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dc.contributor.authorElisaf, Moses S.en
dc.contributor.authorSiamopoulos, K. C.en
dc.contributor.authorBourantas, C. L.en
dc.contributor.authorPapagalanis, N.en
dc.contributor.authorPavlidis, Nicholasen
dc.creatorElisaf, Moses S.en
dc.creatorSiamopoulos, K. C.en
dc.creatorBourantas, C. L.en
dc.creatorPapagalanis, N.en
dc.creatorPavlidis, Nicholasen
dc.date.accessioned2018-06-22T09:53:00Z
dc.date.available2018-06-22T09:53:00Z
dc.date.issued1992
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41606
dc.description.abstractThe aim of this study was, first, to reconfirm the low serum anion gap (SAG) in multiple myeloma patients and, second, to propose the possible pathophysiologic mechanisms involved. We studied 20 patients with IgG multiple myeloma and 13 healthy subjects as controls. The SAG in multiple myeloma patients was significantly lower (p<0.001) compared with the controls. There was a significant inverse correlation between SAG and serum monoclonal immunoglobulin (r = 0.61, p<0.01). Serum sodium in multiple myeloma patients was lower than in the control population (p<0.001) and was negatively correlated to the amount of serum monoclonal protein (r = -0.44, p = 0.01). Serum albumin was significantly lower in the patients than in the normal controls (p<0.001). No correlation between the SAG and serum albumin was found in the patients' group. In conclusion, SAG is low in IgG multiple myeloma patients. This finding is directly associated with the amount of serum paraprotein which influences the value of serum sodium. Hypoalbuminemia could be an additional factor in the pathogenesis of this electrolyte disturbance.en
dc.language.isoengen
dc.sourceEuropean journal of internal medicineen
dc.subjectArticleen
dc.subjectHumanen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectClinical articleen
dc.subjectMaleen
dc.subjectAnion gapen
dc.subjectHyponatremiaen
dc.subjectMultiple myelomaen
dc.titleSerum anion gap in multiple myeloma patientsen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume3
dc.description.issue3
dc.description.startingpage229
dc.description.endingpage232
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidElisaf, Moses S. [0000-0003-0505-078X]
dc.gnosis.orcid0000-0002-2195-9961
dc.gnosis.orcid0000-0003-0505-078X


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