Effect of letrozole on the lipid profile in postmenopausal women with breast cancer
AuthorElisaf, Moses S.
Bairaktari, Eleni Th
Tzallas, C. S.
SourceEuropean journal of cancer
Google Scholar check
MetadataShow full item record
Hormonal therapy plays a central role in the overall treatment of breast cancer. Aromatase inhibitors can inhibit the aromatase enzyme system resulting in a reduction of oestrogens. Letrozole is a non-steroidal aromatase inhibitor that effectively blocks aromatase activity without interfering with adrenal steroid biosynthesis. The drug can significantly reduce the levels of plasma oestrogens, which remain suppressed throughout the treatment. Data are scarce concerning the influence of these drugs on serum lipid levels. In the present study, we evaluated the effects of letrozole on the serum lipid profile in postmenopausal women with breast cancer. A total of 20 patients with breast cancer were treated with letrozole, 2.5 mg once daily. After an overnight fast, serum lipid parameters (total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides, apolipoproteins A1, B and E and lipoprotein (a)) were measured before treatment and at 8 and 16 weeks afterwards. A significant increase in total cholesterol (P = 0.05), LDL cholesterol (P < 0.01) and apolipoprotein B levels (P = 0.05) in the serum, as well as in the atherogenic risk ratios total cholesterol/HDL cholesterol (P < 0.005) and LDL cholesterol/HDL cholesterol (P < 0.005) was noticed after letrozole treatment. We conclude that letrozole administration in postmenopausal women with breast cancer has an unfavourable effect on the serum lipid profile. © 2001 Elsevier Science Ltd. All rights reserved.
Showing items related by title, author, creator and subject.
Liberopoulos, E. N.; Karabina, S. A.; Tselepis, A.; Bairaktari, Eleni Th; Nikolaides, C.; Pavlidis, Nicholas; Elisaf, Moses S. (2002)Background: Tamoxifen has favorable effects on the serum lipid profile. It has been suggested that the apolipoprotein (Apo) E phenotype can influence serum lipid parameters; the ApoE allele 4 (ApoE4) is associated with ...
The effect of tamoxifen therapy on serum apolipoprotein A-I level is modified by the apolipoprotein E phenotype Liberopoulos, E. N.; Pavlidis, Nicholas; Elisaf, Moses S. (2001)
Filippatos, T. D.; Liberopoulos, E. N.; Pavlidis, Nicholas; Elisaf, Moses S.; Mikhailidis, Dimitri P. (2009)Patients with malignant disease may need hormonal therapy as primary or adjuvant treatment or for palliation. Oestrogens usually decrease serum levels of total cholesterol (TC) and low density lipoprotein cholesterol ...