Human peripheral blood and splenic T lymphocyte reactions versus kidney cortical cells
Kyriakides, George K.
Miller, Jody C.
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These data suggest that a lymphoproliferative response to kidney-specific antigens might have been unmasked or amplified by the enzymatic digestion (collagenase, neuraminidase) used in deriving the KC cell population, a reaction not dependent on Ia antigens (at least as defined by L243 anti-DR antibody) as in the allogeneic response. The MLKC data obtained using infiltrating lymphocytes isolated from ESRD kidneys provokes questions regarding the contribution of T cell-mediated autoimmunity in the progression to chronic renal failure.