Primary extranodal non Hodgkin's lymphoma of the head and neck in adults: A clinicopathological comparison between tonsillar and non tonsillar lymphomas
dc.contributor.author | Economopoulos, T. | en |
dc.contributor.author | Fountzilas, George | en |
dc.contributor.author | Kostourou, A. | en |
dc.contributor.author | Daniilidis, J. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Andreopoulou, E. | en |
dc.contributor.author | Nicolaou, A. | en |
dc.contributor.author | Papageorgiou, E. | en |
dc.contributor.author | Mellou, S. | en |
dc.contributor.author | Dervenoulas, John | en |
dc.contributor.author | Stathakis, N. | en |
dc.creator | Economopoulos, T. | en |
dc.creator | Fountzilas, George | en |
dc.creator | Kostourou, A. | en |
dc.creator | Daniilidis, J. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Andreopoulou, E. | en |
dc.creator | Nicolaou, A. | en |
dc.creator | Papageorgiou, E. | en |
dc.creator | Mellou, S. | en |
dc.creator | Dervenoulas, John | en |
dc.creator | Stathakis, N. | en |
dc.date.accessioned | 2018-06-22T09:52:57Z | |
dc.date.available | 2018-06-22T09:52:57Z | |
dc.date.issued | 1998 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41582 | |
dc.description.abstract | Primary extranodal NHL of the head and neck (HN-NHL) accounts for 10-20% of all cases of NHL. Despite their frequency, the natural history and biological behaviour of these lymphomas is poorly understood. In this study we analysed the data 116 cases of HN-NHL. There were 65 males and 51 females with a median age of 56 years. The distribution among different anatomical sites was: tonsils 56 cases (48.3%), nasopharynx 15 (12.9%), mandible/gingiva 9 (7.8%), hard palate 7 (6%), parotis 6 (5.2%), thyroid 5 (4.3%), ocular adnexa 4 (3.5%), paranasal sinuses 2 (1.7%). The patients were treated with radiotherapy alone (14 cases), combined chemotherapy (52 cases) and combined modality (50 cases). According to the WF historical classification 73 cases (62.9%) had intermediate, 32 (27.6%) high and 11 (9.5%) low grade. Patients were separated in two groups: Tonsillar NHL (56 cases) and NHL of all other sites (non-tonsillar group - 60 cases). A comparison between the two groups showed that there was no statistically significant difference with respect to age, sex, and histological subtypes. Also treatment reponse was similar (82.1% for the tonsillar vs 83.3% for the non-tonsillar). The two groups differed in stage distribution, survival and pattern of relapse. Stage I was more frequent in the non-tonsillar NHL (60%) in contrast to tonsillar NHL where stage II was more prominent (51.8%). Median survival was 86 months for the tonsillar while it has not been reached yet for the non-tonsillar group had better survival compared to stages I and II of the tonsillar patients. Finally GI tract was a common site of relapse in the tonsillar group while a considerable number in CNS relapses were observed in the non-tonsillar group. We concluded that HN-NHL constitutes a heterogeneous group of patients. Tonsillar lymphomas represent a distinct group with some special clinicopathological findings. | en |
dc.language.iso | eng | en |
dc.source | Anticancer Research | en |
dc.subject | Greece | en |
dc.subject | Age | en |
dc.subject | Article | en |
dc.subject | Gender | en |
dc.subject | Antineoplastic agent | en |
dc.subject | Cancer chemotherapy | en |
dc.subject | Cyclophosphamide | en |
dc.subject | Doxorubicin | en |
dc.subject | Human | en |
dc.subject | Prednisone | en |
dc.subject | Vincristine | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Female | en |
dc.subject | Major clinical study | en |
dc.subject | Middle aged | en |
dc.subject | Cancer survival | en |
dc.subject | Neoplasm staging | en |
dc.subject | Priority journal | en |
dc.subject | Recurrence | en |
dc.subject | Antineoplastic combined chemotherapy protocols | en |
dc.subject | Disease-free survival | en |
dc.subject | Human tissue | en |
dc.subject | Time factors | en |
dc.subject | Adolescent | en |
dc.subject | Survival rate | en |
dc.subject | Cancer radiotherapy | en |
dc.subject | Mitoxantrone | en |
dc.subject | Nonhodgkin lymphoma | en |
dc.subject | Epirubicin | en |
dc.subject | Male | en |
dc.subject | Lymphoma | en |
dc.subject | Cancer grading | en |
dc.subject | Pathology | en |
dc.subject | Combined modality therapy | en |
dc.subject | Hydrocortisone | en |
dc.subject | Histology | en |
dc.subject | Head and neck cancer | en |
dc.subject | Head and neck neoplasms | en |
dc.subject | Non-hodgkin | en |
dc.subject | Prednisolone | en |
dc.subject | Gingiva disease | en |
dc.subject | Head and neck extranodal lymphoma | en |
dc.subject | Hypopharynx cancer | en |
dc.subject | Larynx cancer | en |
dc.subject | Mandible cancer | en |
dc.subject | Methotrexate | en |
dc.subject | Methylprednisolone | en |
dc.subject | Multivariate analysis | en |
dc.subject | Nasopharynx cancer | en |
dc.subject | Nose cavity cancer | en |
dc.subject | Palate disease | en |
dc.subject | Parotid gland carcinoma | en |
dc.subject | Relapse | en |
dc.subject | Tonsil carcinoma | en |
dc.subject | Tonsillar lymphoma | en |
dc.title | Primary extranodal non Hodgkin's lymphoma of the head and neck in adults: A clinicopathological comparison between tonsillar and non tonsillar lymphomas | en |
dc.type | info:eu-repo/semantics/article | |
dc.description.volume | 18 | |
dc.description.issue | 6 B | en |
dc.description.startingpage | 4655 | |
dc.description.endingpage | 4660 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.contributor.orcid | Dervenoulas, John [0000-0001-8395-507X] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |
dc.gnosis.orcid | 0000-0001-8395-507X |
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