Show simple item record

dc.contributor.authorElisaf, Moses S.en
dc.contributor.authorBairaktari, Eleni Then
dc.contributor.authorNikolaides, C.en
dc.contributor.authorFountzilas, Georgeen
dc.contributor.authorTzallas, C. S.en
dc.contributor.authorTsolas, O.en
dc.contributor.authorSiamopoulos, K. C.en
dc.contributor.authorPavlidis, Nicholasen
dc.creatorElisaf, Moses S.en
dc.creatorBairaktari, Eleni Then
dc.creatorNikolaides, C.en
dc.creatorFountzilas, Georgeen
dc.creatorTzallas, C. S.en
dc.creatorTsolas, O.en
dc.creatorSiamopoulos, K. C.en
dc.creatorPavlidis, Nicholasen
dc.date.accessioned2018-06-22T09:52:56Z
dc.date.available2018-06-22T09:52:56Z
dc.date.issued1998
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41572
dc.description.abstractBackground and Aim: As a continuation of our investigational program we carried out the present study to evaluate and compare the impact of LH-RH analogues and tamoxifen on serum lipid parameters in premenopausal women with breast cancer. Methods and Results: The study group consisted of 17 fully ambulatory women aged 36-48 years with histologically proven breast cancer, randomly selected to receive an LH-RH analogue. Additionally, a group of 17 premenopausal women matched for age and body mass index chosen from a pool of women treated with tamoxifen, acted as control. A complete lipid profile was determined before treatment and after 1, 3, 6 and 9 months. A decrease in serum total cholesterol, LDL cholesterol, Apo B, and Lp(a) levels was observed in women treated with tamoxifen. On the contrary, no changes in measured lipid parameters were found in women treated with luteinizing hormone-releasing hormone (LH-RH) analogue. Patients treated with tamoxifen exhibited lower total cholesterol, LDL cholesterol, and Apo B levels, as well as lower levels of the atherogenic risk ratio total cholesterol:HDL cholesterol than patients treated with LH-RH analogue throughout the study. These changes depended upon both treatment and time as well as their interaction. Conclusions: We conclude that while tamoxifen has a benefidal effect on serum lipid profile, LH-RH analogues have rather a neutral effect, possibly as a result of the contrasting effects of estrogens and both progestins and androgens on lipid metabolism. ©1998, Medikal Press.en
dc.language.isoengen
dc.sourceNutrition, Metabolism and Cardiovascular Diseasesen
dc.subjectLipid parametersen
dc.subjectTamoxifenen
dc.subjectLh-rh analoguesen
dc.titleDo LH-RH analogues induce effects similar to tamoxifen on serum lipid parameters in premenopausal women with breast cancer? A prospective studyen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume8
dc.description.issue2
dc.description.startingpage101
dc.description.endingpage105
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidElisaf, Moses S. [0000-0003-0505-078X]
dc.gnosis.orcid0000-0002-2195-9961
dc.gnosis.orcid0000-0003-0505-078X


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record