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dc.contributor.authorSkarlos, Dimosthenis V.en
dc.contributor.authorSamantas, E.en
dc.contributor.authorKosmidis, Paraskevas A.en
dc.contributor.authorFountzilas, Georgeen
dc.contributor.authorAngelidou, M.en
dc.contributor.authorPalamidas, P.en
dc.contributor.authorMylonakis, N.en
dc.contributor.authorProvata, A.en
dc.contributor.authorPapadakis, E.en
dc.contributor.authorKlouvas, G. D.en
dc.contributor.authorTheocharis, D.en
dc.contributor.authorPanoussaki, E.en
dc.contributor.authorBoleti, E.en
dc.contributor.authorSphakianoudis, G.en
dc.contributor.authorPavlidis, Nicholasen
dc.creatorSkarlos, Dimosthenis V.en
dc.creatorSamantas, E.en
dc.creatorKosmidis, Paraskevas A.en
dc.creatorFountzilas, Georgeen
dc.creatorAngelidou, M.en
dc.creatorPalamidas, P.en
dc.creatorMylonakis, N.en
dc.creatorProvata, A.en
dc.creatorPapadakis, E.en
dc.creatorKlouvas, G. D.en
dc.creatorTheocharis, D.en
dc.creatorPanoussaki, E.en
dc.creatorBoleti, E.en
dc.creatorSphakianoudis, G.en
dc.creatorPavlidis, Nicholasen
dc.date.accessioned2018-06-22T09:53:13Z
dc.date.available2018-06-22T09:53:13Z
dc.date.issued1994
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41723
dc.description.abstractPurpose: To compare the efficacy and toxicity of etoposide and cisplatin (EP) with etoposide and carboplatin (EC) in combination with irradiation in small-cell lung cancer (SCLC). Methods: Previously untreated patients (pts) with SCLC and measurable or evaluable disease were randomized to receive either cisplatin 50 mg/m2 on days 1-2 or carboplatin 300 mg/m2 on day 1, both combined with etoposide 300 mg/m2 on days 1-3 every 21 days for 6 treatment cycles. The vast majority of responding limited disease (LD) pts and complete responders (CR) with extensive disease (ED), also received thoracic irradiation (TI) and prophylactic cranial irradiation (PCI) concurrently with the third cycle. Results: Of the 147 patients registered, 143 were eligible; median performance status (PS, WHO) was 1, and tumour stage was LD in 41 pts of each treatment group. The mean delay between cycles was 8 days in the EP group and 9 in the EC group increasing in both arms with the number of treatment courses. The drug dose administered per unit time as a proportion of the protocol dose was 74% and 80% for the two groups respectively. Leukopenia, neutropenic infections, nausea, vomiting, neurotoxicity and hyperergic reactions were more frequent and/or severe in the EP group. The CR rates were 57% and 58% for EP and EC respectively. Median survival for all pts was 12.5 and 11.8 months, respectively. Conclusion: Both treatments proved to be effective, with no differences in response and survival between the two treatment arms. The EC regimen was associated with significantly less toxicity. © 1994 Kluwer Academic Publishers.en
dc.language.isoengen
dc.sourceAnnals of Oncologyen
dc.subjectGreeceen
dc.subjectArticleen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectMajor clinical studyen
dc.subjectMiddle ageden
dc.subjectPriority journalen
dc.subjectAntineoplastic combined chemotherapy protocolsen
dc.subjectCisplatinen
dc.subjectClinical trialen
dc.subjectControlled clinical trialen
dc.subjectLeukopeniaen
dc.subjectNeurotoxicityen
dc.subjectEtoposideen
dc.subjectRandomized controlled trialen
dc.subjectLung neoplasmsen
dc.subjectLung small cell canceren
dc.subjectSurvival rateen
dc.subjectCarcinomaen
dc.subjectMaleen
dc.subjectCarboplatinen
dc.subjectIntravenous drug administrationen
dc.subjectVomitingen
dc.subjectFollow-up studiesen
dc.subjectCombined modality therapyen
dc.subjectSmall cellen
dc.subjectRemission inductionen
dc.subjectCranial irradiationen
dc.subjectSmall-cell lung cancer (sclc)en
dc.titleRandomized comparison of etoposide-cisplatin vs. etoposide-carboplatin and irradiation in small-cell lung cancer: A hellenic co-operative oncology group studyen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume5
dc.description.issue7
dc.description.startingpage601
dc.description.endingpage607
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.gnosis.orcid0000-0002-2195-9961


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