dc.description.volume | 129 | |
dc.description.issue | 5 | |
dc.description.startingpage | 744 | |
dc.description.endingpage | 748 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Psichogiou, M. [0000-0002-3000-8447] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0002-3000-8447 | |