dc.contributor.author | Georgoulias, Panagiotis | en |
dc.contributor.author | Wozniak, Greta | en |
dc.contributor.author | Samara, Maria | en |
dc.contributor.author | Chiotoglou, Ioanna | en |
dc.contributor.author | Kontos, Angelos | en |
dc.contributor.author | Tzavara, Chara | en |
dc.contributor.author | Valotassiou, Varvara | en |
dc.contributor.author | Georgitsi, Marianna | en |
dc.contributor.author | Aleporou-Marinou, Vassiliki | en |
dc.contributor.author | Patrinos, George P. | en |
dc.contributor.author | Kollia, Panagoula | en |
dc.creator | Georgoulias, Panagiotis | en |
dc.creator | Wozniak, Greta | en |
dc.creator | Samara, Maria | en |
dc.creator | Chiotoglou, Ioanna | en |
dc.creator | Kontos, Angelos | en |
dc.creator | Tzavara, Chara | en |
dc.creator | Valotassiou, Varvara | en |
dc.creator | Georgitsi, Marianna | en |
dc.creator | Aleporou-Marinou, Vassiliki | en |
dc.creator | Patrinos, George P. | en |
dc.creator | Kollia, Panagoula | en |
dc.date.accessioned | 2018-06-22T09:53:13Z | |
dc.date.available | 2018-06-22T09:53:13Z | |
dc.date.issued | 2009 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41719 | |
dc.description.abstract | Coronary artery disease is associated with multiple genetic and environmental risk factors. In this study, we evaluated the correlation of angiotensin l-converting enzyme (ACE) (I/D) and ApoE gene polymorphisms (E2, E3, E4 and g.-219G/T) with myocardial perfusion. We examined 410 patients using exercise-rest myocardial perfusion single photon emission computed tomography (SPECT), in which the summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS) indexes were calculated. Homozygotes for the ACE D allele had greater mean values of SSS (P0.001) and SDS (P0.001). In addition, E3 homozygotes, E4 heterozygotes and E4 homozygotes had significantly higher values of SSS and SDS compared with E3 heterozygotes (P0.001); E4 homozygotes had significantly higher values of SSS and SDS compared with E3 homozygotes. Furthermore, for the g.-219GT polymorphic site at the promoter region of ApoE gene, the mean values of SSS and SDS were significantly higher for T heterozygotes/homozygotes than for GG homozygotes. Adjusting for all demographic and clinical data using multiple linear regression analysis it was found that ACE D and both ApoE genotypes were independent predictors with a cumulative contribution for the prediction of SSS and SDS. Furthermore, logistic regression analysis revealed that all three genotypes had an independent predictive ability for abnormal SSS (SSS2). These data provide the first evidence of an association and significant cumulative contribution of the aforementioned genotypes in myocardial perfusion with E4 allele having the strongest association followed by ACE D and ApoE g.-219T alleles. © 2009 The Japan Society of Human Genetics All rights reserved. | en |
dc.language.iso | eng | en |
dc.source | Journal of human genetics | en |
dc.subject | Demography | en |
dc.subject | Article | en |
dc.subject | Human | en |
dc.subject | 80 and over | en |
dc.subject | Aged | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Female | en |
dc.subject | Major clinical study | en |
dc.subject | Middle aged | en |
dc.subject | Prediction | en |
dc.subject | Male | en |
dc.subject | Allele | en |
dc.subject | Genetic association | en |
dc.subject | Antihypertensive agent | en |
dc.subject | Genotype | en |
dc.subject | Genetic polymorphism | en |
dc.subject | Promoter region | en |
dc.subject | Hypertension | en |
dc.subject | Apolipoproteins e | en |
dc.subject | Heart muscle perfusion | en |
dc.subject | Single photon emission computer tomography | en |
dc.subject | Angiotensin l-converting enzyme (ace) | en |
dc.subject | Apolipoprotein e2 | en |
dc.subject | Apolipoprotein e3 | en |
dc.subject | Apolipoprotein e4 | en |
dc.subject | Apolipototein e (apoe) | en |
dc.subject | Coronary artery disease | en |
dc.subject | Coronary circulation | en |
dc.subject | Dipeptidyl carboxypeptidase | en |
dc.subject | Emission-computed | en |
dc.subject | Exercise test | en |
dc.subject | Gene frequency | en |
dc.subject | Genetic analysis | en |
dc.subject | Heart | en |
dc.subject | Heart muscle ischemia | en |
dc.subject | Heterozygote | en |
dc.subject | Homozygote | en |
dc.subject | Myocardial perfusion imaging | en |
dc.subject | Myocardial single photon emission computed tomography (spect) | en |
dc.subject | Organophosphorus compounds | en |
dc.subject | Organotechnetium compounds | en |
dc.subject | Peptidyl-dipeptidase a | en |
dc.subject | Polymorphisms | en |
dc.subject | Rest | en |
dc.subject | Scoring system | en |
dc.subject | Single-photon | en |
dc.subject | Tetrofosmin tc 99m | en |
dc.subject | Thallium 201 | en |
dc.subject | Thallium radioisotopes | en |
dc.subject | Tomography | en |
dc.title | Impact of ACE and ApoE polymorphisms on myocardial perfusion: Correlation with myocardial single photon emission computed tomographic imaging | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1038/jhg.2009.83 | |
dc.description.volume | 54 | |
dc.description.issue | 10 | |
dc.description.startingpage | 595 | |
dc.description.endingpage | 602 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Wozniak, Greta [0000-0002-8939-0927] | |
dc.contributor.orcid | Georgoulias, Panagiotis [0000-0002-6493-705X] | |
dc.contributor.orcid | Samara, Maria [0000-0003-0433-6436] | |
dc.contributor.orcid | Kollia, Panagoula [0000-0002-0635-3996] | |
dc.contributor.orcid | Patrinos, George P. [0000-0002-0519-7776] | |
dc.contributor.orcid | Georgitsi, Marianna [0000-0002-0354-0913] | |
dc.gnosis.orcid | 0000-0002-8939-0927 | |
dc.gnosis.orcid | 0000-0002-6493-705X | |
dc.gnosis.orcid | 0000-0003-0433-6436 | |
dc.gnosis.orcid | 0000-0002-0635-3996 | |
dc.gnosis.orcid | 0000-0002-0519-7776 | |
dc.gnosis.orcid | 0000-0002-0354-0913 | |