Show simple item record

dc.contributor.authorPsyrri, A.en
dc.contributor.authorKalogeras, K. T.en
dc.contributor.authorKronenwett, R.en
dc.contributor.authorWirtz, R. M.en
dc.contributor.authorBatistatou, Annaen
dc.contributor.authorBournakis, E.en
dc.contributor.authorTimotheadou, E.en
dc.contributor.authorGogas, H.en
dc.contributor.authorAravantinos, Gerasimosen
dc.contributor.authorChristodoulou, C.en
dc.contributor.authorMakatsoris, T.en
dc.contributor.authorLinardou, H.en
dc.contributor.authorPectasides, Dimitriosen
dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorEconomopoulos, T.en
dc.contributor.authorFountzilas, Georgeen
dc.creatorPsyrri, A.en
dc.creatorKalogeras, K. T.en
dc.creatorKronenwett, R.en
dc.creatorWirtz, R. M.en
dc.creatorBatistatou, Annaen
dc.creatorBournakis, E.en
dc.creatorTimotheadou, E.en
dc.creatorGogas, H.en
dc.creatorAravantinos, Gerasimosen
dc.creatorChristodoulou, C.en
dc.creatorMakatsoris, T.en
dc.creatorLinardou, H.en
dc.creatorPectasides, Dimitriosen
dc.creatorPavlidis, Nicholasen
dc.creatorEconomopoulos, T.en
dc.creatorFountzilas, Georgeen
dc.date.accessioned2018-06-22T09:53:01Z
dc.date.available2018-06-22T09:53:01Z
dc.date.issued2012
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41617
dc.description.abstractBackground: The ubiquitin-proteasome system (UPS) plays a pivotal role in tumorigenesis. Components of the UPS have recently been implicated in breast cancer progression. In the present study, we sought to explore the prognostic and/or predictive significance of UBE2C messenger RNA (mRNA) expression on disease-free survival (DFS) and overall survival (OS) in high-risk operable breast cancer patients. Methods: Five hundred and ninety-five high-risk breast cancer patients were treated in a two-arm trial evaluating postoperative, dose-dense sequential chemotherapy with epirubicin followed by CMF (cyclophosphamide, methotrexate and 5-fluorouracil) with or without paclitaxel (Taxol). RNA was extracted from 313 formalin-fixed primary tumor tissue samples followed by one-step quantitative RT-PCR for assessment of mRNA expression of UBE2C. Results: High UBE2C mRNA expression was associated with poor DFS (Wald's P = 0.003) and OS (Wald's P = 0.005). High tumor grade, as well as high Ki67 protein expression, was more frequent in the high-expression group of UBE2C. Results of the Cox multivariate regression analysis revealed that high UBE2C mRNA expression remained an independent adverse prognostic factor for relapse (P = 0.037) and death (P = 0.05). Conclusions: High UBE2C mRNA expression was found to be of adverse prognostic significance in high-risk breast cancer patients. These findings need to be validated in larger cohorts.en
dc.language.isoengen
dc.sourceAnnals of Oncologyen
dc.subjectArticleen
dc.subjectYoung adulten
dc.subjectCancer chemotherapyen
dc.subjectCyclophosphamideen
dc.subjectFluorouracilen
dc.subjectHumanen
dc.subjectMethotrexateen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBreast neoplasmsen
dc.subjectCancer patienten
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectMajor clinical studyen
dc.subjectMiddle ageden
dc.subjectCancer survivalen
dc.subjectNeoplasm stagingen
dc.subjectPaclitaxelen
dc.subjectPriority journalen
dc.subjectPrognosisen
dc.subjectQuantitative analysisen
dc.subjectRetrospective studiesen
dc.subjectRetrospective studyen
dc.subjectAntineoplastic combined chemotherapy protocolsen
dc.subjectDisease-free survivalen
dc.subjectHuman tissueen
dc.subjectDisease free survivalen
dc.subjectCancer relapseen
dc.subjectOverall survivalen
dc.subjectEpirubicinen
dc.subjectGeneticen
dc.subjectProtein expressionen
dc.subjectHigh risk patienten
dc.subjectUnclassified drugen
dc.subjectBreast canceren
dc.subjectCancer gradingen
dc.subjectTissue sectionen
dc.subjectRandomized controlled trials as topicen
dc.subjectMultiple cycle treatmenten
dc.subjectGene expressionen
dc.subjectKaplan-meier estimateen
dc.subjectRnaen
dc.subjectTranscriptionen
dc.subjectMultivariate analysisen
dc.subjectMessenger rnaen
dc.subjectReverse transcription polymerase chain reactionen
dc.subjectKi 67 antigenen
dc.subjectBreast surgeryen
dc.subjectProportional hazards modelsen
dc.subjectPrognostic valueen
dc.subjectMessengeren
dc.subjectRna analysisen
dc.subjectPredictive valueen
dc.subjectDrug dose sequenceen
dc.subjectMrnaen
dc.subjectProtein ube2cen
dc.subjectQrt-pcren
dc.subjectRna extractionen
dc.subjectTumor burdenen
dc.subjectUbe2cen
dc.subjectUbiquitin conjugating enzymeen
dc.subjectUbiquitin-conjugating enzymesen
dc.titlePrognostic significance of UBE2C mRNA expression in high-risk early breast cancer. A hellenic cooperative oncology group (HECOG) studyen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1093/annonc/mdr527
dc.description.volume23
dc.description.issue6
dc.description.startingpage1422
dc.description.endingpage1427
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record